Cannabinoid-containing oral pharmaceutical composition, method for preparing and using same

A technology of cannabinoids and compositions, applied in the field of refractory epilepsy, can solve problems such as no detailed technology

Inactive Publication Date: 2018-08-03
PRATI DONADUZZI & CIA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] However, these documents express these drugs in very general terms without detailing these aspects of the technology involved and the difficulties a skilled person will encounter in developing such formulations
Furthermore, most of the experimental data were performed in rats and mice by intraperitoneal injection, which is not a feasible method in humans

Method used

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  • Cannabinoid-containing oral pharmaceutical composition, method for preparing and using same
  • Cannabinoid-containing oral pharmaceutical composition, method for preparing and using same
  • Cannabinoid-containing oral pharmaceutical composition, method for preparing and using same

Examples

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Embodiment Construction

[0026] The examples presented herein are intended to illustrate only some of the many embodiments of the invention and thus should not be considered as limiting the teachings appended hereto.

[0027] Liquid oral compositions comprising cannabinoids

[0028] For the purposes of the present invention, the term "cannabinoid" means a substance capable of activating cannabinoid receptors present in cells. They may be selected from endocannabinoids, phytocannabinoids and synthetic cannabinoids.

[0029] Endocannabinoids are man-made substances that activate cannabinoid receptors. Non-limiting examples of endogenous cannabinoids include anandamide (AEA), 2-arachidonoylglycerol (2-AG), 2-arachidonoylglycerol ether, N-arachidonoylglycerol Acyl dopamine (NADA), virodhamina (OAE) and combinations thereof. Phytocannabinoids are naturally occurring cannabinoids that can be found in plants of the genus Cannabis. Phytocannabinoids can exist as extracts, isolated compounds, or synthetica...

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Abstract

The present invention describes an oral pharmaceutical composition containing cannabinoid(s), an oily liquid solvent and a co-solvent, and a method for preparing and using same for the treatment of neurological disorders, especially refractory epilepsy. The analytical methods used to ensure the authenticity, quality and purity of the active pharmaceutical input and of the formulation produced werevalidated and have defined specifications.

Description

technical field [0001] The present invention describes an oral pharmaceutical composition comprising cannabinoids in an oily liquid carrier and a method for preparing the same. [0002] The present invention can be used in the treatment of neurological disorders, especially intractable epilepsy. [0003] The present invention describes analytical methods and protocols for the quality control of active pharmaceutical ingredients (API) and oral pharmaceutical formulations containing cannabidiol. [0004] The present invention describes safety and efficacy evaluation studies of oral formulations containing cannabidiol. Background technique [0005] Plants of the genus Cannabis (Cannabis sativa, Cannabis ruderalis and Cannabis indica) possess various substances of interest in science and medicine, so-called cannabinoids, such as: Δ9- Tetrahydrocannabinol (D9-THC), Δ8-tetrahydrocannabinol (D8-THC), tetrahydrocannabinolic acid (THC-A), tetrahydrocannabinol (tetrahidrocannabivari...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K47/44A61P25/00A61P25/08A61P25/16A61P25/18A61P25/20
CPCA61K9/08A61P25/00A61P25/04A61P25/16A61P25/22A61P25/18A61P43/00A61P25/08A61K9/0095A61K47/44A61K9/0053A61K31/05A61K47/10
Inventor L·都纳杜齐C·M·都纳杜齐C·G·B·德梅内塞斯L·B·朱尼尔V·J·T·菲尔厚P·M·罗萨J·A·克里帕J·E·C·阿拉A·W·扎尔迪F·S·吉马良斯
Owner PRATI DONADUZZI & CIA
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