Traditional Chinese medicine composition for treating diseases caused by human papilloma virus and preparation method and applications thereof

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve the problems of high toxicity and side effects, interruption of use, temporary cure but not the root cause, etc., and achieve the effect of simple preparation method, inhibition of nucleic acid replication, and definite curative effect

Active Publication Date: 2018-07-24
BEIJING ZHONGKE PAITE BIOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Injection of interferon, its toxic and side effects, long course of treatment, low cure rate, difficult to popularize
[0005] With the deepening of clinical research, some drugs for the treatment of the diseases caused by human papillomavirus have appeared on the market. Use of expensive ingredients, some discontinued during application due to uncertain efficacy

Method used

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  • Traditional Chinese medicine composition for treating diseases caused by human papilloma virus and preparation method and applications thereof
  • Traditional Chinese medicine composition for treating diseases caused by human papilloma virus and preparation method and applications thereof
  • Traditional Chinese medicine composition for treating diseases caused by human papilloma virus and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Composition and preparation method of embodiment 1 Chinese medicine composition

[0050] [composition]

[0051] 38 parts of Smilax cocos, 19 parts of Sophora flavescens, 30 parts of Hedyotis diffusa, 30 parts of dandelion, 15 parts of star anise lotus, 19 parts of honeycomb, 30 parts of Cortex Cortex, 6 parts of Brucea javanica, 19 parts of Fructus Cnidii, 7 parts of licorice, honeysuckle 19 parts, 19 parts of Daqingye, 13 parts of Tiankuizi, 1500 parts of 75% ethanol.

[0052][Preparation]

[0053] (1) Soak 15 parts of star anise lotus, 19 parts of honeycomb, 6 parts of Brucea javanica, 19 parts of honeysuckle, and 13 parts of geranium seeds, soak them in 95% ethanol for 10 days, take the supernatant, and extract with 0.04Mpa alcohol at 65°C Concentrate to obtain the alcohol extraction concentrate;

[0054] (2) With 38 parts of Smilax smilax, 19 parts of Sophora flavescens, 30 parts of Hedyotis diffusa, 30 parts of Dandelion, 30 parts of Cortex Phellodendri, 19 part...

Embodiment 2

[0057] Example 2 The traditional Chinese medicine composition of the present application inhibits human papillomavirus nucleic acid replication in vitro

[0058] 1. Clinical collection of genital tract genital wart specimens, a total of 30 copies. After homogenization, human papillomavirus (HPV) nucleic acid DNA was extracted.

[0059] 2. choose the Chinese medicine composition that embodiment 1 prepares, make it 5%, 2.5%, 1.25%, 0.625% and 0.3125% dilution, act two times, be respectively 34 hours and 58 hours, test temperature is 25°C. Normal saline was used as negative control.

[0060] 3. Conclusion:

[0061] Action for 34 hours: No nucleic acid can be detected in the traditional Chinese medicine composition with a concentration ≥ 2.5%; 6.67% can detect nucleic acid when the concentration is 1.25%; 50% can detect nucleic acid when the concentration is 0.625%; 93.33% can detect nucleic acid when the concentration is 0.3125% Nucleic acid can be detected;

[0062] 58 hour...

Embodiment 3

[0065] Embodiment 3 The Chinese medicine composition of the present application treats condyloma acuminatum

[0066] 1. Select the cases of genital warts of male and female aged 18-65: the diameter of a single wart is <0.5cm, the number of warts is <5 (the diameter of wart mass is <1cm), and the warts are located in external causes or perianal parts. The test group and the control group consisted of 30 people each. The test group used the traditional Chinese medicine composition prepared in Example 1 of the present application, and the control group used imiquimod cream.

[0067] Exclusion criteria: patients with skin diseases that affect the evaluation; patients with severe liver and kidney dysfunction; patients allergic to imiquimod cream; patients who have received virus treatment.

[0068] 2. Test method:

[0069] Test group: the medicinal composition prepared in Example 1 of the present application was dipped with a cotton swab, and applied to the wart and the surroundin...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating diseases caused by human papilloma virus and a preparation method and applications thereof. The traditional Chinese medicine composition comprises following components in parts by weight: 15 to 60 parts of smilax glabra, 7.5 to 30 parts of sophora flavescens, 10 to 40 parts of oldenlandia diffusa, 10 to 40 parts of dandelion, 6 to 24 parts of dysosma versipellis, 7.5 to 30 parts of nidus vespae, 10 to 40 parts of phellodendron, 2.5 to 10 parts of brucea javanica, 7.5 to 30 parts of fructus cnidii, 3 to 12 parts oflicorice root, 7.5 to 30 parts of honeysuckle flower, 7.5 to 30 parts of folium isatidis, 5 to 20 parts of radix semiaquilegiae, and 1000 to 2000 parts of ethanol (75%). The provided traditional Chinese medicine composition has good druggability and definite curative effect and is very safe.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine composition for treating diseases caused by human papillomavirus, a preparation method and application thereof. Background technique [0002] Human papillomavirus (Humanpapillomavirus, HPV) is an epitheliophilic virus, a member of the Papovaviridae genus A, a small DNA virus that infects the epidermis and mucosal squamous epithelium, with a diameter of 52-55 nm and no capsule. It has a regular 20-hedron structure, with 72 shells on the surface, and the viral genome is a double-stranded circular DNA molecule, which is widely distributed in humans and has a high degree of specificity. More than 100 subtypes of HPV have been found so far. Low-risk HPV can cause a variety of benign lesions on the skin and mucous membranes, such as genital warts and skin warts. High-risk HPV is the leading cause of cervical cancer. Cervical cancer is one of the mos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/896A61P31/20A61P17/12A61P35/00A61P17/00A61K35/64
CPCA61K35/63A61K36/185A61K36/195A61K36/234A61K36/288A61K36/29A61K36/315A61K36/355A61K36/484A61K36/489A61K36/704A61K36/71A61K36/748A61K36/756A61K36/855A61K36/896A61K36/90A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 杜转社
Owner BEIJING ZHONGKE PAITE BIOTECH
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