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Use of active compounds isolated from secondary metabolites of Aspergillus versicolor

A technology for secondary metabolites and Aspergillus versicolor, which is applied in the field of microbial medicine, can solve the problems of high difficulty in collecting marine samples and inability to fully express metabolites, and achieves the effects of convenient operation and reasonable design.

Active Publication Date: 2021-03-16
ZHEJIANG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the collection of marine samples is difficult, and only less than 5% of marine microorganisms have been isolated under routine laboratory conditions, and even the obtained microorganisms cannot fully express all their biosynthetic pathways in the marine environment metabolite

Method used

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  • Use of active compounds isolated from secondary metabolites of Aspergillus versicolor
  • Use of active compounds isolated from secondary metabolites of Aspergillus versicolor
  • Use of active compounds isolated from secondary metabolites of Aspergillus versicolor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The structural formula of the active compound isolated from the secondary metabolite of Aspergillus versicolor is:

[0056] in,

[0057]

[0058] 1. Inhibition of α-glucosidase by active compounds

[0059] Preparation of α-glucosidase solution: dissolve the enzyme freeze-dried powder with 0.1% BSA solution to prepare a 100U / mL enzyme solution, and place it in a -20°C refrigerator for cryopreservation. Before the experiment, draw a small amount of 100U / mL enzyme solution with a pipette, first dilute it to 20U / mL with 0.1%BSA solution, and then dilute it to 0.2U / mL with 0.1%BSA solution for use.

[0060] PNPG solution preparation: Weigh a certain amount of PNPG solid, dissolve it with 0.1mol / L phosphate buffered saline (PBS) with a pH of 6.8, and prepare it to a concentration of 10mmol / L, and then dispense it with a 1.5mL centrifuge tube.

[0061] The activity of α-glucosidase was determined by colorimetric method. The active compound to be tested was dissolved in...

Embodiment 2

[0071] Use of active compounds isolated from secondary metabolites of Aspergillus versicolor in the preparation of medicaments for the treatment of diabetes.

[0072] Tablet preparation: take 40g of active compound, 40g of edible cellulose, 15g of lactose, 0.3g of sodium citrate, 1g of magnesium stearate and an appropriate amount of tablet excipients, mix well, and make into tablets according to known tablet making technology and equipment The product specification is 0.5g / tablet.

Embodiment 3

[0074] Use of active compounds isolated from secondary metabolites of Aspergillus versicolor in the preparation of medicaments for treating diabetic nephropathy.

[0075] Preparation of granules: 38 g of active compound, 65 g of edible cellulose and an appropriate amount of granule auxiliary materials are mixed uniformly, and granulated by a spray drying process.

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Abstract

The present invention provides the use of active compounds isolated from secondary metabolites of Aspergillus versicolor, The present invention belongs to the technical field of microbial drugs and includes the use in the preparation of drugs for the treatment of diabetes and / or the use in the preparation of drugs for the prevention and / or treatment of diabetic complications and / or the use in thepreparation of drugs as insulin sensitizers. The present invention uses active compound to alpha-glucosidase The inhibitory effect of is better than that of acarbose, which has better effect on prevention and treatment of diabetes, especially type 2 diabetes, and the active compounds come from the secondary metabolites of microorganisms, belonging to natural [alpha]-glucosidase inhibitor, easy tobe absorbed by the body.

Description

technical field [0001] The invention belongs to the technical field of microbial medicine, and particularly relates to the use of active compounds separated from secondary metabolites of Aspergillus versicolor. Background technique [0002] The research history of terrestrial microorganisms for nearly a hundred years has led to the discovery of a large number of natural products with diverse chemical structures and significant biological activities, which have greatly promoted the development of biotin drugs, such as penicillin, vancomycin, streptomycin, etc. More and more attention to microorganisms naturally leads to repeated research on microorganisms and repeated development of known compounds, reducing the probability of discovering new compounds. Therefore, people have begun to pay attention to marine-derived microorganisms with larger microbial reserves and more diverse species. Due to its unique living environment (high pressure, high salinity, low temperature, olig...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/085A61P3/10A61P5/50A61P13/12A61P27/02A61P25/00A61P9/00
CPCA61K31/085A61P3/10A61P5/50A61P9/00A61P13/12A61P25/00A61P27/02
Inventor 孙坤来张译文刘文王斌初雪梅陈荫赵玉勤
Owner ZHEJIANG OCEAN UNIV
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