A kind of dihydromyricetin water-soluble nano-suspension agent and its preparation method and application

A technology of dihydromyricetin and nano-suspension, which can be used in pharmaceutical formulations, organic active ingredients, medical preparations containing active ingredients, etc., can solve the problems of environmental pollution, high energy consumption, poor solubility of dihydromyricetin, etc.

Active Publication Date: 2021-07-06
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of this, the present invention provides a dihydromyricetin water-soluble nano-suspension agent and its preparation method and application, which are used to solve the problem of poor solubility of dihydromyricetin in water and the need to use the nano-suspension agent during preparation. Contaminated organic solvents, high energy consumption in the preparation process, etc.

Method used

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preparation example Construction

[0027] A preparation method of dihydromyricetin water-soluble nano-suspension, comprising the following steps:

[0028] a) after the oil phase dissolved with dihydromyricetin and the aqueous solution dissolved with emulsifier are uniformly mixed and emulsified, homogenized under high pressure to obtain an O / W nanoemulsion;

[0029] b) drying the O / W nanoemulsion to obtain dihydromyricetin nanoparticles;

[0030] c) mixing and dispersing dihydromyricetin nanoparticles with water to obtain a dihydromyricetin water-soluble nano-suspension.

[0031] On the premise of not changing the chemical structure of dihydromyricetin, the preparation method of the present invention obtains O / W through mechanical forces such as high-speed, high-pressure and high-frequency impact, collision, shearing, grinding, vibration and dispersion generated by high-pressure homogeneity. Dihydromyricetin nanoparticles obtained after O / W type nanoemulsions are dried are mixed with water so that dihydromyric...

Embodiment 1

[0061] (1) Use Capmul MCM C8 as an organic solvent, and configure an oil phase with a dihydromyricetin content of 5% (W / V); select Tween-20 as an emulsifier, and configure an emulsifier concentration of 0.5% (W / V) aqueous solution to form the aqueous phase. While stirring at a rotating speed of 100rpm, slowly pour the oil phase into the water phase, the volume ratio of the oil phase and the water phase is 1:9, and then continue to stir at a rotating speed of 800rpm for 30min, and mix well. The resulting mixed solution was stirred and emulsified at a speed of 8000 rpm for 10 minutes, and then subjected to 12 high-pressure homogenizations at a pressure of 800 bar. The time for each high-pressure homogenization was 5 minutes to obtain an O / W nanoemulsion. In the O / W type nanoemulsion, The particle size of dihydromyricetin is 50nm-100nm.

[0062] (2) freeze-drying the O / W nanoemulsion at -40°C for 48 hours to obtain dihydromyricetin nanoparticles;

[0063] (3) Mix dihydromyricet...

Embodiment 2

[0065] (1) Use CAPTEX355 as an organic solvent, configure an oil phase with a dihydromyricetin content of 8% (W / V); choose Span-80 as an emulsifier, and configure an aqueous solution with an emulsifier concentration of 0.5% (W / V) , made into an aqueous phase. While stirring at a rotating speed of 150rpm, slowly pour the oil phase into the water phase, the volume ratio of the oil phase and the water phase is 2:8, and then continue to stir at a rotating speed of 900rpm for 20min, and mix well. The resulting mixed solution was stirred and emulsified at a speed of 10,000 rpm for 8 minutes, and then subjected to 10 high-pressure homogenizations at a pressure of 900 bar. The time for each high-pressure homogenization was 8 minutes to obtain an O / W nanoemulsion. In the O / W type nanoemulsion, The particle size of dihydromyricetin is 50nm-100nm.

[0066] (2) Freeze-drying the O / W nanoemulsion at -50°C for 36 hours to obtain dihydromyricetin nanoparticles;

[0067] (3) Dihydromyriceti...

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Abstract

The invention belongs to the technical field of preparations, and in particular relates to a dihydromyricetin water-soluble nano-suspension agent and its preparation method and application. The invention provides a preparation method of dihydromyricetin water-soluble nano-suspension, comprising the following steps: a) mixing the oil phase dissolved in dihydromyricetin and the aqueous solution dissolved in emulsifier uniformly and emulsified, and carrying out high-pressure homogeneous to obtain O / W type nanoemulsion; b) drying the O / W type nanoemulsion to obtain dihydromyricetin nanoparticles; c) mixing the dihydromyricetin nanoparticles with water to disperse , to obtain dihydromyricetin water-soluble nano-suspension. The preparation method of the present invention obtains O / W type nano-emulsion through high-pressure homogenization, and then dries to obtain dihydromyricetin nanoparticles, and dihydromyricetin nanoparticles are mixed with water to prepare dihydromyricetin water-soluble nano-suspension agent, which improves the Improve the solubility of dihydromyricetin in water, expand the application of dihydromyricetin in food and pharmaceutical industry.

Description

technical field [0001] The invention belongs to the technical field of preparations, and in particular relates to a dihydromyricetin water-soluble nano-suspension agent and its preparation method and application. Background technique [0002] Dihydromyricetin, also known as snake grape element, Fujian tea element, beirasuin, etc., belongs to dihydroflavonol compounds and is the main active ingredient of vine tea, a plant of the genus Snake Grape in the grape family. Dihydromyricetin has a variety of biological activities, good safety, but poor stability and low solubility in water. At 25°C, the solubility of dihydromyricetin in water is 0.2mg / mL. When dihydromyricetin is ingested into the human body, fat-soluble dihydromyricetin has poor solubility in water, the main component of the human body, making its bioavailability low, accompanied by toxic and side effects, which limits its use in medicines, food and Application in cosmetics. [0003] In order to improve the water...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K47/44A61K31/352A23L33/00A23L29/10A23L29/00
CPCA61K9/10A61K31/352A61K47/44A23L29/00A23L29/10A23L33/00
Inventor 刘丹毛贻琴吴伟宇丁利君
Owner GUANGDONG UNIV OF TECH
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