Artificial blood vessel and preparation method thereof

A technology for artificial blood vessels and vascular stents, which is applied in the fields of blood vessels, human tubular structures, medical science, etc., can solve the problems of slow degradation of vascular stents, mismatch of the growth and proliferation speed of inoculated cells, and slow growth of inoculated cells. , to achieve fast degradation rate, facilitate rapid fusion and rapid replacement, and increase the effect of growth and proliferation rate

Active Publication Date: 2018-12-18
HARBIN INST OF TECH AT WEIHAI
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, the seeded cells of the existing artificial blood vessels proliferate and form a film on the inner wall of the artificial blood vessel inner layer stent. With the continuous degradation of the inner layer stent, the middle layer stent, and the outer layer stent, the cells gradually grow and proliferate to form the middle layer and the outer layer. Among them, the main problem is that the degradation...

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  • Artificial blood vessel and preparation method thereof
  • Artificial blood vessel and preparation method thereof
  • Artificial blood vessel and preparation method thereof

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Embodiment 1

[0038] Depend on Figure 1 to Figure 8 As shown, the present invention provides an artificial blood vessel, which is composed of a vascular stent and seeded cells. The vascular stent is sequentially composed of a closely connected inner layer stent 1, an intermediate layer stent 2 and an outer layer stent 3. The inner layer stent 1 is made of poly A layer of porous fibrous tubular structure composed of ethylene succinate and anticoagulant; polyethylene succinate has good mechanical properties and good biocompatibility, making endothelial cells in the inner layer scaffold after implantation 1 Rapid endothelialization on the inner wall of the skin, the anticoagulant greatly reduces the formation of thrombus and improves the success rate of implantation; as the polyethylene succinate gradually degrades, the anticoagulant is gradually released to play a continuous and effective anticoagulant effect . The middle layer support 2 is a layer of porous fiber tubular structure composed...

Embodiment 2

[0041] The preparation method of the artificial blood vessel of the above-mentioned embodiment 1 comprises the following steps:

[0042] (1), according to parts by weight, respectively weigh 10 parts of anticoagulant heparin, 20 parts of polyethylene succinate, 20 parts of hydrogel material collagen, 10 parts of bioceramic material tricalcium phosphate, growth factor 5 parts of VEGF121 and 20 parts of polybutylene succinate.

[0043] (2), fully dissolve and mix the anticoagulant, polyethylene succinate and an appropriate amount of volatile polar solvent chloroform in step (1), and then carry out electrospinning to prepare a porous fiber tubular Structure, the preparation of the inner layer stent 1 is completed; the electrospinning preparation method of the inner layer stent 1 is spin winding.

[0044] (3) After fully dissolving and mixing the hydrogel materials, bioceramic materials, and growth factors weighed in step (1) with an appropriate amount of acetic acid solution, th...

Embodiment 3

[0049] The preparation method of the artificial blood vessel of the above-mentioned embodiment 1 comprises the following steps:

[0050] (1), according to parts by weight, take respectively 20 parts of anticoagulant sodium oxalate, 50 parts of polyethylene succinate, 40 parts of hydrogel material collagen, 20 parts of bioceramic material hydroxyapatite, 10 parts of growth factor VEGF145, 30 parts of polybutylene succinate.

[0051] (2), fully dissolve and mix the anticoagulant, polyethylene succinate and an appropriate amount of volatile polar solvent dichloromethane in step (1) and then carry out electrospinning to prepare a layer of porous The fiber tubular structure completes the preparation of the inner layer stent 1; the electrospinning preparation method of the inner layer stent 1 is spin winding.

[0052] (3) After fully dissolving and mixing the hydrogel materials, bioceramic materials, and growth factors weighed in step (1) with an appropriate amount of acetic acid s...

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Abstract

The invention provides an artificial blood vessel and a preparation method thereof which help solve a technical problem that degradation speed of a conventional artificial blood vessel is not matchedwith growth and proliferation speed of inoculated cells. The artificial blood vessel consists of a vascular stent and the inoculated cells; the vascular stent consists of a inner layer stent, an intermediate layer stent and an outer layer stent that are all connected tightly in order; the inner layer stent is a porous fiber circular tube-shaped structure formed by polyethylene succinate and an anticoagulant; the intermediate layer stent is a porous fiber circular tube-shaped structure formed by hydrogel-based material, bioceramic material, and growth factors; the inoculated cells are adhered to pores of the intermediate layer stent which are filled by the inoculated cells; the outer layer stent is a porous fiber circular tube-shaped structure formed by the polybutylene succinate; the invention also discloses a preparation method of the artificial blood vessel which can be widely applied to the field of implantable medical devices.

Description

technical field [0001] The invention relates to the field of implantable medical devices, in particular to an artificial blood vessel and a preparation method thereof. Background technique [0002] At present, cardiovascular disease and peripheral arterial disease are the main causes of human death in the world. Approximately 600,000 vascular grafts are performed each year, but nearly one-third of patients cannot use autologous blood vessels because of vascular aging, vascular disease, injury or previous surgical use. Currently commonly used stent materials mainly include non-degradable vascular stent materials and degradable vascular stents. Non-degradable vascular stents mainly include stainless steel, nickel-titanium alloy and other materials. These metal materials are not degradable in the human body and need to be kept in the body permanently, which increases the risk of restenosis. In this case, the use of degradable artificial blood vessels has become a good choice....

Claims

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Application Information

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IPC IPC(8): A61F2/06B33Y80/00B33Y10/00
CPCA61F2/06A61F2240/001B33Y10/00B33Y80/00
Inventor 张鹏刘康王传杰孙金平陈刚
Owner HARBIN INST OF TECH AT WEIHAI
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