Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Liver protection intestinal micro-ecological modulator based on gut-liver axis and preparation method of modulator

A technology of intestinal microecology and regulator, applied in the biological field, can solve the problems of low bioavailability, low survival rate of bacterial strains, long administration cycle, etc., and achieve the effect of promoting proliferation, promoting intestinal microecological regulation, and reducing damage Effect

Active Publication Date: 2018-10-30
NINGBO YUFANGTANG BIOTECH
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, among the many products in the market, almost all of them treat the two differently: Hugan Tablets, Bifendate, Compound Yiganling, etc. are often used to treat various liver diseases, so as to achieve the purpose of nourishing and protecting the liver. However, there are problems such as slow onset of action, long taking cycle, and low bioavailability, and may even cause adverse reactions such as nausea, vomiting, dermatitis, and rashes; probiotics, prebiotics, or synbiotics are often used to regulate the intestinal microecology. Quasi-intestinal regulators, especially regulators containing probiotics, often have problems such as single and unstable strains, difficulty in preservation, low survival rate of strains, and low colonization rate, and for many people with liver diseases, often appear The phenomenon of low cure rate and easy recurrence

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Liver protection intestinal micro-ecological modulator based on gut-liver axis and preparation method of modulator
  • Liver protection intestinal micro-ecological modulator based on gut-liver axis and preparation method of modulator
  • Liver protection intestinal micro-ecological modulator based on gut-liver axis and preparation method of modulator

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] By weight, the liver-gut axis-based liver-protecting intestinal microecological regulator of the present embodiment is prepared with the following raw materials: 150 parts of Echinochloa crusgalli, 130 parts of Snake Snake grape leaves, 200 parts of raspberries, Portulaca oleracea 150 parts, 120 parts of Polygonatum, 60 parts of Cistanche, 8 parts of yeast β-glucan, 15 parts of oligofructose, 20 parts of soybean oligosaccharide.

[0039] The preparation method of the liver-gut axis-based intestinal microecological regulator is as follows:

[0040] (1) Separately preparing extracts of Euphorbia serrata, extracts of Snake dentata grape leaves, and extracts of raspberries;

[0041] After pulverizing, the 10 mesh sieve of Echinochloa sinensis / Snake Snake grape leaves / raspberry was added to the extraction tank, and 10 times the amount of 30% ethanol was added as the extraction solvent, and the extraction was carried out at room temperature for 10 seconds; the flash extractor and va...

Embodiment 2

[0046] By weight, the liver-gut axis-based liver-protecting intestinal micro-ecological regulator of this embodiment is prepared with the following raw materials: 180 parts of Dichrysanthemum indicum, 150 parts of Snaketooth grape leaves, 220 parts of raspberry, Portulaca oleracea 180 parts, 140 parts of Polygonatum, 80 parts of Cistanche, 13 parts of yeast β-glucan, 20 parts of fructooligosaccharides, 40 parts of soybean oligosaccharides.

[0047] The preparation method of the liver-gut axis-based intestinal microecological regulator is as follows:

[0048] (1) Separately preparing extracts of Euphorbia serrata, extracts of Snake dentata grape leaves, and extracts of raspberries;

[0049] After crushing the 24 mesh sieve, the green grass or Snake dentata grape leaves or raspberries are added to the extraction tank, and 15 times the amount of 40% ethanol is added as the extraction solvent, and the extraction is carried out at room temperature for 40s; the flash extractor and vacuum a...

Embodiment 3

[0054] By weight, the liver-gut axis-based liver-protecting intestinal microecological regulator of the present embodiment is prepared with the following raw materials: 210 parts of chinensis, 165 parts of grape leaves, 240 parts of raspberries, and purslane 210 parts, 140 parts of Polygonatum, 100 parts of Cistanche, 16 parts of yeast β-glucan, 24 parts of oligofructose, 30 parts of soybean oligosaccharide.

[0055] The preparation method of the liver-gut axis-based intestinal microecological regulator is as follows:

[0056] (1) Separately preparing extracts of Euphorbia serrata, extracts of Snake dentata grape leaves, and extracts of raspberries;

[0057] After crushing the 24 mesh sieve, the green grass or Snake Snake grape leaves or raspberries are added to the extraction tank, and 20 times the amount of 55% ethanol is added as the extraction solvent, and the extraction is carried out at room temperature for 50s; the flash extractor and vacuum are turned on The connection valve...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a liver protection intestinal micro-ecological modulator based on a gut-liver axis and a preparation method of the modulator. The modulator comprises, by weight, 100-300 partsof humifuse euphorbia herbs, 60-210 parts of ampelopsis grossedentata leaves, 100-300 parts of palmleaf raspberry fruits, 100-300 parts of purslane herbs, 60-180 parts of rhizome of king solomonseal,50-150 parts of herba cistanche, 5-20 parts of yeast beta-glucan, 10-50 parts of fructo-oligose and 10-60 parts of soybean oligosaccharides. Compared with an individually used drug or probiotic, thetherapeutic effect of the modulator is remarkably improved, the composition is guided by a traditional Chinese medicine life cultivation and health preservation theory and a modern medicine study 'gut-liver axis' theory, all components are matched with each other, realize synergistic interaction and are safe and free from toxic and side effects, dependence and drug resistance are avoided, the components cannot be accumulated in a body, and liver protection and intestinal modulation micro-ecological functions are exact. According to the preparation method, all main active components can be maximally retained, extract yield is improved, extraction time can be effectively shortened, and energy consumption is reduced.

Description

Technical field [0001] The invention relates to the field of biotechnology, in particular to a liver-protecting intestinal microecological regulator based on the liver-gut axis and a preparation method thereof. Background technique [0002] The liver is an organ whose main function is material metabolism and detoxification, while the intestine is an organ whose main function is to digest and absorb nutrients. It is generally believed that the two are independent and do not interfere with each other. With the development of science and technology and the deepening of research, more and more evidences show that the biological functions of the liver and the intestine are closely related and affect each other, and the theory of the "liver-gut axis" was born from this. In the embryonic stage, the liver and the intestine originate from the foregut. After maturation, the two organs are mainly related to each other through the portal vein: about 70% of the blood supply in the liver origi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/8969A61P1/16A61P1/00A61K31/716A61K31/702
CPCA61K31/702A61K31/716A61K36/185A61K36/47A61K36/64A61K36/73A61K36/87A61K36/8969A61K2236/333A61K2236/51A61K2236/53A61P1/00A61P1/16A61K2300/00
Inventor 贾福怀晏永球涂宏建王俊陶刚熊菲菲王彩霞袁媛许璐云
Owner NINGBO YUFANGTANG BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products