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Composition of reuptake inhibitor of 5-hydroxytryptamine and noradrenaline and cannabidiol and applications of composition

A technology of norepinephrine and reuptake inhibitors, applied to the composition of serotonin and norepinephrine reuptake inhibitors and cannabidiol and its application field

Active Publication Date: 2018-05-29
HANYI BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The higher norepinephrine activity of SNRIs is also involved in many side effects, thus limiting their application
For example, currently available SNRIs have limited application for the treatment of irritable bowel syndrome (IBS) due to the side effect of constipation associated with higher NE activity

Method used

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  • Composition of reuptake inhibitor of 5-hydroxytryptamine and noradrenaline and cannabidiol and applications of composition
  • Composition of reuptake inhibitor of 5-hydroxytryptamine and noradrenaline and cannabidiol and applications of composition
  • Composition of reuptake inhibitor of 5-hydroxytryptamine and noradrenaline and cannabidiol and applications of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1 The formula that the composition of the present invention can realize is enumerated

[0059] Some non-limiting examples of formulations of serotonin and norepinephrine reuptake inhibitors with cannabidiol are given below.

[0060] 1. Experiment 1

[0061] Recipe Sample Set 1

[0062]

[0063]

[0064] According to the preparation methods well known to those skilled in the art, the tablets containing the above formulations are prepared.

[0065] Control group 1

[0066]

[0067] According to the preparation methods well known to those skilled in the art, the tablets containing the above formulations are prepared.

[0068] 2. Experiment 2

[0069] Recipe sample set 2

[0070]

[0071] According to the preparation methods well known to those skilled in the art, the tablets containing the above formulations are prepared.

[0072] Control group 2

[0073]

[0074] According to the preparation methods well known to those skilled in the art, ...

Embodiment 2

[0097] Example 2 Synergistic antidepressant effect of serotonin and norepinephrine reuptake inhibitors and CBD

[0098] 1. Experimental principle:

[0099] The forced swimming test, also known as the "behavioral desperation" test, is a credible animal model of depression, which is widely used to screen antidepressant drugs and study the mechanism of action of antidepressant drugs. Most antidepressants are sensitive.

[0100] 2. Experimental method:

[0101] 110 rats (about 200 g) were randomly divided into 11 groups according to gender and weight, 10 in each group, half male and half male, room temperature 22±1°C, humidity 50±10%, natural light, free access to food and water. All animals were acclimatized in the feeding environment for 5 days before starting the experiment. Before the experiment, they were fasted for 12-16 hours and had free access to food and water.

[0102] Formula sample group (combined group): in embodiment 1 (in experiment 1-5) formula sample group 1-5...

Embodiment 3

[0112] Example 3 Combination of serotonin and norepinephrine reuptake inhibitors with CBD to reduce side effects of constipation

[0113] 1. Experimental method:

[0114] 90 healthy Kunming mice, weighing 20-25 g, were randomly divided into 9 groups according to gender and weight, with 10 mice in each group, half male and half male. The room temperature is 22±1°C, the humidity is 50±10%, natural light is provided, and food and water are freely available. All the animals were acclimatized in the feeding environment for 5 days before the experiment was started, and the animals used were housed in separate cages and given a certain amount of food.

[0115] Formula sample group (combined group): in embodiment 1 (in experiment 1-4) formula sample group 1-4; Wherein, serotonin and norepinephrine reuptake inhibitor group dosage is 7mg / kg body weight, Serotonin and norepinephrine reuptake inhibitors and CBD are in accordance with the ratio of each component in formula sample group 1...

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Abstract

The invention provides a composition and applications of the composition in preventing and / or treating mental diseases, and in particular relates to a composition of a reuptake inhibitor (SNRI) of 5-hydroxytryptamine and noradrenaline and cannabidiol (CBD) and applications of the composition in preventing and / or treating depression.

Description

technical field [0001] The present invention relates to a composition and its application in the prevention and / or treatment of depression, in particular to a serotonin and norepinephrine reuptake inhibitor (SNRI) or a pharmaceutically acceptable salt thereof and cannabidiol Combinations of phenols (CBD) and their use in the prevention and / or treatment of depression. Background technique [0002] Depression is a serious medical illness that affects a person's thoughts, feelings, behaviour, emotions and physical health. Major depressive disorder, also known as clinical depression, major depressive disorder, major affective disorder, and unipolar mood disorder, can involve some combination of the following symptoms: low mood, poor concentration, insomnia, fatigue, appetite disturbances, hyperactivity Guilt and suicidal thoughts. Left untreated, depression can cause severe impairment of daily functioning and even suicide. Researchers believe that more than half of those who ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4045A61K31/05A61K45/06A61P25/24A61P25/18
CPCA61K31/05A61K31/4045A61K45/06A61K2300/00
Inventor 张可谭盺常坦然金倩
Owner HANYI BIO TECH CO LTD
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