Method for measuring contents of active substances and chemical components of traditional Chinese medicines

A chemical composition and technology of traditional Chinese medicine, applied in the medical field, can solve the problems of inapplicable quality evaluation of Chinese patent medicines, lack of theoretical basis and theoretical guidance in terms of the overall effect of herbal preparations and the correlation of drug effects

Inactive Publication Date: 2018-10-09
JIANGNAN UNIV
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Problems solved by technology

However, the research on fingerprints of traditional Chinese medicine is mainly aimed at the extraction of single medicinal materials, and lacks theoretical basis and corresponding the

Method used

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  • Method for measuring contents of active substances and chemical components of traditional Chinese medicines
  • Method for measuring contents of active substances and chemical components of traditional Chinese medicines
  • Method for measuring contents of active substances and chemical components of traditional Chinese medicines

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Embodiment Construction

[0044] figure 1 is a flowchart of the method of the present invention. Such as figure 1 As shown, the steps of this method are:

[0045] Step a, preparing a calibration sample set and a prediction sample set. The traditional Chinese medicine materials are pretreated to obtain decoctions, and the decoctions are made into solutions of different concentrations, which are used as calibration sample sets and prediction sample sets.

[0046] The pretreatment method is as follows: first soak the traditional Chinese medicine in water, and then boil it with fire. Furthermore, the process of boiling with fire is to first boil with strong fire and then boil with slow fire.

[0047] Step b, measuring the three-dimensional fluorescence spectra of the calibration sample set and the prediction sample set, and obtaining the three-dimensional fluorescence spectrum graphs of the calibration sample set and the prediction sample set.

[0048] Step c, data preprocessing. Using wavelet transf...

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Abstract

The invention discloses a method for measuring contents of active substances and chemical components of traditional Chinese medicines. The method comprises the following steps: step a, preparing a correcting sample set and a prediction sample set; step b, carrying out three-dimensional fluorescence spectrum measurement on the correcting sample set and the prediction sample set to obtain three-dimensional fluorescence spectrum charts of the correcting sample set and the prediction sample set; step C, preprocessing of data: carrying out wavelet noise reduction processing on spectroscopic data bywavelet transform; and then deducting three-dimensional spectral signals of background from three-dimensional spectral signals of traditional Chinese medicinal materials; and step d, establishment ofa correcting model: analyzing the correcting sample set by using a parallel factor algorithm at first; and then establishing a quantitative regression model, and predicting the concentration of the prediction sample set. The active substances and the chemical components of traditional Chinese medicinal materials and the contents of the active substances and the chemical components can be identified rapidly, sensitively and accurately, and the method is applied to monitoring and evaluating of quality of the traditional Chinese medicinal materials.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for determining the content of effective substances and chemical components of traditional Chinese medicines by using three-dimensional fluorescence spectrum combined with PARAFAC algorithm. Background technique [0002] In recent years, the "safety hazards" of various traditional Chinese medicines (including traditional Chinese medicinal materials and proprietary Chinese medicines) have been continuously exposed, arousing consumers' concerns, and many overseas countries have also continued to "warn" traditional Chinese medicines, making the overseas markets of traditional Chinese medicines produced in mainland China Sustained setbacks, the entire Chinese medicine industry is facing a huge crisis of confidence. The safety problems of traditional Chinese medicine mainly come from two aspects: first, adulteration, that is, replacing high-priced medicinal materials with cheap medici...

Claims

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Application Information

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IPC IPC(8): G01N21/64
CPCG01N21/6402
Inventor 杨航朱纯李晓琳马海颖孙云玲王介
Owner JIANGNAN UNIV
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