A kind of preparation method of fish oil soft capsule

A technology of soft capsules and fish oil, applied in capsule delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of low gel performance, non-disintegration, long disintegration time, etc. Achieve the effects of reducing disintegration time, eliminating purchase concerns, and expanding sales range

Active Publication Date: 2021-04-30
JIANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compared with mammalian gelatin, fish gelatin exhibits lower gel properties, especially gel melting temperature and gel temperature; on the other hand, it is found in practice that soft capsules made of fish gelatin are prone to cross-linking and Causes the disintegration time to be too long or even no disintegration, which seriously limits the development of fish gelatin instead of mammalian gelatin in the field of soft capsules

Method used

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  • A kind of preparation method of fish oil soft capsule

Examples

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Effect test

Embodiment 1

[0032] A preparation method for fish oil soft capsules, comprising the steps of:

[0033] 1) Prepare the contents of the capsules: dry and grind the Herbs officinalis and Digupi into powder, then add them to ethanol with a volume fraction of 50% for 3 hours, and then add fibers to the extracts Composite enzymatic hydrolysis solution with a mass percentage of 0.5% suzyme and 0.01% pectinase; adjust the pH of the extract to 5.5, keep it warm at 40-60°C, oscillate with ultrasonic waves, and enzymatically hydrolyze for 0.5h; After the enzymolysis, take the supernatant, repeat the extraction of the residue three times according to the above extraction and enzymolysis steps, and combine the supernatants extracted each time; evaporate the supernatant to a water content of 5%, add ethyl acetate Extraction is carried out to obtain ethyl acetate extract, and the ethyl acetate extract is evaporated to a paste, that is, to obtain the extract of P. Deep-sea fish oil: vitamin E=85:0.1, and...

Embodiment 2

[0039] A preparation method for fish oil soft capsules, comprising the steps of:

[0040]1) Prepare the contents of the capsules: dry and grind the Herbs officinalis and Digupi into powder, then add them into alcohol with a volume fraction of 60% ethanol for 3 hours of extraction, and then add fibers to the extracts respectively Composite enzymatic hydrolysis solution with 0.7% by mass percentage of suzyme and 0.04% by mass of pectinase; adjust the pH of the extract to 6.0, keep it warm at 40-60°C, oscillate with ultrasonic waves, and enzymatically hydrolyze for 1.0h; After the enzymolysis, take the supernatant, repeat the extraction of the residue 3 times according to the above leaching and enzymolysis steps, combine the supernatants extracted each time; evaporate the supernatant to a water content of 7%, add ethyl acetate Extraction is carried out to obtain ethyl acetate extract, and the ethyl acetate extract is evaporated to a paste, that is, to obtain the extract of P. De...

Embodiment 3

[0046] A preparation method for fish oil soft capsules, comprising the steps of:

[0047] 1) Prepare the contents of the capsules: dry and grind the Herbs officinalis and Digupi into powder, then add them to ethanol with a volume fraction of 70% for 3 hours, and then add fibers to the extracts Composite enzymolysis solution with 0.8% by mass percentage of suzyme and 0.07% by mass of pectinase; adjust the pH of the extract to 6.5, keep it warm at 40-60°C, oscillate with ultrasonic waves, and enzymatically hydrolyze for 1.5 hours; After the enzymolysis, take the supernatant, repeat the extraction of the residue three times according to the above extraction and enzymolysis steps, and combine the supernatants extracted each time; evaporate the supernatant to a water content of 12%, add ethyl acetate Extraction is carried out to obtain ethyl acetate extract, and the ethyl acetate extract is evaporated to a paste, that is, to obtain the extract of P. Deep-sea fish oil: vitamin E=90...

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Abstract

The invention discloses a method for preparing a fish oil soft capsule, which is characterized in that it comprises the following steps: 1) preparing the contents of the capsule; 2) preparing a fish gelatin solution, adding γ-polyglutamic acid to the fish gelatin solution to obtain Fish gelatin-γ-polyglutamic acid solution; 3) adding TG enzyme to the fish gelatin-γ-polyglutamic acid solution, reacting for a certain period of time, and killing the enzyme after the reaction to obtain a mixed solution; 4) glycerol and water Adding to the mixed solution and mixing evenly, vacuumizing, defoaming, filtering, and heat preservation to obtain the soft capsule body; 5) making a soft capsule by the capsule content and the soft capsule body according to a certain weight ratio. The invention uses the modified fish gelatin instead of the mammalian gelatin in the production process of the fish oil soft capsules, which can effectively improve the safety performance of the capsules, eliminate consumers' purchase concerns, and expand the sales range of the blood sugar-lowering fish oil soft capsules.

Description

technical field [0001] The invention belongs to the application technical field of fish gelatin, and in particular relates to a preparation method of fish oil soft capsules. Background technique [0002] Soft capsules are a new dosage form developed after tablets and injections. They can inject oily drugs, drug solutions or drug suspensions, pastes, or even drug solid powders and granules into capsules. Form sealed capsules of various sizes and shapes. Compared with other dosage forms, it has the characteristics of high bioavailability, uniform drug solution, good stability, safe sealing, accurate content, beautiful appearance, and masking bad smell. It is suitable for small dosage, hydrophobic drugs, and low melting point drugs. Various health care oils with high oil content are sensitive to light, unstable in case of heat and humidity, easy to oxidize and volatile in the production of drugs, and have been widely used in pharmaceuticals, food, cosmetics, household products...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/42A61K47/34A61K47/12A61K47/22A61K47/24A61K36/73A61K36/815A61K35/60A61P3/10A61P3/06
CPCA61K9/4808A61K9/4816A61K9/4825A61K35/60A61K36/73A61K36/815A61K2236/19A61K2236/333A61K2236/39A61K2236/55A61P3/06A61P3/10A61K2300/00
Inventor 涂宗财沙小梅叶云花张露刘俊
Owner JIANGXI NORMAL UNIV
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