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A kind of dopamine-grafted sulfonated sodium alginate double-crosslinked microsphere and its preparation method and use

A technology of sodium alginate and dopamine, applied in chemical instruments and methods, inorganic chemistry, other chemical processes, etc., can solve the problems of changing platelet and fibrinolytic state, thrombocytopenia, bleeding tendency, etc., to achieve mechanical strength improvement, biological Good compatibility and enhanced stability

Active Publication Date: 2020-02-18
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the anticoagulant effect of heparin is obvious, it also has some disadvantages when used, mainly including: expensive, easy to inactivate as a biologically active substance, cause thrombocytopenia, aggravate anemia, change the state of platelet and fibrinolysis, and have bleeding tendency , allergic reactions, combined with calcium to cause osteoporosis, etc. (Stanley, F.E.et al., Analytical and Bioanalytical Chemistry, 2011,399:701-706)

Method used

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  • A kind of dopamine-grafted sulfonated sodium alginate double-crosslinked microsphere and its preparation method and use
  • A kind of dopamine-grafted sulfonated sodium alginate double-crosslinked microsphere and its preparation method and use

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preparation example Construction

[0024] The preparation method of dopamine-grafted sulfonated sodium alginate double-crosslinked microspheres comprises the following steps:

[0025] 1) Preparation of dopamine-grafted sulfonated sodium alginate

[0026] Add 4-12g of concentrated sulfuric acid into 100mL of DMF and cool to room temperature, add 3-7g of sodium alginate and fully dissolve it. Add 9~21g of DCC, stir and react at room temperature for 2~4h. Use a glass sand funnel to filter and remove the precipitate, add three times the amount of dichloromethane to the filtrate for phase separation and precipitation, let stand to separate layers, and collect the lower layer of precipitate by centrifugation. Sodium hydroxide solution (0.5mol / L) was used to dissolve the resulting precipitate and then filtered with a glass sand funnel to remove the DCC-urea precipitate. Dialyze the filtrate with a dialysis bag and freeze-dry to obtain the product sulfonated sodium alginate. Then dopamine is grafted onto the molecul...

Embodiment 1

[0034] Add 6g of concentrated sulfuric acid into 100mL of DMF solution and cool to room temperature, add 7g of SA with a viscosity of 200mPa·s and fully dissolve it. 21 g of DCC was added and stirred and reacted at room temperature for 4 h. Use a glass sand funnel to filter and remove the precipitate, add three times the amount of dichloromethane to the filtrate for phase separation and precipitation, let stand to separate layers, and collect the lower layer of precipitate by centrifugation. Sodium hydroxide solution (0.5mol / L) was used to dissolve the resulting precipitate and then filtered with a glass sand funnel to remove the DCC-urea precipitate. The filtrate was dialyzed with a dialysis bag and freeze-dried to obtain the intermediate product SAS. Then 1 g of SAS was dissolved in MES buffer, 0.3 g of EDC and 0.1 g of NHS were added. Afterwards, 0.7 g of DA·HCl was added, and the reaction was performed under magnetic stirring for 24 h at room temperature under the protec...

Embodiment 2

[0038] Add 12 g of concentrated sulfuric acid into 100 mL of DMF solution and cool to room temperature, add 3 g of SA with a viscosity of 400 mPa·s and fully dissolve it. Add 9g of DCC and stir and react at room temperature for 4h. Use a glass sand funnel to filter and remove the precipitate, add three times the amount of dichloromethane to the filtrate for phase separation and precipitation, let stand to separate layers, and collect the lower layer of precipitate by centrifugation. Sodium hydroxide solution (0.5mol / L) was used to dissolve the resulting precipitate and then filtered with a glass sand funnel to remove the DCC-urea precipitate. The filtrate was dialyzed with a dialysis bag and freeze-dried to obtain the intermediate product SAS. Then 2 g of SAS was dissolved in MES buffer, 0.5 g of EDC and 0.2 g of NHS were added. Afterwards, 1 g of DA·HCl was added, and the reaction was performed under magnetic stirring at room temperature for 24 h under the protection of nit...

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Abstract

The invention relates to dopamine grafted sulfonated sodium alginate bi-crosslinked microspheres as well as a preparation method and an application thereof. The dopamine grafted sulfonated sodium alginate bi-crosslinked microspheres have low cost and anticoagulation effect, so that an anticoagulant is not needed to be added in a use process. The invention further discloses the preparation method and the application of the dopamine grafted sulfonated sodium alginate bi-crosslinked microspheres. The microspheres can be widely applied to the field of blood contact treatment.

Description

technical field [0001] The invention relates to the field of functional polymer materials, in particular to a dopamine-grafted sulfonated sodium alginate double-crosslinked microsphere, a preparation method and application thereof. Background technique [0002] The blood system circulates throughout the body, transports nutrients to various functional tissues, brings the metabolic waste of the body to the liver, kidney and other organs for metabolism and excretion, and maintains the balance of body fluids. Once the liver, kidney, immune system, etc. malfunction or lose, it will lead to the accumulation of different endogenous chemical components in the blood, which will cause a variety of diseases, such as liver failure, uremia, kidney failure, hyperlipidemia and certain diseases. some immune diseases. Hemoperfusion is a process in which blood removes endogenous or exogenous toxins in the patient's blood through extracorporeal circulation through the adsorbent with special ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/24B01J20/28B01J20/30C08B37/00A61M1/36
CPCA61M1/3679A61M2205/02B01J20/24B01J20/28004B01J20/28011B01J20/28019B01J20/28059C08B37/0084
Inventor 赵长生何超赵伟锋周密施振强纪海锋钱一晖
Owner SICHUAN UNIV
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