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47results about How to "Slow proliferation" patented technology
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Multiwell plate
ActiveUS9200245B2Slow proliferationLow cytotoxicityBioreactor/fermenter combinationsBiological substance pretreatmentsEngineeringLiving cell
Owner:SENG ENTERPRISES
Compositions comprising Anti-proliferative agents and use thereof
InactiveUS20090264291A1Prevent proliferationPowerful anti-mutagenicPlant growth regulatorsCosmetic preparationsDormancyAqueous extract
The invention relates to anti-proliferative aqueous extracts derived from plants, the extracts comprising compounds capable of inducing a plant organ into a state of dormancy or maintaining the organ in the state of dormancy. The invention further discloses cosmetic, pharmaceutical and agricultural compositions comprising the anti-proliferative extracts and use thereof.
Owner:I B R ISRAELI BIOTECH RES
Aptamer-mediated regulation of gene expression
InactiveUS6949379B2Slow proliferationUndesirable cell proliferationFungiSugar derivativesRegulator geneNucleic acid molecule
This invention provides methods of regulating gene expression. An aptamer is positioned in a nucleic acid molecule along with a sequence encoding a transcriptional regulatory polypeptide. The aptamer disrupts translation of the transcriptional regulatory polypeptide when contacted with an aptamer-binding ligand. Gene expression levels can be either increased or decreased by the disclosed methods, depending on whether the transcriptional regulatory polypeptide is a repressor or activator, and the degree of the effect is dependent upon the dose of the ligand. Nucleic acid molecules, expression cassettes, expression vectors and cells useful in the gene regulation methods are also provided.
Owner:CANJI
Bioactive botanical cosmetic compositions and processes for their production
InactiveUS20110212190A1Inhibitory activityEnhance antiproteolytic activityCosmetic preparationsBiocideDermatologyBiological activity
The present invention is directed to bioactive botanical cosmetic compositions derived from membrane and cell serum fractions of plant cell juice. The present invention also relates to the methods for preparing these bioactive botanical cosmetic compositions and the uses of these compositions in various cosmetic formulations and as topical skin cosmetic applications.
Owner:ISP INVESTMENTS LLC
Compositions comprising anti-proliferative agents and use thereof
InactiveUS20060160702A1Reduction in signPromotion of skin firmnessBiocideAnimal repellantsMammalian tissueBiology
The invention relates to anti-proliferative agents derived from plants, wherein the agents are capable of inducing a plant organ into a state of dormancy or maintaining the organ in the state of dormancy. The invention further discloses compositions comprising the anti-proliferative agents and the use of said compositions to inhibit undesired or deleterious cell proliferation in plant or mammal tissue.
Owner:I B R ISRAELI BIOTECH RES
Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof
InactiveUS20130171110A1High expressionAccelerate self-renewalBiocideCulture processInduced pluripotent stem cellAntioxidant
Compositions and methods that employ various combinations of such factors as retinoic acid signaling inhibitors, antioxidants, BMP4, VEGF, prostaglandin E2 pathway stimulants, TPO, SCF, FLT-3, EPO, TGFβ1, p38 MAPK inhibitors, beta adrenergic receptor agonists, cell cycle inhibitors, RXR agonists, Cripto, and chromatin remodelers to drive differentiation of pluripotent stem cells towards primitive blood cells. Uses of such primitive blood cells are provided.
Owner:NUCLEUS BIOLOGICS LLC
Cancer stem cell-targeted cancer therapy
InactiveUS20080118518A1Stabilizing and reducing and cell populationPromote growthBiocideAntibody ingredientsRegimenCancer cell
The present invention provides methods for stabilizing, reducing or eliminating cancer cells. In particular, the present invention provides prophylactically and / or therapeutically effective regimens for the prevention, treatment and / or management of cancer, the regimens comprising administering one or more cancer therapies to a subject to reduce a cancer cell population. The therapy(ies) in the prophylactically and / or therapeutically effective regimen can be administered at a lower dose than currently used or known to one of skill in the art and / or for a longer period of time and / or more frequently than currently administered or known to one of skill in the art.
