Composite mequindox injection for treating piglet diarrhea and preparation method of composite mequindox injection

Abstract

The invention discloses a composite mequindox injection for treating piglet diarrhea. The composite mequindox injection is prepared from the following raw material medicine components in parts by weight: 2-5 parts of mequindox, 15-20 parts of phenylcarbinol, 40-50 parts of absolute ethanol alcohol, 0.1-0.2 part of atropine sulfate, 0.2-0.5 part of sodium hydrogen sulfite and 20-45 parts of injection water. A preparation method comprises the following steps: putting mequindox into phenylcarbinol, stirring and dissolving completely at 45 DEG C, and further uniformly stirring with the absolute ethyl alcohol so as to obtain a liquid A; stirring and dissolving the atropine sulfate into 10% of the injection water completely, and further stirring and dissolving sodium hydrogen sulfite completelyso as to obtain a liquid B; mixing the liquid A with the liquid B, uniformly stirring, replenishing the injection water till 98-99% of the total weight, adjusting the pH value to 4.5-6.5, replenishingthe water till 100% of the total weight, uniformly stirring, filtering by using a filtering membrane of 0.45mu m, introducing nitrogen into an ampoule of 10ml, sealing, and sterilizing with circulated vapor at 100 DEG C for 30 minutes, thereby obtaining the composite mequindox injection. Due to scientific matching of the components, and the synergetic effects of the medicines, a good piglet diarrhea treatment effect can be achieved; animal tests show that the composite mequindox injection has a treatment rate up to 92.8% or greater and is low in reoccurrence rate.

Description

technical field [0001] The invention relates to veterinary drugs, in particular to a compound acemetquine injection for treating piglet diarrhea and a preparation process thereof. Background technique [0002] Porcine diarrhea is one of the most common diseases in the pig breeding industry, especially because piglets have not yet established a stable micro-ecosystem in the intestinal tract, their own resistance is low, they are sensitive to external stimuli, and they are particularly vulnerable to various pathogenic microorganisms and various The impact of stress factors leads to diarrhea. If no treatment measures are taken, dehydration, exhaustion, and death will soon occur, causing large economic losses. [0003] Infectious diarrhea is more common in suckling piglets, such as piglet yellow and white scour caused by Escherichia coli, and piglet paratyphoid fever caused by Salmonella; while nursery piglets are caused by non-infectious factors such as dietary antigen allerg...

AI Technical Summary

Problems solved by technology

[0005] During the process of diarrhea, piglets excrete a large amount of thin mushy or watery feces, and the piglets quickly develop symptoms of dehydration, functional failure, and death. Methoquine has a good inhibitory effect on pathogenic bacteria, but it cannot quickly control diarrhea symptoms, that is, cure the root cause Not treating the symptoms, it is often difficult to receive a good therapeutic effect when diarrhea emerges

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