Method for measuring contents of active substances and chemical components of traditional Chinese medicines

Abstract

The invention discloses a method for measuring contents of active substances and chemical components of traditional Chinese medicines. The method comprises the following steps: step a, preparing a correcting sample set and a prediction sample set; step b, carrying out three-dimensional fluorescence spectrum measurement on the correcting sample set and the prediction sample set to obtain three-dimensional fluorescence spectrum charts of the correcting sample set and the prediction sample set; step C, preprocessing of data: carrying out wavelet noise reduction processing on spectroscopic data bywavelet transform; and then deducting three-dimensional spectral signals of background from three-dimensional spectral signals of traditional Chinese medicinal materials; and step d, establishment ofa correcting model: analyzing the correcting sample set by using a parallel factor algorithm at first; and then establishing a quantitative regression model, and predicting the concentration of the prediction sample set. The active substances and the chemical components of traditional Chinese medicinal materials and the contents of the active substances and the chemical components can be identified rapidly, sensitively and accurately, and the method is applied to monitoring and evaluating of quality of the traditional Chinese medicinal materials.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for determining the content of effective substances and chemical components of traditional Chinese medicines by using three-dimensional fluorescence spectrum combined with PARAFAC algorithm. Background technique [0002] In recent years, the "safety hazards" of various traditional Chinese medicines (including traditional Chinese medicinal materials and proprietary Chinese medicines) have been continuously exposed, arousing consumers' concerns, and many overseas countries have also continued to "warn" traditional Chinese medicines, making the overseas markets of traditional Chinese medicines produced in mainland China Sustained setbacks, the entire Chinese medicine industry is facing a huge crisis of confidence. The safety problems of traditional Chinese medicine mainly come from two aspects: first, adulteration, that is, replacing high-priced medicinal materials with cheap medici...

AI Technical Summary

Problems solved by technology

However, the research on fingerprints of traditional Chinese medicine is mainly aimed at the extraction of single medicinal materials, and lacks theoretical basis and corresponding theoretical guidance in terms of the overall effect of herbal preparations and the correlation of drug effects, and is not suitable for the quality evaluation of Chinese patent medicines.

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