Owner:STEMLINE THERAPEUTICS
Method for rapidly starting anaerobic ammonium oxidation reactor
InactiveCN102344197AReduce churnReduce startup timeTreatment with anaerobic digestion processesBamboo charcoalAnaerobic sludge
The invention discloses a method for rapidly starting an anaerobic ammonium oxidation reactor. With an up-flow anaerobic sludge blanket digestion adopted, the method comprises the following steps of: adding mixed sludge composed of anaerobic digested sludge and sludge of a secondary sedimentation tank of a sewage treatment plant into a reactor, then adding bamboo charcoal particles with the diameter of 3-5mm, specific area of 14.0-31.2m<2> / g, density of 750kg / m<3> and volume density of 520kg / m<3>; and under airtight and shading conditions, inputting simulated waste water into a reactor to carry out continuous culture starting, wherein operating conditions are that: temperature of the reactor is maintained to be 25-35 DEG C, pH of waste water is 7.0-8.0, hydraulic power retention period is 24-48 hours, and concentration ratio of simulated waste water ammonia nitrogen to nitrite nitrogen is 1: (1.0-1.5). The method disclosed by the invention is convenient to apply, has low cost, can greatly reduce starting time of the anaerobic ammonium oxidation reactor and has wide application prospect to low carbon nitrogen ratio waste water.
Owner:ZHEJIANG UNIV
Bioactive botanical cosmetic compositions and processes for their production
InactiveUS8277852B2Inhibitory activityEnhance antiproteolytic activityCosmetic preparationsBiocideDermatologyBiological activity
The present invention is directed to bioactive botanical cosmetic compositions derived from membrane and cell serum fractions of plant cell juice. The present invention also relates to the methods for preparing these bioactive botanical cosmetic compositions and the uses of these compositions in various cosmetic formulations and as topical skin cosmetic applications.
Owner:ISP INVESTMENTS LLC
Bioactive botanical cosmetic compositions and processes for their production
InactiveUS20090017144A1Inhibitory activityEnhance antiproteolytic activityBiocideCosmetic preparationsPlant cellDrug biological activity
The present invention is directed to bioactive botanical cosmetic compositions derived from membrane and cell serum fractions of plant cell juice. The present invention also relates to the methods for preparing these bioactive botanical cosmetic compositions and the uses of these compositions in various cosmetic formulations and as topical skin cosmetic applications.
Owner:ISP INVESTMENTS LLC
Aptamer-mediated regulation of gene expression
InactiveUS20060128649A1Slow proliferationUndesirable cell proliferationSugar derivativesGenetic material ingredientsRegulation of gene expressionGene expression level
This invention provides methods of regulating gene expression. An aptamer is positioned in a nucleic acid molecule along with a sequence encoding a transcriptional regulatory polypeptide. The aptamer disrupts translation of the transcriptional regulatory polypeptide when contacted with an aptamer-binding ligand. Gene expression levels can be either increased or decreased by the disclosed methods, depending on whether the transcriptional regulatory polypeptide is a repressor or activator, and the degree of the effect is dependent upon the dose of the ligand. Nucleic acid molecules, expression cassettes, expression vectors and cells useful in the gene regulation methods are also provided.
Owner:CANJI
Starting method for rapid and efficient short-cut nitrification
ActiveCN104129853ASlow proliferationSolve efficiency problemsTreatment with aerobic and anaerobic processesSequencing batch reactorAmmoniacal nitrogen
The invention discloses a starting method for rapid and efficient short-cut nitrification. The method comprises the following steps: guiding inoculated sludge which is rich in nitrobacteria into an SBR (Sequencing Batch Reactor) reactor; guiding sewage into the SBR reactor in order that the concentration of the sludge in the reactor becomes 2,500-3,500mg / L, and controlling the temperature of the sewage at 30+ / -1 DEG C and the pH of the sewage at 7.9-8.2; starting an aeration facility in the reactor in order that the concentration of dissolved oxygen becomes 0.8-1.2mg / L; performing aeration for 1.5-2.5 hours; stopping aeration, and starting to stir for 0.5-1.5 hours to uniformly mix the sludge and the sewage; repeatedly aerating and stirring operation for 1-5 times; standing the mixture for separating a solid from a liquid; and draining supernatant. By performing the short-cut nitrification in an intermittent aeration way, the growth of AOB (Ammonia Oxidizing Bacteria) can be better facilitated, a nitrification reaction is restrained, the energy consumption of a reaction device can be lowered effectively, and the starting of the short-cut nitrification of domestic sewage with low ammonia nitrogen content can be realized in comparison to the conventional continuous aeration.
