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New application of medicine composition

A composition and drug technology, applied in the field of pharmaceutical composition, can solve unforeseen problems

Active Publication Date: 2018-08-17
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the pharmaceutical composition can significantly improve vascular remodeling and inhibit target organ damage caused by high blood pressure, due to the first-pass effect of the drug after oral administration, it is unpredictable which target organs can be reached

Method used

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  • New application of medicine composition
  • New application of medicine composition
  • New application of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 pharmaceutical particle of the present invention

[0028] Take Gastrodia elata 1.2kg, Uncaria 1kg, Lianzixin 0.6kg, Scutellaria baicalensis 0.5kg, 3.3kg in total, grind and mix the weighed medicines, add 10 times the amount of water to soak for 0.5h, decoct in water for 1h, and extract 2 times, filter, combine the filtrates, concentrate under reduced pressure to a thick paste, dry under reduced pressure for 10 hours, and pulverize to obtain that.

Embodiment 2

[0029] The preparation of embodiment 2 medicines of the present invention

[0030] Take Gastrodia elata 10kg, Uncaria 20kg, Lianzixin 5kg, Scutellaria baicalensis 15kg, grind and mix the weighed medicines, add 10 times the amount of water to soak for 0.5h, decoct in water for 1h, extract twice in total, filter, and combine the filtrates, Concentrate under reduced pressure to a thick paste, dry under reduced pressure for 10 hours, and pulverize to obtain the obtained product.

Embodiment 3

[0031] Embodiment 3 preparation of medicine of the present invention

[0032] Take Gastrodia elata 30kg, Uncaria 15kg, Lianzixin 15kg, Scutellaria baicalensis 5kg, grind them, mix the weighed medicines, add 10 times the amount of water to soak for 0.5h, decoct in water for 1h, extract twice in total, filter, and combine the filtrates, Concentrate under reduced pressure to a thick paste, dry under reduced pressure for 10 hours, and pulverize to obtain the obtained product.

[0033] Prove beneficial effect of the present invention by pharmacodynamic test below.

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Abstract

The invention discloses application of a medicine composition in preparing medicine capable of protecting heart, kidney and brain tissue target organ. The medicine composition comprises, by weight, 10-30 parts of rhizoma gastrodiae, 10-20 parts of uncaria, 5-15 parts of lotus plumule and 5-15 parts of radix scutellariae. The medicine composition can lower blood pressure, relieve damage caused to specific target organs like heart, brain and kidney, reduce myocardial and renal interstitial fibrosis area, activate astrocyte and improve structural dysfunction of the target organs like heart, kidney and brain in the process of high blood pressure, and an experimental basis is provided for clinical application.

Description

technical field [0001] The invention relates to a new application of a pharmaceutical composition. Background technique [0002] Hypertension is one of the major diseases that threaten human life worldwide. With the change of people's lifestyle, the morbidity and mortality are increasing year by year. The harm of high blood pressure is that it can cause damage to multiple target organs such as the heart, brain, and kidneys, and systemic lesions, and produce corresponding clinical symptoms and complications, such as myocardial infarction, kidney failure, and cerebral hemorrhage, which will worsen the condition and affect the prognosis. Increased mortality. Therefore, the protection of target organs is a key link in the prevention and treatment of hypertension. The essence of hypertension is the proliferation and hypertrophy of vascular smooth muscle cells and fibroblasts. As a result, the blood vessel wall becomes thicker and less elastic, impeding blood circulation, causi...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61P9/12A61P9/00A61P13/12A61P25/00
CPCA61K36/539A61K36/62A61K36/74A61K36/8988A61P9/00A61P9/12A61P13/12A61P25/00A61K2300/00
Inventor 陈可冀彭军褚剑锋陈友琴林珊蔡巧燕张铃陈达鑫包丽亚
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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