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Adsorbent for hemoperfusion and aqueous solution to remove endotoxin and preparation method thereof

A blood perfusion and aqueous solution technology, applied in chemical instruments and methods, blood circulation treatment, other chemical processes, etc., can solve the problems of low ligand content and low endotoxin adsorption performance.

Active Publication Date: 2021-12-31
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the residual double bonds on the surface of the porous carrier are less, so the amount of immobilized ligands is less, and the adsorption performance for endotoxin is lower
In addition, although the program reduces the residue of carcinogenic substances, it still uses a lot of highly toxic chemical reagents

Method used

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  • Adsorbent for hemoperfusion and aqueous solution to remove endotoxin and preparation method thereof
  • Adsorbent for hemoperfusion and aqueous solution to remove endotoxin and preparation method thereof
  • Adsorbent for hemoperfusion and aqueous solution to remove endotoxin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1) Grafting solution configured for ultraviolet irradiation grafting: configure the grafting solution of HEMA, BP and BA, wherein the volume fraction of HEMA is 10%, the volume fraction of BA is 90%, and the concentration of BP is 0.2g / 100mL, stir to dissolve evenly, set aside.

[0040] 2) Fully wet the non-woven fabric with the grafting solution: A polybutylene terephthalate (PBT) disc with a pore size of 300 μm, a thickness of 2 mm, and a diameter of 10 cm was immersed in excess grafting solution for 3 minutes.

[0041] 3) UV radiation grafting modified non-woven fabric: take out the non-woven fabric fully wetted by the grafting solution from the grafting solution, drain it at room temperature for 3 minutes, and place it under a UV light source under ventilated conditions. UV radiation grafting reaction for 20 minutes. The main peak of the ultraviolet light source is 365nm, the power is 30W / cm, and the vertical distance from the ultraviolet light source to the non-w...

Embodiment 2

[0044] 1) Grafting solution configured for UV irradiation grafting: configure the grafting solution of HEMA, BP and BA, wherein the volume fraction of HEMA is 25%, the volume fraction of BA is 75%, and the concentration of BP is 2g / 100mL , stir to dissolve evenly, set aside.

[0045] 2) Fully wet the non-woven fabric with the grafting solution: A polyethylene terephthalate (PET) disc with a pore size of 100 μm, a thickness of 1 mm, and a diameter of 10 cm was immersed in excess grafting solution for 3 minutes.

[0046] 3) UV radiation grafting modified non-woven fabric: take out the non-woven fabric fully wetted by the grafting solution from the grafting solution, drain it at room temperature for 3 minutes, and place it under a UV light source under ventilated conditions. UV radiation grafting reaction for 40 minutes. The main peak of the ultraviolet light source is 365nm, the power is 30W / cm, and the vertical distance from the ultraviolet light source to the non-woven fabric...

Embodiment 3

[0049] 1) Grafting solution configured for ultraviolet irradiation grafting: configure the grafting solution of HEA, BP and BA, wherein the volume fraction of HEA is 10%, the volume fraction of BA is 90%, and the concentration of BP is 1.0g / 100mL, stir to dissolve evenly, set aside.

[0050] 2) Fully wet the PBT non-woven fabric with the grafting solution: immerse a PBT disc with a pore size of 50 μm, a thickness of 0.3 mm, and a diameter of 10 cm in the excess grafting solution for 3 minutes.

[0051] 3) UV radiation grafting modified non-woven fabric: take out the non-woven fabric fully wetted by the grafting solution from the grafting solution, drain it at room temperature for 3 minutes, and place it under a UV light source under ventilated conditions. UV radiation grafting reaction for 15 minutes. The main wave peak of the ultraviolet light source is 365nm, the power is 50W / cm, and the vertical distance from the ultraviolet light source to the non-woven fabric disc is 30...

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Abstract

The present invention relates to an adsorbent for hemoperfusion and aqueous solution to remove endotoxin and a preparation method thereof. The adsorbent is mainly formed by connecting non-woven fabrics with polyethyleneimine through graft chains in the form of covalent bonds or covalent groups; The preparation method mainly includes the steps of grafting and activating fibers on the surface of the nonwoven fabric and immobilizing polyethyleneimine ligands. The preparation method of the invention is simple, less environmental pollution, and the obtained adsorbent has good endotoxin adsorption performance, blood compatibility and safety.

Description

technical field [0001] The invention relates to the field of blood purification and water treatment, in particular to an adsorbent for hemoperfusion and aqueous solution to remove endotoxin and a preparation method thereof. Background technique [0002] A variety of conditions can trigger endotoxemia in the human body. These conditions include: under stressful conditions such as severe trauma and infection; systemic reticuloendothelial system dysfunction, decreased immune function, and excessive intestinal absorption of endotoxins that exceed the body’s Clearance ability; gastrointestinal mucosal ischemia, necrosis, barrier damage, a large amount of endotoxin released into the blood; endotoxin absorbed by the intestinal tract directly enters the systemic circulation from the collateral circulation due to liver dysfunction; infection of certain tissues and organs causes exogenous Endotoxin into the blood. [0003] Endotoxemia usually leads to fatal septic shock, multiple org...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/26B01J20/30A61M1/36
CPCA61M1/36B01J20/265
Inventor 董凡杨超
Owner JAFRON BIOMEDICAL
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