Vc-mediated tumor targeted active oxygen self-generated nanocarrier, preparation and applications thereof

A tumor-targeting and nano-carrier technology, which is applied in the direction of anti-tumor drugs, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve simple and easy-to-operate preparation process, excellent curative effect, and good biocompatibility Effect

Inactive Publication Date: 2018-06-05
HENAN UNIV OF SCI & TECH
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] At present, magnetic nanoparticles are used to carry Vc and construct a drug delivery carrier for the self-generation of tumor-targeted reactive oxygen species, and use the generated H 2 o 2 , OH and O 2 - Oxidation to kill tumors has not been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Vc-mediated tumor targeted active oxygen self-generated nanocarrier, preparation and applications thereof
  • Vc-mediated tumor targeted active oxygen self-generated nanocarrier, preparation and applications thereof
  • Vc-mediated tumor targeted active oxygen self-generated nanocarrier, preparation and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The preparation of a Vc-mediated tumor-targeting active oxygen self-generation nanocarrier-hollow magnetic nano-ferric oxide / 1-tetradecyl alcohol / vitamin c (HMNPs@Pent@Vc), the specific steps are as follows:

[0053] Step 1. Preparation of 1-tetradecyl alcohol / vitamin c (Pent@Vc) mixed solution

[0054] Weigh 1.0g of 1-tetradecyl alcohol and 50mg of vitamin Vc into a 200mL beaker, and preheat it in a water bath at 80°C for 5 minutes, then stir it mechanically at a speed of 500rpm / min for 10 minutes, until 1- Myristyl alcohol and vitamin Vc are completely dissolved to obtain Pent@Vc, a mixed solution of 1-tetradecyl alcohol / vitamin C.

[0055] Step 2. Loading of 1-tetradecyl alcohol / vitamin c by hollow magnetic nanoparticles (HMNPs@Pent@Vc)

[0056] Weigh 0.1g of hollow magnetic nanoparticles (HMNPs) and add it to the Pent@Vc mixed solution in Example 1, use mechanical stirring at a speed of 500rpm / min to completely disperse the particles in the solution and continue st...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a Vc-mediated tumor targeted active oxygen self-generated nanocarrier, preparation and applications thereof, belonging to the field of nanobiological materials. The Vc-mediated tumor targeted active oxygen self-generated nanocarrier is prepared by encapsulating Vc or Vc analogue / derivatives into cavities of hollow magnetic nanoparticles by utilizing a thermosensitive chemical substances. A method is simple, the carrier is high in cost performance, easy in scalization, good in biocompatibility, and capable of avoiding the poor tissue penetration defect of a routine photodynamic active oxygen therapy, the prepared medicine can be applied to the active oxygen treatment of tumors, the nanocarrier is delivered to tumor parts under the magnetism guidance action, and cangenerate heat under the action of high-frequency alternating magnetic field, Vc or Vc analogue / derivatives can be released into tumor cells in a targeted manner, tumor can be killed by utilizing generated high-concentration hydrogen peroxide, the content change of active oxygen at the tumor parts can be detected by utilizing an opto-acoustic imaging system, thus being capable of realizing the visualization of the treatment process, and providing a new technology for clinical treatment of tumors.

Description

technical field [0001] The invention belongs to the field of nanobiological materials, and in particular relates to a Vc-mediated tumor-targeted active oxygen self-generation nanocarrier, its preparation and application. Background technique [0002] The use of reactive oxygen species such as peroxides, free radicals, and superoxides for tumor treatment is an important treatment option for precise tumor treatment. Usually, a laser with a certain wavelength is used to excite the photosensitive substance, and the photosensitive substance that is excited and irradiated transfers the received laser energy to the surrounding ground state oxygen to generate highly oxidizing active oxygen, superoxide, and oxygen free radicals. The DNA and mitochondria of tumor cells cause oxidative damage, thereby killing tumor cells. This type of therapy usually only irradiates the tumor with laser, so it will not damage the surrounding normal tissue cells, and the photosensitive substances are u...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/02A61K47/10A61P35/00
CPCA61K9/0009A61K9/5115A61K9/5123A61K41/00A61K41/0057
Inventor李景华胡志刚李光大黄磊冯文坡周莹刘雪婷张悦
OwnerHENAN UNIV OF SCI & TECH