Porous material

A porous material and porous layer technology, applied in the field of porous materials for medical implants, can solve problems such as unsatisfactory bone growth ability and effect, poor tissue fluid flow, and influence on bone tissue regeneration, so as to achieve easy control of process and parameters, Improves hydrophilicity and promotes bone regeneration

Active Publication Date: 2018-08-28
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although people have done a lot of research on porous medical implant materials, their bone growth ability and effect are still not ideal at present. Conventional porous material implants have a single pore structure, and there is poor flow of interstitial fluid, which makes cells difficult to reach. Deep in the implant, uneven internal cells and other problems may even cause some cells to die, resulting in incomplete and uneven bone growth, which affects the regeneration of bone tissue

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0032] The porous material in this embodiment is porous hydroxyapatite, including a material body. The material body is composed of a straight-through channel and a cavity wall around the channel. The cross-section of the straight-through channel is 300 μm×300 μm. There are through small channels inside the wall, and the small channels are also straight-through channels. The equivalent diameter of the small channel section is 30 μm, and all the small channels are connected in the entire material body. The hole with the smaller diameter of the channel is 10 μm in diameter, and the smaller hole is connected with other holes on the wall of the cavity, and also connected with the channel and the small channel. The preparation method is as follows:

[0033] (1) Take 0.4g of polyvinyl alcohol, add 60ml of distilled water, heat to 150°C, completely dissolve the polyvinyl alcohol, and obtain a mixed solution of polyvinyl alcohol and distilled water; powder hydroxyapatite powder with a ...

Embodiment 2

[0041]The porous material in this embodiment is porous tantalum, including a material body, the material body is composed of a straight-through channel and a cavity wall around the channel, wherein the cross-section of the straight-through channel is 420 μm×420 μm, and the channel is connected, inside the cavity wall There are also through small passages, the small passages are also straight-through passages, the equivalent diameter of the small passage section is 50 μm, all the small passages are connected in the entire material body, and there is at least one on the wall of the cavity The hole with a smaller channel diameter has a pore diameter of 25 μm. The smaller hole not only communicates with other holes on the wall of the cavity, but also communicates with the channel and the small channel. The preparation method is as follows:

[0042] (1) Take 0.6g of polyvinyl alcohol, add 40ml of distilled water, heat to 140°C, and completely dissolve the polyvinyl alcohol to obtain...

Embodiment 3

[0051] The porous material in this embodiment is porous titanium, including a material body, the material body is composed of a straight-through channel and a cavity wall around the channel, wherein the cross-section of the straight-through channel is 560 μm×560 μm, and the channel is connected, inside the cavity wall There are also through small channels, the small channels are also straight-through channels, the equivalent diameter of the small channel section is 90 μm, all the small channels are connected in the entire material body, and at least one of the cavity walls is larger than the The hole with the smaller diameter of the channel has a pore diameter of 15 μm-48 μm, and the smaller hole not only communicates with other smaller pores, but also communicates with the channel and the small channel, and its preparation method is as follows:

[0052] (1) Use a tungsten wire with a diameter of 90 μm, soak it in 40% hydrofluoric acid for 30 minutes, then clean it with acetone...

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Abstract

the invention relates to a porous material, wherein the material body comprises a straight through channel and a cavity wall surrounding the channel, the channel is communicated, small straight through channels penetrate through the interior of the cavity wall and are communicated to each other in the material body, and at least one kind of holes with the size of less than the diameter of the channel are arranged on the cavity wall, are communicated to other holes on the cavity wall, and are communicated to the channel and the small channels. The preparation method comprises: weaving a metal mesh by using metal wires according to the structures of the small channels, such that the metal wires on the metal mesh are straight line on the whole metal mesh; and preparing a porous layer on the wires, and corroding out the metal mesh to prepare the porous material. According to the present invention, with the porous material, tissue fluids and cells can conveniently, smoothly and rapidly reach the deep position of the porous metal so as to smoothly reach each part of the cavity wall; the porous material has strong capillary effect, can powerfully absorb and transmit tissue fluids and cells, and can easily achieve the growth and adhesion of cells; and the preparation method can easily ensure the hole structure, the process and the parameters are easy to control, and the process is simple.

Description

technical field [0001] The present invention relates to porous materials, in particular to a porous material for medical implantation. Background technique [0002] With the rapid increase of the social population, the emergence of a large number of means of transportation, the accelerated pace of life, the frequent occurrence of diseases, natural disasters, traffic accidents, sports trauma and work-related injuries, and local wars, etc., have caused a sharp increase in people's accidental injuries. Biomedical implant materials demand has increased substantially. The elastic modulus of solid materials (such as metals, ceramics, etc.) is much higher than that of natural bone. After implantation in the body, it is easy to produce a stress shielding effect, which makes the implant loose and fall off, affecting the stability of the implant. Studies have shown that the structural properties of the material can significantly affect the speed of new bone growth. The porous design ...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/04A61L27/06A61L27/10
CPCA61L27/042A61L27/045A61L27/047A61L27/06A61L27/10A61L27/56A61L2430/02
Inventor叶雷
OwnerCHONGQING RUNZE PHARM CO LTD