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Injectable self-curing artificial bone repair material and preparation method thereof

A technology for repairing materials and artificial bones, which can be used in pharmaceutical formulations, prostheses, and drug delivery. It can solve the problems of calcium phosphate materials such as long degradation time, inability to degrade, and secondary injury to patients, so as to facilitate inspection and maintain good health. Effect of biocompatibility, degradation rate matching

Active Publication Date: 2020-11-06
BEIJING ALLGENS MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventor found in the research that the degradation time of calcium phosphate materials is long or cannot be degraded
When calcium phosphate bone repair materials are used for treatment, the bone repair materials of some patients need to be removed by surgery, which can easily cause secondary damage to patients

Method used

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  • Injectable self-curing artificial bone repair material and preparation method thereof
  • Injectable self-curing artificial bone repair material and preparation method thereof
  • Injectable self-curing artificial bone repair material and preparation method thereof

Examples

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preparation example Construction

[0053] A preparation method for an injectable self-curing artificial bone repair material, the preparation method comprising the steps of:

[0054] (1) Preparation of biphasic calcium phosphate porous particles: the preparation components include the first calcium salt, polyvinyl alcohol and PMMA microspheres, the mass ratio is (0.1~0.5): 3:2, and the first calcium salt is composed of hydroxyl phosphorus Limestone and β-calcium phosphate are composed according to the mass ratio of 5:1~1:3;

[0055] Preparation methods include:

[0056] (a) preparing a polyvinyl alcohol solution with a concentration of 0.2 to 0.5 g / mL;

[0057] (b) preparing a biphasic phosphate suspension; adding hydroxyapatite and β-calcium phosphate to the PBS solution to form a suspension;

[0058] (c) adding the polyvinyl alcohol solution to the biphasic phosphate suspension, stirring for 0.5 to 1 hour, then adding PMMA microspheres, and stirring for 0.5 to 1 hour to obtain a sintered base liquid;

[00...

Embodiment 1

[0084] S1, preparation of α-calcium sulfate hemihydrate powder by hydrothermal method

[0085] CaSO 4 2H 2 O is added to the reactor, and the CaSO 4 2H 2 O quality 0.25% sodium citrate and aluminum sulfate, add in the reaction kettle, then add CaSO 4 2H 2 O 5.67 times the quality of deionized water, closed the reaction kettle, stirred, the temperature was 120 ° C, and reacted for 6 hours; The temperature of the medium filtrate and the washing solution is above 90°C; put the drained filter cake in a drying oven at 100°C and dry for 12 hours to obtain α-calcium sulfate hemihydrate; grind it with a mortar and sieve it through a 100-mesh sieve to obtain α-calcium sulfate hemihydrate powder with uniform particle size.

[0086] S2. Preparation of biphasic calcium phosphate porous particles

[0087] The preparation component comprises the first calcium salt, polyvinyl alcohol and PMMA microspheres (by the PMMA microspheres of 100 microns in particle diameter and the PMMA micro...

Embodiment 2

[0111] Preparation method is basically the same as Example 1, except that:

[0112] In S2:

[0113] PMMA microspheres with a particle size of 100 microns were used as pore-forming agents.

[0114] In S3:

[0115] The concentration of the collagen acid solution is 5mg / mL, and the concentration of the suspension is 20wt%;

[0116] Add 0.05 mol of calcium ions to each gram of collagen, and the molar ratio of phosphate ions to calcium ions is Ca / P=1.8;

[0117] The content of mineralized collagen in the obtained mineralized collagen porous calcium phosphate composite material is 10%.

[0118] In S4:

[0119] The mineralized collagen porous calcium phosphate composite material and α-calcium sulfate hemihydrate powder were mixed according to the mass ratio of 3:7, the setting time was 20 minutes, and the degradation time was 1 year.

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Abstract

The invention relates to an injectable self-curing artificial bone repair material and a preparation method thereof. The preparation method comprises the following steps: preparation of two-phase calcium phosphate porous particles, preparation of mineralized collagen porous calcium phosphate composite material and mixing with calcium sulfate hemihydrate. The prepared artificial bone repair material has the following characteristics that: (a) the mineralized collagen is uniformly distributed on the surface and the pores of the two-phase calcium phosphate porous particles, so that the mineralized collagen is uniformly combined with the porous calcium phosphate, thereby having better biocompatibility; (b) the material has a porous structure, not only is favorable for the growth of the bone tissue and the creeping substitution, but also has certain supporting strength; (c) the material can be used as a carrier for growth factors and various antibiotics to carry out anti-inflammatory treatment; (d) the material can be developed under X-ray, which facilitates inspection; (e) the material is degradable, which avoids secondary pain resulting from taking out, and the rate of degradation maybe matched with the new bone growth rate; (f) the material can be injected in situ and has excellent self-curing properties.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an injectable self-curing artificial bone repair material and a preparation method thereof. Background technique [0002] Bone tissue is the largest organ in the human body and is also the most likely to cause defects. Every year, millions of patients with bone tissue defects need surgical treatment. The loss of bone organs or tissue defects caused by osteoporosis, trauma, tumor, and infection has become one of the problems that plague the healthy life of human beings. Clinically, bone graft repair and reconstruction surgery is usually performed to restore the shape and function of the defect site. Bone graft has become the graft with the largest demand after blood transfusion, and there is a trend of increasing year by year. [0003] At present, implant materials for the treatment of bone defects can be roughly divided into autologous bone, allogeneic bone, xenogra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58A61L27/50A61L27/54A61L27/56A61L27/46A61L27/24
CPCA61L27/24A61L27/46A61L27/50A61L27/54A61L27/56A61L27/58A61L2400/06A61L2430/02C08L29/04C08L33/02
Inventor 何志敏宋天喜连小洁仇志烨朱金亮胡艳丽崔云崔菡崔福斋
Owner BEIJING ALLGENS MEDICAL SCI & TECH
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