Biomimetic stomach, preparation method thereof and application thereof

Abstract

The invention discloses a bionic stomach, a preparation method thereof and an application thereof, belonging to the bionic technology field and the biotechnology field. The biomimetic stomach of the invention is prepared by mixing a base material (one or more of silica gel, emulsion or hydrogel) and auxiliary materials (silicone oil and curing agent) according to a certain mass ratio, and applyingthe mixture to the fundus of stomach, stomach body and gastric antrum of a precise human gastric anatomy model of the medical digestive department. The bionic stomach of the invention has superior simulation performance, and has a real physiological structure of a real human stomach inner wall, can realize the function of grinding food by the stomach, and has extremely strong consistency in performance, structure and function with the real human stomach. The bionic stomach of the invention separates the bionic gastric antrum and the gastric body, respectively applies a certain pressure to theseparated gastric antrum and the gastric body, thereby realizing the back jet function between the gastric body and the gastric antrum, and therefore, the bionic stomach of the invention has a greatapplication prospect in the research process of foods and medicines.

Description

technical field [0001] The invention relates to a bionic stomach and its preparation method and application, belonging to the field of bionic technology and biotechnology. Background technique [0002] In the research process of food and medicine, it is very important to objectively and accurately evaluate the digestion process of food and medicine in the human body to determine the components of food and medicine and their effects on the human digestive tract. [0003] The human digestive tract in vitro simulation device (such as SHIME, IViDiS, TIM, DGM, HGS, etc.) is a device for bionic simulation of the human digestive system, its digestive environment, and the fluid dynamic behavior in the digestive tract. It can simulate different samples in an in vitro model. The digestive process of these samples and the influence of these samples on intestinal microorganisms provide a lot of valuable data for the research and development of new functional foods. If it is used as a "p...

AI Technical Summary

Problems solved by technology

[0007] However, the internal physiological structures of these existing digestive tract models made of silica gel and latex are smooth, do not have the function of grinding food, and can only truly simulate some liquid foods (beverages, milk, etc.) that do not need grinding. The digestive state in the stomach; for solid (rice, fruit, meat, etc.) or semi-solid (porridge, soup, etc.) food, they can only reflect the function of mixing food, and cannot truly reflect the grinding and digestion of food in the gastrointestinal tract function of

[0008] Moreover, these digestive tract models are often simply made as a whole structure, for example, a whole stomach is molded with silicone or latex at one time, and these whole stomachs cannot simulate the "back jet" function between the gastric antrum and the gastric body, resulting in The experimental results are not accurate

[0009] At the same time, these digestive tract models made of silica gel and latex are not satisfactory in terms of simulation performance, such as hardness, expansion rate, and elasticity, and there is still a certain gap with the real digestive tract of humans.

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