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Paeonol oil-in-water nanoemulsion of bitter neroli oil and preparation method thereof

A kind of neroli oil, oil-in-water technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations and other directions, can solve the problem that active ingredients are difficult to reach, and achieve the advantages of skin absorption, good stability and particle size. uniform effect

Active Publication Date: 2021-10-22
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Melanocytes are located between the epidermis and dermis. Traditional anti-freckle lotions cannot quickly penetrate the skin barrier, making it difficult for active ingredients to reach melanocytes

Method used

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  • Paeonol oil-in-water nanoemulsion of bitter neroli oil and preparation method thereof
  • Paeonol oil-in-water nanoemulsion of bitter neroli oil and preparation method thereof
  • Paeonol oil-in-water nanoemulsion of bitter neroli oil and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Step 1: Add 1ml of bitter neroli oil into the container, stir and heat to 30-50°C, add 0.05g of paeonol according to the mass fraction, after stirring evenly to dissolve, add 14ml of octyldodecanol, stir well Finally, add 3g Tween-80; after stirring and dissolving evenly, phase A is obtained.

[0037] Step 2: Add deionized water into the container, heat to 45-50°C, add 0.1g potassium sorbate and 3g glycerin in sequence according to the mass fraction, and stir to dissolve evenly into phase B.

[0038] Step 3: Slowly add phase B to phase A and stir to obtain oil-in-water nanoemulsion.

[0039] The average particle size of the nanoemulsion prepared in this example with the effect of removing freckles and moisturizing is measured by a laser particle size potential analysis tester, and contains 0.05% paeonol.

Embodiment 2

[0041] Step 1: Add 1ml of bitter neroli oil into the container, stir and heat to 30-50°C, add 0.05g of paeonol according to the mass fraction, after stirring evenly to dissolve, add 15ml of octyldodecanol, stir well Finally, add 4g Tween-80; after stirring and dissolving evenly, phase A is obtained.

[0042] Step 2: Add deionized water into the container, heat to 45-50°C, add 0.1g potassium sorbate and 3g glycerin in sequence according to the mass fraction, and stir to dissolve evenly into phase B.

[0043] Step 3: Slowly add phase B to phase A and stir to obtain oil-in-water nanoemulsion. .

[0044] The average particle size of the nanoemulsion prepared in this example with the effect of removing freckles and moisturizing is measured by a laser particle size potential analysis tester, and it contains 0.05% paeonol.

Embodiment 3

[0046] Step 1: Add 1ml of bitter neroli oil into the container, stir and heat to 30-50°C, add 0.05g of paeonol according to the mass fraction, after stirring evenly to dissolve, add 13ml of octyldodecanol, stir well Finally, add 3g Tween-80; after stirring and dissolving evenly, phase A is obtained.

[0047] Step 2: Add deionized water into the container, heat to 45-50°C, add 0.1g potassium sorbate and 3g glycerin in sequence according to the mass fraction, and stir to dissolve evenly into phase B.

[0048]Step 3: Slowly add phase B to phase A and stir to obtain oil-in-water nanoemulsion.

[0049] The average particle size of the nanoemulsion prepared in this example with the effect of removing freckles and moisturizing is measured by a laser particle size potential analysis tester, and it contains 0.05% paeonol.

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Abstract

The invention relates to an oil-in-water nanoemulsion of neroli oil paeonol and a preparation method thereof, belonging to the field of cosmetic dosage forms. It is characterized in that: the present invention consists of 0.05%-0.1% paeonol, 1%-3.0% neroli oil, 10%-20% octyldodecanol, 4-11% emulsifier and co-emulsifier, 0.05 % sodium ascorbyl phosphate, 0.1% potassium sorbate, and the balance is composed of deionized water. The advantage is to overcome the low solubility of paeonol, improve the transdermal absorption of paeonol, and improve the bioavailability. It is combined with bitter neroli oil and ascorbic acid Sodium Phosphate and Glycerin for anti-freckle and moisturizing effect.

Description

technical field [0001] The invention belongs to the field of cosmetics, in particular to a preparation method of paeonol oil-in-water nanoemulsion of neroli oil. Background technique [0002] Cortex Moutan is the dry root bark of tree peony of the family Ranunculaceae. Paeonol is the main active ingredient of Cortex Moutan. Paeonol is an antioxidant that can remove oxygen free radicals in cells, and tyrosinase catalyzes the oxidation of substrates to generate melanin. The process requires the participation of oxygen molecules, which blocks the production chain of melanin. On the other hand, paeonol is a mixed inhibitor of tyrosinase, which acts on the enzyme and inhibits its activity, making the skin whiter. It can be seen that paeonol has a good therapeutic effect on pigmentation diseases such as spots. Intense ultraviolet rays, coupled with severely polluted air, lead to various problems on people's skin, among which problems such as dark complexion, pigmentation, and dr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/06A61K8/92A61K8/67A61K8/35A61K8/34A61Q19/02A61Q19/00
CPCA61K8/062A61K8/342A61K8/345A61K8/35A61K8/676A61K8/922A61K2800/21A61K2800/592A61K2800/782A61Q19/00A61Q19/02
Inventor 金向群赵倩倩禹珊珊
Owner JILIN UNIV
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