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Nano-hydroxyapatite composite material with tumor inhibiting effect and preparation method thereof

A technology of nano-hydroxyapatite and composite materials, which is applied in the direction of anti-tumor drugs, medical preparations of non-active ingredients, drug combinations, etc., can solve the problems of easy recurrence and metastasis, difficult to cure, and affect the inhibition of tumors, so as to reduce recurrence rate and metastasis rate, inhibition of tumor growth, and the effect of tumor inhibition

Active Publication Date: 2019-01-18
成都迪康中科生物医学材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the nano-hydroxyapatite particles are used, they need to be placed around the tumor cells and corresponding tissues, and a large amount of interstitial fluid produced after the operation will flush the fine hydroxyapatite particles out of the body along the drainage tube, to a great extent. The effect of its anti-tumor effect
In addition, although surgery is the only possible way to achieve a radical cure for the tumor, only about 10% of early-stage patients can undergo radical resection, and even if the patient undergoes surgical resection, it is easy to relapse and metastasis after surgery, and it is difficult to cure the tumor. % of patients treated with surgical resection died due to recurrence of tumor metastasis

Method used

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  • Nano-hydroxyapatite composite material with tumor inhibiting effect and preparation method thereof
  • Nano-hydroxyapatite composite material with tumor inhibiting effect and preparation method thereof
  • Nano-hydroxyapatite composite material with tumor inhibiting effect and preparation method thereof

Examples

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Effect test

Embodiment 1

[0028] Embodiment 1 A kind of nano-hydroxyapatite composite material with anti-tumor effect

[0029] The preparation method comprises the following steps:

[0030] 1, get purified water 300ml, add 15g starch, stir while adding, after the solution is uniform, measure the solution volume, then add 1g sodium hydroxide, measure the solution volume after cold taking, replenish the evaporated liquid volume with purified water, mix Evenly, mixed solution A was obtained;

[0031] II. Take 45g of nano-hydroxyapatite, add it to the mixed solution A obtained in step I, stir evenly, weigh it, react in a 90°C water bath for 40 minutes while stirring, until the starch is completely gelatinized, take it cold and weigh it, and replenish it with purified water Weight, mix well, get mixture B;

[0032] III. Take 3g of sodium trimetaphosphate and add it to the mixture B obtained in step II, stir at room temperature for 10 minutes, then heat and stir at 90°C for 15 minutes to obtain a gel, hea...

Embodiment 2

[0033] Example 2 A kind of nano-hydroxyapatite composite material with anti-tumor effect

[0034] The difference from Example 1 is that the weight ratio of starch to nano-hydroxyapatite in Example 2 is 1:1, and the remaining parameters and operations refer to Example 1.

Embodiment 3

[0035] Example 3 A nano-hydroxyapatite composite material with tumor-inhibiting effect

[0036]The difference from Example 1 is that the weight ratio of starch to nano-hydroxyapatite in Example 3 is 1:6, and the remaining parameters and operations refer to Example 1.

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Abstract

The invention belongs to the field of biomedical materials, in particular to a nano-hydroxyapatite composite material with tumor inhibiting effect and a preparation method thereof. The composite material is made of nano-hydroxyapatite and starch, and the weight ratio of the starch to nano-hydroxyapatite is 1: (0.5-6). The nano-hydroxyapatite and the gelatinized cross-linked starch are combined byhydrogen bonding, Hydroxyapatite can be uniformly distributed in the starch gel crosslinking system, which has good biocompatibility and high safety. It can inhibit tumor and promote tissue repair, and can effectively act on tumor site and significantly reduce the recurrence and metastasis rate after tumor resection.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a nano-hydroxyapatite composite material capable of inhibiting tumors and a preparation method thereof. Background technique [0002] Tumor refers to the new organism formed by the proliferation of local tissue cells under the action of various tumorigenic factors. At present, chemotherapy is one of the three major means of treating tumors. The antitumor drugs used mostly act on different links of tumor cell growth and reproduction, inhibit or kill tumor cells, but at the same time cause damage to normal somatic cells of the human body. . Chinese patent application CN104288784A discloses a nano-hydroxyapatite-gene-drug complex and its preparation method and application. The complex is composed of nano-hydroxyapatite, anti-tumor genes, and anti-tumor drugs. The salt solution is mixed to prepare nano-hydroxyapatite, the anti-tumor gene is adsorbed to form a nano-hy...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61K33/42A61K9/06A61K47/36A61P35/00A61P35/04
CPCA61K9/06A61K33/42A61K47/36A61L26/0004A61L26/0023A61L26/0066A61L26/008A61L26/009A61L26/0095A61L2300/112A61L2300/41A61L2300/412A61L2300/416A61L2400/04A61L2400/12A61P35/00A61P35/04C08L3/02
Inventor 王一夫李晓萍张凯王进巩阳
Owner 成都迪康中科生物医学材料有限公司
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