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Compositions and methods for treatment of influenza virus

A technology for influenza virus infection and composition, which can be applied in the directions of antiviral agents, active ingredients of heterocyclic compounds, pharmaceutical formulations, etc., and can solve problems such as failure to fully solve influenza symptoms and mortality.

Inactive Publication Date: 2018-12-21
VERSITECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these therapies still fail to adequately address influenza symptoms and associated mortality

Method used

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  • Compositions and methods for treatment of influenza virus
  • Compositions and methods for treatment of influenza virus
  • Compositions and methods for treatment of influenza virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0030] Study design: This is a phase 2b / 3 single-centre clinical trial utilizing randomized treatment group assignment and open-label treatment. Influenza A patients with laboratory confirmed pneumonia ( H3N2)-infected hospitalized patients. The study was designed so that there was an 18% difference in mortality among patients with severe influenza when treated with combination versus oseltamivir therapy alone; the calculated sample size was 93 patients per group (one-sided alpha level 0.05, power 80% ).

[0031] The study protocol was approved by the Institutional Review Board of the University of Hong Kong and the Hospital Authority and registered with ISRCTN, number 11273879. All patients provided written informed consent before randomization.

[0032] Research committee members and local researchers designed the study, collected and analyzed data, wrote the manuscript, and decided to submit the manuscript for publication. The study sponsor had no involvement in the stu...

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Abstract

Therapy for influenza using a combination of a neuraminidase inhibitor, a macrolide antibiotic, and a non-steroidal anti-inflammatory drug has been found to provide improved clinical outcomes and reduced incidence of viral quasispecies compared to conventional treatment with neuraminidase inhibitors alone. Effective treatment schedules are also provided. The drug combination can be used in concertwith a proton-pump inhibitor and / or an additional antibacterial antibiotic.

Description

technical field [0001] The field of the invention is antiviral compounds and therapies. Background technique [0002] Seasonal, pandemic and avian influenza are the most important circulating viral infections leading to hospitalization and death, especially in vulnerable groups such as the elderly and individuals with chronic diseases. The World Health Organization estimates that seasonal influenza kills 250,000-500,000 people worldwide each year. During the 2014-2015 season, an antigenically shifted A / Swiss / 9715293 / 2013-like H3N2 virus caused large outbreaks in Europe, North America, and Asia, resulting in increased morbidity and mortality compared with the 2013-14 season. In addition to seasonal influenza, sporadic avian influenza A (H5N1) and avian influenza A (H7N9) can lead to even higher mortality rates. [0003] Treatment and prevention of influenza is currently limited to neuraminidase inhibitors such as oseltamivir, zanamivir, peramivir and laninamivir. These com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/35A61K31/19A61K31/13A61K31/7048A61K31/192A61K31/4439A61P31/16
CPCA61K31/19A61K31/192A61K31/215A61K31/351A61K31/424A61K31/43A61K31/4439A61K31/7048A61K45/06A61P31/16A61K2300/00A61K31/365
Inventor I·洪K·特奥A·张J·陈M·福克J·刘袁国勇
Owner VERSITECH LTD