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Overground danshen stem and leaf extract with function of conditioning intestinal tracts and preparation method and application thereof

A technology of salvia stems and leaves and intestinal function is applied in the field of Salvia miltiorrhiza stem and leaf extract and its preparation, which can solve the problems of salvia miltiorrhiza discarding, environment and resource waste, and achieve no intestinal toxicity, good safety, good clinical application value and The effect of environmental value

Inactive Publication Date: 2018-07-06
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the increasing demand of Salvia miltiorrhiza, the resources of wild Salvia miltiorrhiza are on the verge of depletion. The applicant's previous research shows that the aboveground stems and leaves of Salvia miltiorrhiza contain rich salvianolic acid chemical components, especially salvianolic acid B and rosmarinic acid, and the aboveground salvia miltiorrhiza The stems and leaves account for about 67% of the whole plant and are rich in resources, but they are often discarded in the development and utilization of Danshen, resulting in a great waste of resources and environmental problems

Method used

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  • Overground danshen stem and leaf extract with function of conditioning intestinal tracts and preparation method and application thereof
  • Overground danshen stem and leaf extract with function of conditioning intestinal tracts and preparation method and application thereof
  • Overground danshen stem and leaf extract with function of conditioning intestinal tracts and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] In the preparation method of the stem and leaf extract from the above ground of Salvia miltiorrhiza, it comprises the following steps:

[0021] (1) Take 50g dry powder (water content of 9.64%) of the aboveground stems and leaves of Salvia miltiorrhiza, use water and different concentrations of ethanol (20%, 40%, 60%, 80% and 95%) as extraction solvents, and extract the aboveground stems of Salvia miltiorrhiza The leaves were subjected to reflux extraction twice, each extraction time was 1.5h, and filtered; the weight-to-volume ratio of the stems and leaves of Salvia miltiorrhiza to the extraction solvent was 1:10.

[0022] (2) Combine the two filtrates, concentrate, and measure the content of phenolic acid. The results of ultra-high performance liquid chromatography showed that the content of various components extracted by 60% ethanol was relatively high, among which the content of phenolic acid components was 5.28%, the content of flavonoid components was 0.37%, and t...

Embodiment 2

[0024] In the preparation method of the extract from aboveground stems and leaves of Salvia miltiorrhiza, it comprises the following steps:

[0025] Get 50g dry powder (water content is 9.64%) of aboveground cauline and leaf of Salvia miltiorrhiza, carry out reflux extraction 2 times to the aboveground cauline and leaf of Salvia miltiorrhiza with ethanol of volume concentration 60%, each extraction time 1.5h, filter; Salvia miltiorrhiza stem and leaf and ethanol The weight to volume ratio is 1:10.

Embodiment 3

[0026] Example 3 Experiment on the protective effect of diabetic intestinal complications

[0027] 1. Experimental method

[0028] Male C57BL / 6 mice with a body weight of 20±2g were selected. After the animals had adapted to the environment for 1 week, diabetes models were established, and 100 mice were randomly selected for type I diabetes by intraperitoneal injection of 120mg / kg streptozotocin (STZ). Diabetes modeling, after 7 days of modeling, the successful model mice were randomly divided into groups for administration, and the experiment was divided into: model group, positive drug group (aminoguanidine 100 mg / kg), low dose group of aboveground stem and leaf extract of salvia miltiorrhiza in Example 2 (150mg / Kg), the high-dose group (300mg / Kg) of the aboveground stem and leaf extract of Salvia miltiorrhiza in Example 2, 20 in every group. Another 20 normal mice were used as blank control group.

[0029] The aerial stems and leaves of Salvia miltiorrhiza were prepared i...

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Abstract

The invention discloses overground danshen stem and leaf extract with a function of conditioning intestinal tracts and a preparation method and application thereof. The method can fully utilize overground stem and leaf resources of non-officinal parts which are deserted in a planting process of danshen, and the extract is prepared by an optimized extraction preparation technology. Experimental results show that the overground danshen stem and leaf extract provided by the invention can significantly enhance intestinal barrier of mice under a pathological state and regulate intestinal flora, andhas no toxicity to the intestinal barrier and intestinal flora of normal organisms. The overground danshen stem and leaf extract provided by the invention has a health-care function of conditioning intestinal functions, and can be used as a medicine or a intestine nutrition agent health food for conditioning diabetes intestinal complications or other intestinal diseases and resisting gastrointestinal barrier injuries.

Description

technical field [0001] The invention relates to a new natural food resource, in particular to a stem and leaf extract of salvia miltiorrhiza with the function of regulating intestinal tract, its preparation method and application. Background technique [0002] Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bge., a plant of the genus Lamiaceae. It is a famous traditional Chinese medicine for promoting blood circulation and removing blood stasis, and is widely used in the treatment of cardiovascular and cerebrovascular diseases and diabetic complications. Salvianolic acid is the main active ingredient of Salvia miltiorrhiza, which has strong anti-lipid peroxidation and free radical scavenging effects. Recent studies have further shown that salvianolic acid can significantly reduce blood sugar, total cholesterol and triglyceride levels, and increase The role of insulin sensitivity in DM rats. With the increasing demand of Salvia miltiorrhiza, the resour...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A61K36/537A61P1/00A61P3/10A61K135/00A61K127/00
CPCA23L33/105A23V2002/00A61K36/537A61K2236/333A61K2236/39A61K2236/51A23V2200/32
Inventor 段金廒顾俊菲宿树兰朱悦钱大玮唐志书
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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