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Aortic dissection detecting marker and marker evaluation method

A technology of aortic dissection and markers, applied in the field of medicine, can solve the problems of poor practicability and low accuracy of AAD diagnosis

Pending Publication Date: 2018-06-19
THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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Problems solved by technology

[0016] The existing markers of aortic dissection are used for the early diagnosis and prognosis evaluation of AAD, and the diagnostic accuracy and practicability of AAD are low in clinical application

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  • Aortic dissection detecting marker and marker evaluation method
  • Aortic dissection detecting marker and marker evaluation method
  • Aortic dissection detecting marker and marker evaluation method

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Embodiment Construction

[0049] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0050] The present invention detects the concentration levels of serum cyclophilin A and matrix metalloproteinase-12 in patients with acute aortic dissection (AAD), analyzes their feasibility as early diagnostic markers for AAD, and combines relevant serum markers to find the best Combined diagnostic formula.

[0051] Methods: The present invention selected 60 cases of patients with aortic dissection who were diagnosed with aortic dissection by aortic CTA from January 2015 to March 2016 in the First Affiliated Hospital of Xinjiang Medical University as the case group, and 28 cases of healthy control subjects in the same per...

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Abstract

The invention belongs to the technical field of medicine and discloses an aortic dissection detecting marker and a marker evaluation method. The aortic dissection detecting marker is MMP-9+D-Dimer+ET-1+Calponi. The evaluation method comprises the following steps: performing serological analysis on the selected marker MMP-9+D-Dimer+ET-1+Calponi with ELISA; drawing a ROC (receiver operating characteristic) curve and adopting statistical software SPSS21.0 for analysis. Specificity of three indexes including ET-1, D-Dimer and MMP-9 are higher and are 98.6%, 98.7% and 97.1% respectively, sensitivity of the three indexes are 80.0%, 81.7% and 81.7%, and diagnostic accuracy of the three indexes are also higher and are 86.4%, 87.5% and 87.5%.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a marker for detecting aortic dissection and a marker evaluation method. Background technique [0002] Acute aortic dissection is a type of acute aortic syndrome, a type of cardiovascular emergency with a high mortality rate. Based on the current analysis, it is found that the main mechanism of AAD is the sudden fatal pathological changes of the aortic vessel wall. The local damage of the vessel wall makes the blood enter the aortic intima under extremely high pressure and involve the middle layer, thereby causing Interlayer between intima and media. The clinical manifestations of these patients are mostly sudden tearing chest and back pain. In the early stage of the disease, most patients died of aortic adventitia rupture due to severe dissection. In addition, due to the formation of a false lumen in aortic dissection, some patients will gradually affect the bloo...

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/329
Inventor 马翔成娜汪浩
Owner THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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