Owner:GUANGZHOU MUNICIPAL ENG DESIGN & RES INST CO LTD
Hematopoietic growth factor inducible neurokinin-1 gene
Bone marrow (BM) is the major organ where immune cells are derived. Homeostasis in the BM is maintained by inter- and intra-cellular interactions by the various subsets of BM cells. The present invention discloses the cloning of a new cDNA from stimulated BM stromal cells that was retrieved with a probe specific for the neurokinin-1 (NK-1) receptor. The cloned cDNA was designated ‘Hematopoietic Growth Factor Inducible Neurokinin-1 type’ (HGFIN) gene based on its expression in differentiated hematopoietic cells. Hence, the present invention provides a novel gene, HGFIN, which encodes a protein receptor that is involved in the regulation of hematopoietic proliferation and differentiation. The protein of the present invention may be involved as a central mediator of white blood cell, progenitor, differentiation, and therefore, may be useful in the prevention and treatment of lymphoproliferative syndromes such as B-cell related maladies, including but not limited to acute and chronic myeloid and lymphocytic leukemia as well as the B-cell subtype of Hodgkin's and non-Hodgkin's lymphomas.
Owner:RUTGERS THE STATE UNIV
Methods for enhancing survival and/or proliferation of neural stem cells and neurite extension enhancers therefor pharmaceutical compostions containing neural stem cells assay methods and screening methods
InactiveUS20070098701A1High proliferation rateSlow proliferationBiocideNervous disorderNeural stem cellDrug
Problems to be Solved Methods for enhancing survival and / or proliferation of neural stem cells and pharmaceutical compositions containing neural stem cells prepared by such methods, together with methods for assaying factors enhancing survival and / or proliferation of neural stem cells and methods for screening for such factors. Means for Solving the Problem Either Galectin-1 is overexpressed in neural stem cells or neural stem cells are cultured in a liquid medium containing Galectin-1. Pharmaceutical compositions containing Galectin-1-overexpressing neural stem cells and pharmaceutical composition containing Galectin-1, prepared by the aforementioned methods, improve higher cerebral functions damaged by cerebral ischemia. Further, by seeding neural stem cells at clonal concentrations and determining whether the seeded neural stem cells are capable of proliferating in an assay medium to be assayed, whether the factor enhances survival and / or proliferation of neural stem cells is assayed and a factor enhancing survival and / or proliferation of neural stem cells are identified using this assay method.
Owner:KEIO UNIV
Method of microalgal biomass processing for high-value chemicals production, the resulting composition of butyrogenic algal slowly fermenting dietary fiber, and a way to improve colon health using a slowly fermenting butyrogenic algal dietary fiber
ActiveUS20190053523A1High yieldLow costOrganic active ingredientsUnicellular algaeChemical treatmentButyrate
A method to process microalgae biomass and produce high-value chemicals from microalgae biomass is disclosed. The method uses the same biomass cells to extract more than one component such as are lipids, water-soluble chemicals, carotenoids, polysaccharides and algae meal. The method is a sequence of physical and chemical treatments. Water soluble polysaccharides produced by the method exhibit properties of low viscosity at low shear thinning. A method for extracting dietary fiber from microalgal biomass is disclosed. Compositions of water-soluble polysaccharides that are fermented slowly by colon microbiota with less gas production than commercial dietary fiber FOS are disclosed. The present inventions described herein provide a method of improving colon health by increasing butyrate during a microalgal dietary fiber fermenting process by colonic microbiota.
