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Patch used for tissue repair, main body and preparation method

A tissue repair and patch technology, applied in the direction of prosthesis, medical science, etc., can solve the problems of strong foreign body sensation, prone to tissue adhesion, poor mechanical properties, etc., to reduce foreign body sensation, prevent tissue adhesion, and improve mechanical properties. Effect

Inactive Publication Date: 2018-06-05
BEIJING MED ZENITH MEDICAL SCI CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The patch for tissue repair currently on the market has the disadvantages of poor mechanical properties, strong foreign body sensation and easy tissue adhesion because absorbable sutures are used and non-biological materials are in contact with the tissue to be repaired.

Method used

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  • Patch used for tissue repair, main body and preparation method
  • Patch used for tissue repair, main body and preparation method
  • Patch used for tissue repair, main body and preparation method

Examples

Experimental program
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Effect test

preparation example Construction

[0041] An embodiment of the present invention provides a method for preparing a patch body for tissue repair, comprising the following steps:

[0042] Obtain animal small intestinal submucosa,

[0043] The main body is obtained by compounding, pressing, stacking, drying, and suturing the submucosa of the small intestine; the suture is made of non-absorbable suture; the suture is made of polyester and / or polypropylene, and the drying is selected from Freeze or vacuum dry.

[0044] The embodiment of the present invention provides a method for preparing a patch for tissue repair, which is characterized in that it includes the following steps:

[0045] Obtain animal small intestinal submucosa,

[0046] The main body is obtained by compounding, pressing, stacking, drying, and suturing the submucosa of the small intestine; the suture is made of non-absorbable suture; the suture is made of polyester and / or polypropylene, and the drying is selected from freeze-dried or vacuum-dried...

Embodiment 1

[0090] A method for preparing a patch body for tissue repair, comprising the steps of:

[0091] Preparation of a single patch patch: the small intestinal submucosa material is cleaned, disinfected, degreased, decellularized, and virus-free in any order, and finally freeze-dried or vacuum-dried.

[0092] Wherein, the disinfection treatment is soaking the submucosa of the small intestine with a disinfectant solution at room temperature, and the volume ratio of the SIS length to the disinfectant solution is 1:1 cm / ml;

[0093] The specific disinfection method is: soak for 45 minutes with a mixed aqueous solution of 1% peracetic acid and 10% ethanol;

[0094] Thoroughly ultrasonically clean with purified water after the disinfection treatment. Purified water can be used for multiple cleanings as needed, usually 1-8 times;

[0095] Degreasing, the solvent is a mixed solution of sodium hydroxide and sodium bicarbonate with a mass percentage of solute of 5%. Every time you need to ch...

Embodiment 2

[0100] A method for preparing a patch body for tissue repair, comprising the steps of:

[0101] Preparation of a single patch patch: the small intestinal submucosa material is cleaned, disinfected, degreased, decellularized, and virus-free in any order, and finally freeze-dried or vacuum-dried.

[0102] Wherein, the disinfection treatment is to soak the submucosa of the small intestine with a disinfectant solution at room temperature, and the volume ratio of the SIS length to the disinfectant solution is 1:18 cm / ml.

[0103] The specific disinfection method is: soak in disodium edetate solution with a molar concentration of 0.03M for 5 hours;

[0104] After the disinfection treatment, thoroughly ultrasonically clean with purified water. If necessary, the purified water can be used for multiple cleanings, usually 1-8 times.

[0105] Degreasing, the solvent is a sodium hydroxide alkaline solution with a mass percentage of solute of 3%. Every time a fresh solution is changed, i...

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Abstract

The invention discloses a patch used for tissue repair, a main body and a preparation method, belonging to the technical field of tissue repair. The preparation of the main body comprises the following steps: obtaining small intestinal submucosae of an animal, compounding the small intestinal submucosae, pressing, overlaying, drying, and suturing, so that the main body is obtained, wherein a nonabsorbable suture is adopted during suturing; the suture is made from a polyester and / or polypropylene material; and freeze drying or vacuum drying is adopted during drying. The prepared patch main bodyby adopting the preparation method has the advantages of low foreign body sensation, good mechanical properties and prevention of tissue adhesion.

Description

technical field [0001] The invention relates to the technical field of tissue repair, in particular to a patch for tissue repair, a main body and a preparation method. Background technique [0002] The description of the background technology of the present invention belongs to the relevant technology related to the present invention, and is only used to illustrate and facilitate the understanding of the content of the present invention, and should not be understood as the applicant's definite or presumed that the applicant believes that the present invention was filed for the first time. prior art as of the filing date. [0003] Tissue trauma or defect is a common clinical disease, such as trauma caused by internal surgery, partial defect of organ tissue, hernia, skin injury on the body surface, etc., which seriously affects the quality of life of the patient and is a problem that must be faced and solved urgently in medicine . [0004] The patch for tissue repair current...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/36A61L27/50A61L27/58A61F2/00
CPCA61F2/0063A61L27/3629A61L27/3687A61L27/50A61L27/58
Inventor 丛敬韩改莉林子凯可大年孟坚
Owner BEIJING MED ZENITH MEDICAL SCI CORP LTD
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