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Composition comprising botulinum toxin

A kind of botulinum toxin, composition technology, applied in the field of applying the composition of the present invention, spasticity and/or wrinkles, treatment or prevention of dystonia, can solve problems such as blepharoptosis

Pending Publication Date: 2018-08-28
MERZ PHARMA GMBH & CO KGAA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, injection of an overdose of conventional botulinum toxin preparations in the glabellar wrinkles may cause ptosis

Method used

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  • Composition comprising botulinum toxin
  • Composition comprising botulinum toxin
  • Composition comprising botulinum toxin

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0125] Two subunits of the composition are prepared.

[0126] Subunit 1: A lyophilizate containing 50 units of botulinum neurotoxin type A, 25 mg human serum albumin (HSS) and 1.18 mg sucrose was reconstituted with 1 ml 0.9% saline.

[0127] Subunit 2: Provide a solution containing 1 ml of water, 14 mg of non-cross-linked hyaluronic acid with an average molecular weight of about 3.8 kD, 34 mg of mannitol, 3.0 mg of glycerol, 0.6 mg of phosphate buffer.

[0128] The subunits were mixed such that 1 ml of the resulting aqueous compositions each contained:

[0129]

[0130] Reference example

[0131] The reference composition was obtained by reconstituting a lyophilizate containing 50 units of botulinum neurotoxin type A, 25 mg of human serum albumin (HSS) and 1.18 mg of sucrose with 1 ml of 0.9% saline.

[0132] Thus, the resulting aqueous compositions each contain:

[0133]

[0134] 2. Comparison of efficacy

[0135] 2.1 Each group of 10 mice was injected into the righ...

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Abstract

The present invention concerns a composition comprising (a) botulinum toxin and (b) non-crosslinked hyaluronic acid and its use of the treatment or prevention of dystonia, spasticity and / or wrinkles.Further, the present invention relates to a method for cosmetically smoothing or preventing wrinkles comprising the step of administering the present composition.

Description

technical field [0001] The present invention relates to compositions comprising (a) botulinum toxin and (b) non-crosslinked hyaluronic acid and their use for the treatment or prevention of dystonia, spasticity and / or wrinkles. Furthermore, the present invention relates to a method for cosmetically smoothing or preventing wrinkles comprising the step of applying the composition of the present invention. Background technique [0002] "Botulinum neurotoxin" (BoNT) can be considered an umbrella term for a group of several very similar neurotoxin proteins. The naturally occurring botulinum neurotoxin is produced by the anaerobic and spore-forming bacterium Clostridium botulinum, and rarely by other Clostridium species such as C. butyricum, Clostridium botulinum (C. barati) and Clostridium argentinosus (C. argentinense). There are currently eight different toxin serotypes known as A, B, C 1 、C 2 , D, E, F and G types. Some of these types, such as types A, B, E and F, are toxi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61K47/36A61Q19/08
CPCA61Q19/08A61K47/36A61K8/64A61K8/735A61K2800/91A61K9/0019A61K9/08A61K38/4893A61P21/00Y02A50/30A61P17/00A61K9/19A61K31/728A61K38/16A61K38/48A61Q19/00
Inventor K·芬克H·泰勒H·罗斯P·博德克
Owner MERZ PHARMA GMBH & CO KGAA