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Bone-cartilage integrated repair scaffold and preparation method thereof

A cartilage repair and bone repair technology, used in prostheses, manufacturing tools, additive manufacturing, etc., can solve the problems of prone to fibrosis, inability to form tissues, joint degeneration, etc., to speed up the repair rate, promote tissue regeneration, and be less prone to deformation. Effect

Active Publication Date: 2020-11-24
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In view of the technical problems existing in the bone-cartilage integrated repair scaffold in the prior art, for example: it will not restore the activity ability as soon as possible; it cannot form hyaline cartilage-like tissue after long-term use; it is prone to technical problems of fibrosis; it does not have long-term similar Due to the biological properties of natural cartilage tissue, joint degeneration will occur within a period of time; insufficient donors, poor interface bonding and rejection reactions, etc.

Method used

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  • Bone-cartilage integrated repair scaffold and preparation method thereof
  • Bone-cartilage integrated repair scaffold and preparation method thereof
  • Bone-cartilage integrated repair scaffold and preparation method thereof

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no. 1 approach

[0064] In the first embodiment of the present invention, a bone-cartilage integrated repair scaffold is provided. The bone-cartilage integrated repair bracket includes: a connected bone repair layer 1 and a cartilage repair layer 2; in the present invention, the connected bone repair layer 1 and cartilage repair layer 2 can be in direct contact, or through other feasible The active layer is connected.

[0065] In the present invention, the material of the bone repair layer 1 includes a biodegradable synthetic polymer compound and a powder component with osteogenic activity, and the material of the cartilage repair layer 2 includes a biodegradable synthetic polymer compound and a powder component with chondrogenic activity. Active powder component.

[0066] In the direction perpendicular to the bone repair layer 1 (the z direction of the bone repair layer 1), the length of the bone repair layer 1 of the present invention (for example: the thickness of the bone repair layer 1) ...

no. 2 approach

[0104] The second embodiment of the present invention provides a method for preparing a bone-cartilage integrated repair scaffold, including the step of using 3D printing technology to prepare the bone-cartilage integrated repair scaffold; the bone-cartilage integrated repair scaffold is the first implementation Bone-cartilage integrated repair scaffold in the way. The preparation method of the invention can retain the activity of each component in the bone-cartilage integrated repair scaffold, has higher safety and lower cost, is easy to shape, and is suitable for large-scale industrial production. Specifically, the preparation method of the present invention can be carried out according to the following steps:

[0105] Dissolving a biodegradable synthetic polymer compound in the first solvent as a matrix solution;

[0106] The matrix solution is divided into two parts, and the powder component with osteogenic activity and the powder component with chondrogenic activity are ...

no. 3 approach

[0122] The third embodiment of the present invention provides a bone-cartilage integrated repair scaffold according to the first embodiment of the present invention and a bone-cartilage integrated repair scaffold obtained according to the preparation method of the bone-cartilage integrated repair scaffold according to the second embodiment of the present invention The scaffold is used in cartilage defect repair products. The cartilage defect repair product of the present invention may be for repairing articular cartilage defects, more preferably for repairing full-thickness cartilage defects of the knee.

[0123] Usually the quality of repaired tissue is evaluated by its new tissue morphology. Natural articular cartilage belongs to hyaline cartilage and is composed of chondrocytes and ECM. The cells contained in the tissue of natural articular cartilage should be pure chondrocytes, and the secreted ECM should contain type II collagen and glycosaminoglycans. However, the carti...

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Abstract

The invention provides a bone and cartilage integrated repair support and a preparation method thereof. The bone and cartilage integrated repair support comprises a bone repair layer and a cartilage repair layer connected with the bone repair layer; the bone repair layer comprises a biodegradable synthetic polymeric compound and a powder component with osteogenic activity; and the cartilage repairlayer comprises a biodegradable synthetic polymeric compound and a powder component with a cartilage formation activity. The bone and cartilage integrated repair support can stimulate a defect part of cartilages and sub-cartilage bones in a targeted way and facilitates tissue regeneration. Further, the cartilage recovered layer of the support includes cartilage cells, so that cartilage repair canbe accelerated, and the cartilage repair quality is improved.

Description

technical field [0001] The invention relates to a bone-cartilage integrated repair bracket and a preparation method thereof, belonging to the field of medical implant materials. Background technique [0002] Articular cartilage degeneration or lesions caused by trauma, disease, or external loads borne by long-term joint activities are common clinical symptoms. The inside of articular cartilage has no blood supply, no nerve, no immune response, and almost no self-healing ability. Once it encounters disease or injury, it will gradually deteriorate, eventually leading to motor dysfunction and joint diseases, which greatly affect the quality of life. Articular cartilage Advanced damage may even require artificial joint replacement. Studies have shown that cartilage and subchondral bone are a whole, the former acts as a load, and the latter acts as a mechanical support and absorbs impact. The two are interdependent and inseparable. [0003] Cartilage repair has made great progr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/28A61F2/30
CPCA61F2/28A61F2/30756A61F2002/2835A61F2002/30062A61F2002/30766A61F2002/30985
Inventor 张婧邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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