Medical sponge with anti-microbial, heal-promoting and anti-adhesion functions and preparation method thereof

An anti-adhesion and sponge technology, which is applied in the field of biomedicine, can solve problems such as limitations, limited application development, and difficulties in the development and application of material compounding processes, and achieve the effects of preventing tissue adhesion, promoting wound healing, and improving practicability

Active Publication Date: 2015-12-30
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because chitosan is only soluble in weak acid solution, it also limits its application development in many aspects.
[0005] At present, there have been literature reports on the use of chitosan and PVF spong

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0051] Example 1. Preparation of medical sponge containing antibacterial, healing, and anti-adhesion functions

[0052] Follow the steps below to prepare a medical sponge with antibacterial, healing-promoting and anti-adhesion functions:

[0053] First prepare the ingredients as follows

[0054] Chitosan quaternary ammonium salt 0.2%,

[0055] Polyvinyl alcohol 12%

[0056] Sodium carbonate 4%,

[0057] Formaldehyde 4%,

[0058] 8% hydrochloric acid,

[0059] Sodium Lauryl Sulfate 0.1%.

[0060] The above-mentioned raw materials are prepared according to the following steps:

[0061] 1. Stir and dissolve 85% of the polyvinyl alcohol in water at 100°C until it becomes colorless and transparent to obtain system A; in addition, the remaining polyvinyl alcohol and chitosan quaternary ammonium salt are uniformly mixed in boiling water for 30 minutes , get system B;

[0062] 2. Cool down the system A to 60°C, slowly add formaldehyde during the stirring process, and then slow...

Example Embodiment

[0068] Example 2. Preparation of medical sponge containing antibacterial, healing, and anti-adhesion functions

[0069] Follow the steps below to prepare a medical sponge with antibacterial, healing-promoting and anti-adhesion functions:

[0070] First prepare the ingredients as follows

[0071] Chitosan Quaternary Ammonium Salt 0.1%,

[0072] Polyvinyl alcohol 15%

[0073] Sodium carbonate 5%,

[0074] Formaldehyde 5%,

[0075] 10% hydrochloric acid,

[0076] Sodium Lauryl Sulfate 0.5%.

[0077] The above-mentioned raw materials are prepared according to the following steps:

[0078] 1. Stir and dissolve 90% of the polyvinyl alcohol in water at 100 °C until it becomes colorless and transparent to obtain system A; in addition, the remaining polyvinyl alcohol and chitosan quaternary ammonium salt are mixed in boiling water for 30 minutes. , get system B;

[0079] 2. Cool down the system A to 55°C, slowly add formaldehyde during the stirring process, and then slowly add ...

Example Embodiment

[0085] Example 3. Preparation of medical sponge containing antibacterial, healing, and anti-adhesion functions

[0086] Follow the steps below to prepare a medical sponge with antibacterial, healing-promoting and anti-adhesion functions:

[0087] First prepare the ingredients as follows

[0088] Chitosan Quaternary Ammonium Salt 0.4%,

[0089] 10% polyvinyl alcohol

[0090] Sodium carbonate 2%,

[0091] Formaldehyde 2%,

[0092] 5% hydrochloric acid,

[0093] Sodium Lauryl Sulfate 0.02%.

[0094] The above-mentioned raw materials are prepared according to the following steps:

[0095] 1. Stir and dissolve 80% of the polyvinyl alcohol in water at 100 °C until it becomes colorless and transparent to obtain system A; in addition, the remaining polyvinyl alcohol and chitosan quaternary ammonium salt are uniformly mixed in boiling water for 30min , get system B;

[0096] 2. Cool down the system A to 60°C, slowly add formaldehyde during the stirring process, and then slowly ...

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PUM

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Abstract

The invention discloses a medical sponge with anti-microbial, heal-promoting and anti-adhesion functions and a preparation method thereof. The medical sponge is prepared by the following ingredients in mass percent: 0.1-0.5 percent of chitosan quaternary ammonium salt, 10-15 percent of polyving akohol, 2-5 percent of foaming agent, 2-5 percent of cross-linking agent, 5-10 percent of inorganic acid catalyst, 0.02-0.5 percent of surface active agent, and the balance of water. In addition, the preparation method comprises the following steps of dividing the polyving akohol into two groups, commonly dissolving one group of polyving akohol and the water-soluble chitosan quaternary ammonium salt, and then carrying out copolymerization on the dissolved solution and independently reaction polymerized components to form a finished product. The medical sponge has a series of excellent properties of anti-microbial, stopping bleeding and stopping pain, and is capable of absorbing seepage, preventing tissue adhesion, promoting granulation tissue hyperplasia, promoting wound healing, preventing scars, favorable biocompatibility and the like; meanwhile, the used chitosan quaternary ammonium salt not only solves the problem of limitation that chitosan can only be dissolved in chitosan quaternary ammonium salt, but also has better anti-microbial performance than chitosan, and the medical practicability of the PVF (Polyvinyl Fluoride) sponge is greatly improved.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a medical sponge with antibacterial, healing-promoting and anti-adhesion functions and a preparation method thereof. Background technique [0002] The currently used spongy wound dressings are mainly polymers such as polyurethane (PU) and polyvinyl formal (PVF), among which PVF is most widely used. PVF foam is a white foam with an open cell structure. In the dry state, the foam is a hard plastic with good mechanical properties and can be machined. It has excellent hydrophilicity and can quickly absorb water. Its absorption capacity is much higher than that of general water-absorbing materials, such as: cotton yarn, paper, etc. Quickly absorbs up to 20 times its own weight in water. After absorbing water, in a wet state, it becomes a soft, strong, wear-resistant and resilient elastic sponge. PVF foam does not promote the growth of bacteria, is not corroded by mold, has go...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/26A61L15/44A61L15/46C08J9/08
Inventor 赵澎陈良艳侯长斌
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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