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Method for simultaneously determining contents of a variety of components in Xinkeshu tablet

A content and weight technology, which is applied in the direction of measuring devices, material separation, and analysis of materials, can solve the problems of inability to fully reflect the quality of compound preparations, simple roughness, etc., achieve the best analysis effect, high theoretical plate number, and ensure clinical The effect of curative effect

Active Publication Date: 2018-07-13
SHANDONG WOHUA PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the existing methods are relatively simple and rough, and cannot fully reflect the quality of the compound preparation

Method used

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  • Method for simultaneously determining contents of a variety of components in Xinkeshu tablet
  • Method for simultaneously determining contents of a variety of components in Xinkeshu tablet
  • Method for simultaneously determining contents of a variety of components in Xinkeshu tablet

Examples

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Effect test

experiment example

[0049] Experimental Example: Simultaneous determination of the contents of 7 index components in Xinkeshu Tablets.

[0050] 1. Instruments, reagents and samples:

[0051] 1.1 Instruments:

[0052] ACQUITY UPLC H-CLASS ultra-high performance liquid chromatography (Waters, USA), C18 1.7μm 1.0×50mm COL column (Waters, USA), diode array detector (DAD), Empower MassLynx chromatography workstation; METTLER AE240 electronic Libra (Mettler-Toledo Instruments (Shanghai) Co., Ltd.); KQ-250E Ultrasonic Cleaner (Kunshan Ultrasonic Instrument Co., Ltd.); SENCO W2018 Constant Temperature Water Bath (Shanghai Shensheng Technology Co., Ltd.); IKA RV05 Basic Type 1-B rotary evaporator (German IKA Group); SHB-3A multi-purpose circulating water vacuum pump (Shanghai Yarong Biochemical Instrument Factory); SZ-93 automatic double pure water distiller (Shanghai Yarong Biochemical Instrument Factory).

[0053] 1.2 Reagents:

[0054] Methanol (chromatographically pure, American Tedia Reagent Company...

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Abstract

The invention belongs to the field of quality control of traditional Chinese medicine, and relates to a method for simultaneously determining the contents of a variety of components in a Xinkeshu tablet. Specifically the method comprises: 1) preparing a test substance solution by using a Xinkeshu tablet; 2) respectively preparing reference substance solutions by using 7 index components (such as sodium danshensu, protocatechualdehyde, salvianolic acid B, ursolic acid, hyperoside, costunolide and puerarin); 3) setting UPLC detection conditions; and 4) determining. With the method of the presentinvention, the contents of the 7 index components can be simultaneously determined. According to the present invention, the method is simple, rapid and accurate, can solve the defect that a variety of components cannot be simultaneously determined in the prior art, has advantages of short peal appearing time, saved determination time and improved working efficiency, is especially suitable for online quality control and detection, further has advantages of toxic solvent consumption reducing and environmental protection, and can improve the safety, the effectiveness and the controllability of preparations so as to ensure the clinical treatment effects of preparations and the health of patients.

Description

technical field [0001] The invention belongs to the field of quality control of traditional Chinese medicines, and relates to a method for simultaneously measuring the contents of various components in Xinkeshu tablets, and simultaneously measured danshensu sodium, protocatechualdehyde, salvianolic acid B, and bearberry in Xinkeshu tablets. acid, hyperin, coynelide and puerarin content. Background technique [0002] Xinkeshu tablet is the exclusive product of Shandong Wohua Pharmaceutical Technology Co., Ltd., which consists of Danshen (with danshensu sodium, protocatechualdehyde and salvianolic acid B as index components), Panax notoginseng (with ursolic acid as index components) ), hawthorn (with hyperoside, etc. as index components), kudzu root (with puerarin as index components), woody fragrance (with woody lactone as index components) 5 traditional Chinese medicines, which have the functions of promoting blood circulation and removing blood stasis , the effect of promo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/34G01N30/74G01N30/06G01N30/14
CPCG01N30/02G01N30/06G01N30/14G01N30/34G01N30/74G01N2030/146
Inventor 周万辉曾英姿王冬梅于洪亮赵磊
Owner SHANDONG WOHUA PHARMACEUTICALS CO LTD
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