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Modification method of leucocyte filtering membrane

A technology for filtering membranes and leukocytes, applied in the field of leukocyte filtration, can solve problems such as hemolysis reaction and toxicity, and achieve the effects of high safety, improved adhesion and improved hydrophilicity

Active Publication Date: 2018-12-25
广州达济医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, at present, the use of acrylic acid grafted monomers can improve the hydrophilicity of the filter material well, but the surface of the treated filter material will inevitably remain with acrylic acid monomers and their homopolymers, which have certain toxicity and will cause Hemolytic reaction

Method used

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  • Modification method of leucocyte filtering membrane
  • Modification method of leucocyte filtering membrane
  • Modification method of leucocyte filtering membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1, a kind of modification method of leukocyte filtration membrane

[0035] S1. Cut the polybutylene terephthalate PBT melt-blown non-woven fabric into 10×10cm squares, put it in an ethanol solution with a volume concentration of 75%, and ultrasonically clean it 3 times, each time for 12min, and then use deionized water Ultrasonic cleaning 2 times, each 12min, the power of the ultrasonic treatment is 100W, dry, to obtain the non-woven fabric after cleaning;

[0036]S2. Put the non-woven fabric cleaned in step S1 completely into solution I for soaking, the solution I is an ethanol solution containing benzophenone and allyl polyoxyalkylene epoxy ether, and the solution The ethanol solution in I is the ethanol solution that volume concentration is 75%, and the solid-to-liquid ratio of described benzophenone and ethanol solution is 0.5g:1ml, and described benzophenone and allyl polyoxyalkylene epoxy The solid-to-liquid ratio of the base ether is 1g:0.2ml, the soa...

Embodiment 2

[0041] Embodiment 2, a kind of modification method of leukocyte filtration membrane

[0042] S1. Cut the polybutylene terephthalate PBT melt-blown non-woven fabric into 10×10cm squares, put it in an ethanol solution with a volume concentration of 80%, and ultrasonically clean it 4 times, each time for 12min, and then use deionized water Ultrasonic cleaning 2 times, each 12min, the power of the ultrasonic treatment is 120W, dry, to obtain the non-woven fabric after cleaning;

[0043] S2. Put the non-woven fabric cleaned in step S1 completely into solution I for soaking, the solution I is an ethanol solution containing benzophenone and allyl polyoxyalkylene epoxy ether, and the solution The ethanol solution in I is the ethanol solution that volume concentration is 80%, and the solid-liquid ratio of described benzophenone and ethanol solution is 0.6g:1ml, and described benzophenone and allyl polyoxyalkylene epoxy The solid-to-liquid ratio of the base ether is 1g:0.3ml, the soaki...

Embodiment 3

[0048] Embodiment 3, a kind of modification method of leukocyte filtration membrane

[0049] S1. Cut the polybutylene terephthalate PBT melt-blown non-woven fabric into 10×10cm squares, put it in an ethanol solution with a volume concentration of 85%, and ultrasonically clean it 3 times, each time for 10min, and then use deionized water Ultrasonic cleaning 2 times, each 10min, the power of the ultrasonic treatment is 150W, dry, to obtain the non-woven fabric after cleaning;

[0050] S2. Put the non-woven fabric cleaned in step S1 completely into solution I for soaking, the solution I is an ethanol solution containing benzophenone and allyl polyoxyalkylene epoxy ether, and the solution The ethanol solution in I is the ethanol solution that volume concentration is 85%, and the solid-liquid ratio of described benzophenone and ethanol solution is 0.8g:1ml, and described benzophenone and allyl polyoxyalkylene epoxy The solid-to-liquid ratio of the base ether is 1g:0.4ml, the soaki...

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Abstract

The invention belongs to the technical field of leucocyte filtering and particularly relates to a modification method of a leucocyte filtering membrane. The modification method includes: completely soaking washed PBT nonwoven fabric into an ethanol solution containing benzophenone and polyalkyl glycol allyl epoxyl ether, then soaking into an ethanol solution containing methacrylic acid-2-hydroxyethyl and polyalkyl glycol allyl epoxyl ether, performing ultraviolet irradiation after the soaking, and allowing the irradiated PBT nonwoven fabric to have reaction with a silane coupling agent to obtain the leucocyte filtering membrane. The leucocyte filtering membrane prepared by the method is high in grafting rate and free of hemolysis, has an evident protecting effect on erythrocytes and has anefficient filtration effect on leukocytes and thrombocytes in whole blood.

Description

technical field [0001] The invention belongs to the technical field of leukocyte filtration, and in particular relates to a method for modifying a leukocyte filtration membrane. Background technique [0002] Modern research has found that allogeneic reactions occur between the white blood cells of the blood donor and the white blood cell antibodies in the recipient's blood, which can easily cause some non-hemolytic heat reactions and some virus infections related to white blood cells. Therefore, it is of great significance to filter out leukocytes in blood preparations before blood transfusion. At the same time, platelets can induce the body to produce anti-platelet antibodies, which are autoantibodies that do not recognize their own tissues and organs and will attack their own tissues and organs, thereby causing damage. In order to reduce the side effects caused by platelet transfusion, it is necessary to study a filter that can remove platelets efficiently while removing ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/76B01D67/00A61M1/34
CPCA61M1/3496B01D67/0002B01D71/76
Inventor 王新平
Owner 广州达济医学科技有限公司
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