Medical sponge with anti-microbial, heal-promoting and anti-adhesion functions and preparation method thereof

Abstract

The invention discloses a medical sponge with anti-microbial, heal-promoting and anti-adhesion functions and a preparation method thereof. The medical sponge is prepared by the following ingredients in mass percent: 0.1-0.5 percent of chitosan quaternary ammonium salt, 10-15 percent of polyving akohol, 2-5 percent of foaming agent, 2-5 percent of cross-linking agent, 5-10 percent of inorganic acid catalyst, 0.02-0.5 percent of surface active agent, and the balance of water. In addition, the preparation method comprises the following steps of dividing the polyving akohol into two groups, commonly dissolving one group of polyving akohol and the water-soluble chitosan quaternary ammonium salt, and then carrying out copolymerization on the dissolved solution and independently reaction polymerized components to form a finished product. The medical sponge has a series of excellent properties of anti-microbial, stopping bleeding and stopping pain, and is capable of absorbing seepage, preventing tissue adhesion, promoting granulation tissue hyperplasia, promoting wound healing, preventing scars, favorable biocompatibility and the like; meanwhile, the used chitosan quaternary ammonium salt not only solves the problem of limitation that chitosan can only be dissolved in chitosan quaternary ammonium salt, but also has better anti-microbial performance than chitosan, and the medical practicability of the PVF (Polyvinyl Fluoride) sponge is greatly improved.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a medical sponge with antibacterial, healing-promoting and anti-adhesion functions and a preparation method thereof. Background technique [0002] The currently used spongy wound dressings are mainly polymers such as polyurethane (PU) and polyvinyl formal (PVF), among which PVF is most widely used. PVF foam is a white foam with an open cell structure. In the dry state, the foam is a hard plastic with good mechanical properties and can be machined. It has excellent hydrophilicity and can quickly absorb water. Its absorption capacity is much higher than that of general water-absorbing materials, such as: cotton yarn, paper, etc. Quickly absorbs up to 20 times its own weight in water. After absorbing water, in a wet state, it becomes a soft, strong, wear-resistant and resilient elastic sponge. PVF foam does not promote the growth of bacteria, is not corroded by mold, has go...

AI Technical Summary

Problems solved by technology

However, because chitosan is only soluble in weak acid solution, it also limits its application development in many aspects.

[0005] At present, there have been literature reports on the use of chitosan and PVF sponge to form composite materials. However, since chitosan itself is only soluble in weak acid solutions, it brings difficulties and limitations to the material composite process and further development and application.