Owner:BENMOUSSA MUSTAPHA
VEGF receptor antagonists
ActiveUS20050196396A1Shorten the progressSlow proliferationPeptide/protein ingredientsAntibody mimetics/scaffoldsOncologyPolynucleotide
Owner:ORBIS HEALTH SOLUTIONS
Rapid start method for anaerobic ammonia oxidation reactor
ActiveCN105923765AShort startup timeStart fastWater contaminantsTreatment with anaerobic digestion processesNutrient solutionMembrane bioreactor
The invention discloses a rapid start method for an anaerobic ammonia oxidation reactor. The rapid start method comprises the following steps: by using a dynamic membrane bioreactor and by taking aerobic sludge and / or anaerobic sludge as inoculums, controlling the concentration of ammonia nitrogen and nitrite nitrogen of fed water, feeding a nutrient solution, filtering off the water by using a dynamic membrane, and enabling the reactor to continuously operate for at least 30 days, thereby achieving rapid domestication and enrichment of anaerobic ammonium oxidation bacteria inside the bioreactor. The rapid start method is applicable to anaerobic ammonia oxidation denitrification treatment on municipal sewage and industrial wastewater, and has the advantages of rapid start, high treatment efficiency, stable system operation, good effluent effect, low cost and the like.
Owner:HEFEI UNIV OF TECH
Method for generating autologous melanocytes based on 3D suspension iPS (induced pluripotent stem cells) and application
ActiveCN108795842AReduce the ratioRaise the ratioCell dissociation methodsCulture processMelanocyteIn vivo
Owner:JIANGSU UNIV
Oil palm tissue culture breeding method
InactiveCN102715091ASolve the low proliferation and differentiation rateSlow proliferationHorticulture methodsPlant tissue cultureEmbryoBud
The invention belongs to the technical field of seedling tissue culture, and relates to an oil palm tissue culture breeding method. The method comprises the steps of: taking young oil palm embryo as explant, disinfecting and inducing callus; conducting adventitious bud culture to the callus, and later conducting multiplication; conducting rooting culture to the multiplicated adventitious buds; and exercising rooted seedling, and transplanting into disinfected culture medium for culturing, thus obtaining oil palm regeneration plant. By taking young oil palm embryo as explant and obtaining regenerated plant through induced differentiation, the method solves the problems that the current oil palm has low multiplication differentiation rate, slow multiplication and incapability of meeting large-scale planting, effectively shortens the seedling tissue culture time, and has the characteristics of being simple in process, short in culture period, high in rooting rate, high in transplantation survival rate, and the like, thus establishing a good basis for industrialized and large-scale oil palm seedling, and providing precedent conditions for the oil palm industrialization development.
Owner:COCONUT RES INST OF CHINESE ACAD OF TROPICAL AGRI SCI +1
Application of human miR-26b in preparation of drugs for inhibiting fat cell proliferation
InactiveCN103432595APrevent proliferationDecreased number of cellsMetabolism disorderGenetic material ingredientsHuman fatGene engineering
The invention belongs to the field of gene engineering and discloses the application of human miR-26b in the preparation of drugs for inhibiting fat cell proliferation. The invention provides a technical scheme of applying human miR-26b in the preparation of drugs for inhibiting fat cell proliferation. The study results provided in the invention show that the over-expression of human miR-26b in human fat cells can significantly inhibit the proliferation velocity and cell quantity of fat cells, and human miR-26b can be used to prepare drugs for inhibiting fat cell proliferation and drugs for weight loss.
Owner:NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
VEGF receptor antagonists
ActiveUS7582726B2Shorten the progressSlow proliferationPeptide/protein ingredientsAntibody mimetics/scaffoldsVEGF receptorsCancer therapy
Owner:ORBIS HEALTH SOLUTIONS
Anti-KIR3D antibodies
Owner:INNATE PHARMA SA
Compositions for Intratumoral Administration
ActiveUS20110112123A1Inhibit migrationImprove tumor stiffnessBiocidePharmaceutical delivery mechanismMedicinePharmacology
Owner:TYCO HEALTHCARE GRP LP
Heterologous or heterogenic decelled epidermis substitute used for human fibroblast-like cell modification
A human fibroblast modified foreign cell-removed epidermis substitute with high bioactivity and affinity is prepared through treating the human fibroblasts by mitomycin C, inoculating them on the surface of foreign cell-removed epidermis substitute, and external culture to become the epidermis substitute containing single or double layers of human fibroblasts.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Rapid startup device and method for normal-temperature shortcut nitrification of urban sewage with low C/N ratio
PendingCN108640265APromote growthReduce energy consumptionWater treatment parameter controlBiological treatment regulationSequencing batch reactorRepeated treatment
The invention discloses a rapid startup device and method for normal-temperature shortcut nitrification of urban sewage with low C / N ratio. The device comprises an SBR (sequencing batch reactor), wherein an aeration device, a DO sensor, a stirring device and a pH sensor are arranged in the SBR; the SBR is connected with a water inlet pump and a water outlet pump through pipes; a sludge discharge pipe is arranged at the bottom of the SBR. Meanwhile, the rapid startup method for normal-temperature shortcut nitrification of the urban sewage with the low C / N ratio is disclosed and comprises the following steps: (1) inoculation; (2) sewage feeding; (3) aeration; (4) standing for discharging; (5) repeated treatment; (6) pH shock. Growth of AOB can be promoted better, nitrification is inhibited,energy consumption of a reaction device can be reduced effectively, startup period for shortcut nitrification is shortened, and rapid startup for shortcut nitrification of domestic sewage with low ammonia nitrogen content can be realized.
