Method for preparing hydroxyapatite coating on surface of titanium or titanium alloy

A technology of hydroxyapatite and titanium alloy, which is applied in the field of medical devices and can solve the problems of long time-consuming and low production volume

Active Publication Date: 2019-01-11
上海果真医疗科技中心(有限合伙)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These calcium phosphate compounds can be prepared by mixing calcium ions and phosphate ions in aqueous solutions under a variety of conditions, but are generally time-consuming and low-throughput

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A method for preparing a hydroxyapatite coating on the surface of a titanium alloy, characterized in that it comprises the following steps:

[0022] S1. Using bioactive glass particles as a sandblasting medium, sandblasting the surface of the titanium alloy, cleaning and drying after the treatment, to obtain a sandblasting substrate; the particle size of the bioactive glass particles is 50nm;

[0023] S2. Immerse the titanium alloy in an aqueous solution containing calcium ions, and keep it at room temperature for 30 seconds, and the concentration of the calcium ions is 0.1mol / L;

[0024] S3. Under vacuum conditions, provide phosphorus element vapor and ozone to collide with the surface of the substrate. The flow rate of phosphorus element vapor is 10 sccm, and the ozone flow rate is 1 sccm. By adjusting the temperature, the reaction of the component elements only occurs on the substrate to promote A low-crystalline, bioactive hydroxyapatite coating is formed on the sur...

Embodiment 2

[0027] A method for preparing a hydroxyapatite coating on the surface of a titanium alloy, characterized in that it comprises the following steps:

[0028] S1. Using bioactive glass particles as a sandblasting medium, sandblasting the surface of the titanium alloy, cleaning and drying after the treatment, to obtain a sandblasting substrate; the particle size of the bioactive glass particles is 200nm;

[0029] S2. Immerse the titanium alloy in an aqueous solution containing calcium ions, and keep it at room temperature for 60 seconds, and the concentration of the calcium ions is 2.0mol / L;

[0030] S3. Under vacuum conditions, provide phosphorus element vapor and ozone to collide with the surface of the substrate. The flow rate of phosphorus element vapor is 50 sccm, and the flow rate of ozone is 5 sccm. By adjusting the temperature, the reaction of the component elements only occurs on the substrate to promote A low-crystalline, bioactive hydroxyapatite coating is formed on the...

Embodiment 3

[0033] A method for preparing a hydroxyapatite coating on the surface of a titanium alloy, characterized in that it comprises the following steps:

[0034] S1. Using bioactive glass particles as a sandblasting medium, sandblasting the surface of the titanium alloy, cleaning and drying after the treatment, to obtain a sandblasting substrate; the particle size of the bioactive glass particles is 100nm;

[0035] S2. Immerse the titanium alloy in an aqueous solution containing calcium ions, and keep it at room temperature for 30 seconds, and the concentration of the calcium ions is 1.0mol / L;

[0036] S3. Under vacuum conditions, provide phosphorus element vapor and ozone to collide with the surface of the substrate. The flow rate of phosphorus element vapor is 1000 sccm, and the flow rate of ozone is 10 sccm. By adjusting the temperature, the reaction of the component elements only occurs on the substrate to promote A low-crystalline, bioactive hydroxyapatite coating is formed on ...

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Abstract

The invention provides a method for preparing a hydroxyapatite coating on the surface of titanium or titanium alloy. Firstly, an implant is immersed in an aqueous solution containing calcium ions; phosphorus vapor is provided by using a phosphorus cracker; under the vacuum condition, the phosphorus vapor and ozone collide with the surface of the substrate; and by controlling the deposition rate ofthe phosphorus and oxygen components, a reaction of the elements occurs only on the substrate, which promotes the formation of a low-crystalline hydroxyapatite coating with bioactivity on the surfaceof the implant.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a method for preparing a bioactive coating on the surface of titanium metal. Background technique [0002] In recent years, hydroxyapatite has been widely used as an artificial biomaterial capable of replacing hard tissues such as bones or teeth. Hydroxyapatite is a material that is chemically and crystallographically identical to the mineral components that make up human bones and teeth. When transplanted into the human body, hydroxyapatite exhibits high biocompatibility with surrounding cells and rapidly forms a direct chemical bond with bone at the junction zone. Pure hydroxyapatite crystals composed of calcium ions, phosphate ions, and hydroxyl ions are stoichiometric crystals with a rod-like structure and high crystallinity. On the other hand, biocrystals isolated from bone or calcified cartilage are non-stoichiometric hydroxyapatite with low crystallinity. In o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32C23C8/28
CPCC01B25/32C23C8/28
Inventor 曾晨光李少军许羽冬陈诗浩杨习锋
Owner 上海果真医疗科技中心(有限合伙)
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