Bone-cartilage integrated repair scaffold and preparation method thereof

Abstract

The invention provides a bone and cartilage integrated repair support and a preparation method thereof. The bone and cartilage integrated repair support comprises a bone repair layer and a cartilage repair layer connected with the bone repair layer; the bone repair layer comprises a biodegradable synthetic polymeric compound and a powder component with osteogenic activity; and the cartilage repairlayer comprises a biodegradable synthetic polymeric compound and a powder component with a cartilage formation activity. The bone and cartilage integrated repair support can stimulate a defect part of cartilages and sub-cartilage bones in a targeted way and facilitates tissue regeneration. Further, the cartilage recovered layer of the support includes cartilage cells, so that cartilage repair canbe accelerated, and the cartilage repair quality is improved.

Description

technical field

[0001] The invention relates to a bone-cartilage integrated repair bracket and a preparation method thereof, belonging to the field of medical implant materials. Background technique

[0002] Articular cartilage degeneration or lesions caused by trauma, disease, or external loads borne by long-term joint activities are common clinical symptoms. The inside of articular cartilage has no blood supply, no nerve, no immune response, and almost no self-healing ability. Once it encounters disease or injury, it will gradually deteriorate, eventually leading to motor dysfunction and joint diseases, which greatly affect the quality of life. Articular cartilage Advanced damage may even require artificial joint replacement. Studies have shown that cartilage and subchondral bone are a whole, the former acts as a load, and the latter acts as a mechanical support and absorbs impact. The two are interdependent and inseparable.

[0003] Cartilage repair has made great progr...

Images