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Bufalin micelle nano-preparation and preparation method thereof

A technology of micellar nanometer and bufalin, which is applied in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problem of difficulty in adding functional groups, cytotoxicity, and bufalin. It does not meet the screening conditions of new anti-cancer drug candidate compounds and other problems, and achieves the effect of facilitating binding and drug release, increasing water solubility, and improving bioavailability

Active Publication Date: 2018-07-20
THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST +1
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Benefits of technology

This patented new type of nanopositioning agent called bimodal poly(ammonium salts), which consisting of two different types of molecules - one with polar groups that are attached to each other while another group does not have them, was developed for use in studying biological processes such as cell growth or gene expression regulated through interactions between proteins. These agents were found effective against tumors due to their ability to deliver drugs specifically into these areas without causing harmful side reactions like chemotherapy. Additionally, this material could be used effectively towards treatments aimed toward prevention of metastasis.

Problems solved by technology

The technical problem addressed in this patents relates to improving the properties or functions of small chemicals used as drugs through their incorporated polymer network structures. These networks help deliver these substances more efficiently with reduced side effects compared to traditional methods like liposomes.

Method used

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  • Bufalin micelle nano-preparation and preparation method thereof
  • Bufalin micelle nano-preparation and preparation method thereof
  • Bufalin micelle nano-preparation and preparation method thereof

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Embodiment Construction

[0020] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention clearer, the present invention will be further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0021] Due to poor water solubility, high toxicity, short half-life in vivo, and poor bioavailability, bufalin alone is difficult to use as a drug. However, conventional non-peptide dendrimer drug carriers are too cytotoxic, have high potential risks, and are not conducive to structural modification. Therefore, after a long-term research and development process, the inventors of the present invention have proposed a technical solution that bufalin is expected to be used in clinical medicine.

[0022] combine Figure 1-6 , an embodiment of the present invention provides a bufalin micelle n...

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Abstract

The invention provides a bufalin micelle nano-preparation. The bufalin micelle nano-preparation comprises bufalin, and a lipidized polypeptide micelle carrier which wraps the bufalin, and one moleculeof the lipidized polypeptide micelle carrier comprises one molecule of a hydrophilic unit and one molecule of a hydrophobic unit connected with the hydrophilic unit, wherein the hydrophilic unit is an asymmetric dendritic polypeptide polymer unit, the hydrophobic unit is a lipid unit, and the end of the dendritic polypeptide polymer unit carries a positive charge.

Description

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Claims

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Application Information

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Owner THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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