Device for generating fluid shear force and method for generating fluid shear force
A technology of fluid shear force and generation device, which is applied in measurement devices, fluid controllers, chemical instruments and methods, etc., can solve the problems of inability to simulate the magnitude of fluid shear force, and inability to dynamically adjust the magnitude and ratio of fluid shear force. , to achieve the effect of easy promotion, simple structure, and extended ratio range
Active Publication Date: 2020-01-14
HARBIN INST OF TECH SHENZHEN GRADUATE SCHOOL
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Problems solved by technology
[0009] In order to overcome the deficiencies of the prior art, the present invention proposes a fluid shear force generating device and a fluid shear force generating method, which are used to solve the problem that the existing shear force generating device 1) cannot simulate the fluid shear force inside all blood vessels of the human body and 2) the problem that it is impossible to dynamically adjust the size and ratio of the fluid shear force in each flow channel without changing the input fluid velocity
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[0037] The idea, specific structure and technical effects of the present invention will be clearly and completely described below in conjunction with the embodiments and accompanying drawings, so as to fully understand the purpose, scheme and effect of the present invention. It should be noted that, in the case of no conflict, the embodiments in the present application and the features in the embodiments can be combined with each other.
[0038] It should be noted that, unless otherwise specified, when a feature is called "fixed" or "connected" to another feature, it can be directly fixed and connected to another feature, or indirectly fixed and connected to another feature. on a feature. In addition, descriptions such as up, down, left, right, front, and back used in the present invention are only relative to the mutual positional relationship of the components of the present invention in the drawings.
[0039] Also, unless defined otherwise, all technical and scientific ter...
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The present invention relates to the field of micro-fluidic chips. Disclosed are a fluid shear stress generation device and a fluid shear stress generation method. The device comprises a device body; a main flow passage and at least two branch flow passages are provided on the device body; the two ends of the main flow passage are provided with a fluid inlet and a main flow passage fluid outlet; one end of each branch flow passage is communicated with the main flow passage, and the other end is provided with a branch flow passage fluid outlet; valves capable of regulating cross sectional areas in the branch flow passages to allow fluid to pass through are provided in the branch flow passages. According to the present invention, by means of the cooperation of the main flow passage, the branch flow passages, and the valves, dynamic changes of the magnitudes and ratio of fluid shear stresses can be achieved without changing the flow velocity of input fluid and the structure of the device. In addition, the present invention can greatly expand the range of the ratio of the fluid shear stresses in first and final branch flow passages; moreover, the ratio at any point in the range can be covered. The device is simple in structure, and easy to popularize and implement.
Description
technical field [0001] The invention relates to the field of microfluidic chips, in particular to a fluid shear force generation device capable of realizing wide range and dynamic adjustment of fluid shear force in a flow channel, and a method for generating fluid shear force. Background technique [0002] There is a complex vascular system distributed in the human body, with diameters ranging from a few micrometers to several centimeters. The fluid shear force formed by blood flow in veins and arteries is about 0.7-9dyn / cm respectively 2 and 20-70dyn / cm 2 . Shear forces sometimes exceed 450 dyn / cm in narrowed arterial vessels 2 . Blood flow shear stress is closely related to a series of complex biological processes in the human body. Simulating this complex shear stress environment in an in vitro model is of great significance for the study of endothelial cell function, cardiovascular disease and thrombus, etc. [0003] As early as the 1980s, parallel plate flow chamb...
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IPC IPC(8): B01L3/00
CPCB01L3/5027B01L3/50273B01L3/502738B01L3/502746B01L3/502776B01L2300/0864B01L2400/0655B01L2400/082G01N33/4915
Inventor 陈华英陈畅朱永刚于志航
Owner HARBIN INST OF TECH SHENZHEN GRADUATE SCHOOL