A kind of compound sulfachloropyridazine sodium dry suspension and preparation method thereof

A technology of dry suspension and sodium chlorpyridazine, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., to achieve high safety, simple operation, and good overall stability Effect

Active Publication Date: 2020-05-15
ZHEJIANG WANFANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the particle size decreases until the Brownian motion is gradually obvious until it offsets the particle drop and maintains a stable state, of course, ordinary dry suspension products cannot achieve this effect

Method used

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  • A kind of compound sulfachloropyridazine sodium dry suspension and preparation method thereof
  • A kind of compound sulfachloropyridazine sodium dry suspension and preparation method thereof
  • A kind of compound sulfachloropyridazine sodium dry suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A compound sulfachloropyridazine sodium dry suspension, containing per 100kg: sulfachlordahydrogen sodium 62.5kg, trimethoprim 12.5kg, xanthan gum 0.03kg, sodium lauryl sulfate 0.6kg, anhydrous glucose 24.37 kg.

[0028] A preparation method of compound sulfachloropyridazine sodium dry suspension is:

[0029] (1) take each raw material by required parts by weight, for subsequent use;

[0030] (2) Mix trimethoprim and sodium lauryl sulfate evenly, add 16kg of water, stir evenly, and grind for 30 minutes in a vertical sander to form a suspension of particles, and the particle size is controlled at 5-10 μm;

[0031] (3) Add xanthan gum to the microparticle suspension to shear evenly, and then pass through a high-pressure homogenizer to form a microparticle emulsion;

[0032] (4) The filling auxiliary material anhydrous glucose is passed through a 120-mesh sieve for subsequent use;

[0033] (5) In step (4), anhydrous glucose and sulfachloropyridazine sodium raw materials...

Embodiment 2

[0035] A compound sulfachloropyridazine sodium dry suspension, containing in every 100kg: sulfachlordahydrogen sodium 62.5kg, trimethoprim 12.5kg, hydroxypropyl methylcellulose 0.04kg, N-hexadecyl- N-ethylmorpholino sodium ethyl sulfate 0.8kg, maltodextrin 24.16kg.

[0036] A preparation method of compound sulfachloropyridazine sodium dry suspension is:

[0037] (1) take each raw material by required parts by weight, for subsequent use;

[0038] (2) Mix trimethoprim and oleic acid formazan evenly, add 16kg of water, stir evenly, and grind for 30 minutes in a vertical sander to form a particle suspension, and the particle size is controlled at 5-10 μm;

[0039] (3) Add hydroxypropyl methylcellulose to the microparticle suspension to shear evenly, and then pass through a high-pressure homogenizer to form a microparticle emulsion;

[0040] (4) The filling auxiliary material maltodextrin is passed through a 120-mesh sieve for later use;

[0041] (5) In the step (4), the maltode...

Embodiment 3

[0043] A compound sulfachloropyridazine sodium dry suspension, containing in every 100kg: sulfachlordahydrogen sodium 65kg, trimethoprim 13kg, xanthan gum and hydroxypropyl methylcellulose each 0.02kg, sodium lauryl sulfate And N-hexadecyl-N-ethylmorpholinyl sodium ethyl sulfate 0.3kg each, maltodextrin 21.36kg.

[0044] A preparation method of compound sulfachloropyridazine sodium dry suspension is:

[0045] (1) take each raw material by required parts by weight, for subsequent use;

[0046] (2) Mix trimethoprim with sodium lauryl sulfate and N-hexadecyl-N-ethylmorpholinyl ethyl sulfate, add 16kg of water, stir well, grind in a vertical sander for 30min, It is a microparticle suspension, and the particle size is controlled at 5-10 μm;

[0047] (3) Add xanthan gum and hydroxypropyl methylcellulose to the microparticle suspension to shear evenly, and then pass through a high-pressure homogenizer to form a microparticle emulsion;

[0048] (4) The filling auxiliary material ma...

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Abstract

The invention discloses a compound sulfachloropyridazine sodium dry suspension and preparation method thereof, and belongs to the technical field of veterinary drugs. Each 100 kg of the dry suspensioncontains: 60-70 kg of sulfachloropyridazine sodium, 10-15 kg of trimethoprim, 0.02-0.05 kg of a suspending aid, 0.6-0.8 kg of a surfactant, and 14.15-29.38 kg of a filling additive. The high-efficiency suspending aid used in the invention is one or a combination of xanthan gum and hydroxypropyl methyl cellulose; the surfactant is one or a combination of sodium lauryl sulfate and N-cetyl-N-ethyl morpholinium ethosulfate; and the filling additive is one ingredientof maltodextrin, anhydrous glucose and water-soluble starch or a combination of two ingredients of maltodextrin, anhydrous glucose and water-soluble starch. The compound sulfachloropyridazine sodium dry suspension has good suspension stability, and the prepared suspension can be uniform with no layers for a long time. In clinical use of mixing or drinking, the dry suspension is uniform in administration, has good synchronous absorption effect, has less drug residue, has short withdrawal time, is convenient to use, and can helpreduce culture cost to the maximum.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to a compound sulfachloropyridazine sodium dry suspension and a preparation method thereof. Background technique [0002] The raw material properties of sulfachlordazine sodium are odorless light yellow crystalline powder, easily soluble in water, and its chemical name is N-(6-chloro-pyridazinyl)-4-aminobenzenesulfonamide sodium salt, which is the most important sulfonamide one of the drugs. It has a good effect on the infection of Escherichia coli, Salmonella and Pasteurella in livestock and poultry, as well as the protozoan Toxoplasma and other coccidia. Studies have shown that trimethoprim has a significant synergistic effect on sulfachlorperazine sodium, and is the most commonly used synergist in sulfa drugs, with the characteristics of broad spectrum, high efficiency and low toxicity. Therefore, the compound preparation of sulfachlordazine sodium and trimethoprim i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K31/505A61K9/14A61K47/38A61K47/36A61K47/20A61P31/04A61P31/00
CPCA61K9/146A61K31/505A61K31/635A61K47/20A61K47/36A61K47/38A61K2300/00
Inventor 杨彩梅杨彪倪志兵刘金松
Owner ZHEJIANG WANFANG BIO TECH CO LTD
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