Owner:GUANGZHOU MUNICIPAL ENG DESIGN & RES INST CO LTD
Methods for enhancing survival and/or proliferation of neural stem cells and neurite extension enhancers therefor pharmaceutical compositions containing neural stem cells assay methods and screening methods
InactiveUS7785596B2Slow proliferationHigh proliferation rateNervous disorderPeptide/protein ingredientsLiquid mediumAssay
Owner:KEIO UNIV
Method of microalgal biomass processing for high-value chemicals production, the resulting composition of butyrogenic algal slowly fermenting dietary fiber, and a way to improve colon health using a slowly fermenting butyrogenic algal dietary fiber
ActiveUS10485253B2High yieldLow costOrganic active ingredientsUnicellular algaeChemical treatmentLipid formation
Owner:BENMOUSSA MUSTAPHA
Coated fertilizer for promoting growth of strawberry root system and preparation method thereof
The invention discloses a coated fertilizer for promoting the growth of a strawberry root system. The coated fertilizer is characterized by being prepared from the following raw materials in parts by weight: 19-26 parts of sauce residue powder, 14-19 parts of waste Chinese medicine residue powder, 0.4-1.0 part of ferrous sulfate, 0.3-0.5 part of manganese sulfate, 0.03-0.05 part of NAA, 0.06-0.2 part of compound sodium nitrophenolate, 3-5 parts of vermiculite powder, 10-13 parts of green grass powder, 12-15 parts of rice bran, 16-21 parts of rape seed cake, 15-19 parts of ammonium dihydrogen phosphate, 1-2 parts of dicyandiamide, 3-5 parts of tung oil, 13-16 parts of sweet wormwood extract, 7-14 parts of urea, 7-9 parts of EM bactericide, 9-12 parts of soil conditioner and a proper amount of water. Nutrient elements which are balanced in a nutrient formula and furthest meet the growth requirement of crops are designed according to low strawberry reproduction coefficient and low multiplication rate, and the fertilizer is released slowly, has the effects of protecting soil, killing pests and adsorbing harmful substances in soil, is rich in nutrients and provides a good growth environment for growth and multiplication.
Owner:HUAINAN YINONG MELON & FRUIT PRODION & MARKETING SERVICE
Method for separating and culturing vaginal epithelial cells
ActiveCN111088219APromote growthSlow proliferationCell dissociation methodsEpidermal cells/skin cellsMatrigelVaginal epithelial cell
The invention discloses a method for separating and culturing vaginal epithelial cells. The method for separating and culturing vaginal epithelial cells comprises the following steps: shredding a tissue, first digesting the tissue with a digestive fluid A, then performing sieving with a 70-micron cell sieve, and collecting cells; adding a mixed digestive fluid into the remaining tissue for furtherdigestion, then performing sieving with a 70-micron cell sieve, and collecting cells; and centrifuging the two collected cells, washing the cells with a culture medium for a plurality of times, and spreading the cells in a Matrigel pre-coated cell culture plate to obtain the vaginal epithelial cells. According to the method, the vaginal epithelial cells are obtained by performing digestion and separation twice on the vaginal tissue by pancreatin containing EDTA and the mixed digestive fluid for the first time. The growth and amplification of the vaginal epithelial cells can be maintained by culturing the vaginal epithelial cells through an optimized KSFM culture medium.
Owner:NANJING DRUM TOWER HOSPITAL +1
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