Freeze-drying flash release tablet for local skin anaesthesia, as well as preparation method and application thereof

Abstract

The invention relates to the technical field of medical anesthesia, in particular to a freeze-drying flash release tablet for local skin anaesthesia, as well as a preparation method and application thereof. The freeze-drying flash release tablet is packaged in a double-aluminum-film cavity in a sealed way, and comprises the following raw materials in parts by weight: 10 to 25 parts of compound anesthetic, 10 to 20 parts of a nanometer photocatalyzer, 15 to 25 parts of a freezing and drying protecting agent, 3 to 8 parts of granulesten, 2 to 5 parts of hydroxypropyl methyl cellulose, and 10 to15 parts of polyethylene glycol, wherein the compound anesthetic adopts liposome taking anesthetic as a core and coated by a lipid layer and a hydrophilic protective layer from the inner part to the outer part. In addition, the invention further discloses a preparation method and application of the freeze-drying flash release tablet. The freeze-drying flash release tablet has the advantages that the lipid layer is taken as an anesthetic carrier, the hydrophilic protective layer is taken as an anesthetic protective layer, then the freeze-drying flash release tablet is formed, the permeability of anesthetic can be enhanced, the anesthetic effects of rapidness, effectiveness, safety and no stimulation are achieved, antibiosis disinfection is performed through the nanometer photocatalyzer, andanesthesia and sterilization and disinfection are performed at the same time.

Description

technical field [0001] The invention relates to the technical field of medical anesthesia, in particular to a freeze-dried flash-release tablet for local skin anesthesia and a preparation method thereof. Background technique [0002] Anesthesia is the use of drugs or other methods to temporarily deprive the patient of sensation in whole or in part, so as to achieve painless surgical treatment. Regarding anesthesia technology, the earliest written record in the world is Mabo Decoction, which appeared in the Han Dynasty in my country, and was invented by Hua Tuo, a famous ancient Chinese surgeon and Chinese medicine scientist. Mabo Decoction is a traditional Chinese medicine decoction equivalent to the current oral general anesthesia. After oral administration, the patient loses skin sensation and facilitates the operation. Later, Western medicine invented various anesthetics, such as lidocaine, bupivacaine, procaine, etc., which are popular now. [0003] Epidermal anesthesi...

AI Technical Summary

Problems solved by technology

[0004] In clinical practice, in order to shorten the waiting time for anesthesia to take effect, after applying anesthesia ointment on the skin, the area is further sealed with plastic wrap to promote the absorption of the anesthetic. However, this method of wrapping with plastic wrap is not only troublesome, but also effective The waiting time is still too long, generally about an hour. While waiting for the anesthetic to take effect for a long time, it will virtually increase the anxiety of the surgical patient, and bacteria are likely to be produced on the surface of the skin during the long waiting process.