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Hydrogel composite device for ionizing radiation dose measurement and its preparation method

A technology of dose measurement and ionizing radiation, applied in radiation measurement, radiation therapy, X-ray/γ-ray/particle irradiation therapy, etc., can solve the problem of weak adhesion, low adhesion tightness, low mechanical strength and elongation, etc. problems, to achieve the effects of excellent mechanical properties and adhesion properties, high sensitivity and precision, non-toxic biocompatibility

Active Publication Date: 2019-12-31
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current TLD has the following disadvantages in the application: due to factors such as the human body surface movement caused by breathing and the inherent dose distribution gradient, the accuracy of the ionizing radiation dose measured by a single TLD is low, and the ionizing radiation dose distribution in a wide range cannot be obtained Information; Dense TLD directly pasted on the elastic and uneven skin surface will cause discomfort and skin inflammation, and the tightness of the paste is low
At present, there is no composite device of hydrogel and TLD, and ordinary hydrogel materials have defects such as low mechanical strength and ductility, weak adhesion, etc., and cannot be used as a carrier for adhering skin and TLD

Method used

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  • Hydrogel composite device for ionizing radiation dose measurement and its preparation method
  • Hydrogel composite device for ionizing radiation dose measurement and its preparation method
  • Hydrogel composite device for ionizing radiation dose measurement and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 70mmol AAm, 12mmolAAc and 12mmol PDADMAC were mixed and dissolved in 30mL of deionized water, then 0.07mmol of photoinitiator Irgacure 2959 was added to the mixed solution, ultrasonic vibration and nitrogen gas was passed for 40 minutes to remove dissolved oxygen in the solution, and then the mixed solution was Sealed and placed in front of a UV light source for irradiation, the irradiation intensity is 8.5mW / cm 2After irradiating for 10 minutes, quickly place the lithium fluoride thermoluminescent dosimeter on the surface of the prepolymer gently to make it naturally wet and float on the surface, and continue to irradiate with the same light intensity for 60 minutes to obtain ionizing radiation dose measurement. hydrogel composite devices.

Embodiment 2

[0041] The hydrogel composite device was prepared according to the method of Example 1, except that the amount of AAm was 40 mmol.

Embodiment 3

[0043] The hydrogel composite device was prepared according to the method of Example 1, except that the amount of AAm was 50 mmol.

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Abstract

The invention relates to a preparation method of a hydrogel composite device for measuring the ionizing radiation dose. The preparation method of the hydrogel composite device for measuring the ionizing radiation dose comprises the following steps: mixing acrylamide, an anionic monomer and a polycationic matrix with a photoinitiator in water to remove oxygen from a mixed solution, then polymerizing by ultraviolet irradiation, and irradiating for 1 to 30 min to obtain a prepolymer; placing a thermoluminescent dosemeter (TLD) on the surface of the prepolymer, and irradiating continuously with ultraviolet light to completely polymerize the prepolymer, thus forming the hydrogel composite device for measuring the ionizing radiation dose. The invention further requires to protect the hydrogel composite device for measuring the ionizing radiation dose prepared by the preparation method. The method disclosed by the invention closely combines hydrogel with excellent mechanical properties and adhesion properties with the TLD, so that the device can be closely adhered to the surface of skin to accurately measure the ionizing radiation dose.

Description

technical field [0001] The invention relates to the technical field of medical polymer materials and ionizing radiation measurement, in particular to a hydrogel composite device for ionizing radiation dose measurement and a preparation method thereof. Background technique [0002] Tumors seriously endanger the health and survival of human beings. As one of the main means of tumor treatment, the development of radiotherapy technology has put forward higher and higher requirements for the accuracy of its treatment. Especially for patients with head and neck, chest tumors and skin cancer, detecting the dose of ionizing radiation on the skin surface can help confirm the actual distribution of the dose, avoid skin inflammation and side effects caused by excessive doses of radiation therapy, and help improve radiation therapy. Precision of treatment planning and its quality control. [0003] Thermoluminescence dosimeter (TLD) is a solid with a crystal structure, because it contai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F271/00C08F220/56C08F220/06G01T7/00A61N5/10
CPCA61N5/1048C08F271/00G01T7/00C08F220/56
Inventor 胡亮李文翔刘汉洲文万信
Owner SUZHOU UNIV
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