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74results about How to "Tumor suppressor" patented technology

Making method for powder sticked pacific saury slices

The invention relates to a making method for powder sticked pacific saury slices. The method includes: preferably selecting a fresh pacific saury as the raw material, subjecting the raw material pacific saury to scaling, decapitating, evisceration, fish blood and impurity removal, conducting carcass opening and separation on the fish body and the vertebra, making the fish body into fish slices, then washing and draining the fish slices, and putting them into a seasoning solution made of salt, garlic essential oil, kelp liquid, soy sauce, granulated sugar, ginger juice, lemon juice and water to undergo low temperature impregnation to be tasty, performing water controlling, then wrapping the outer surfaces of the fish slices with potato starch, and carrying out quick-freezing treatment so as to obtain nutrient-rich quick-frozen powder sticked pacific saury slices. The making method for powder sticked pacific saury slices provided by the invention has the characteristics of advanced technology, reasonable process, strong operability and high making efficiency. The made fish slices have the advantages of beautiful appearance, safety and sanitation, stable quality, long shelf life, fresh and mellow taste, palatable sweet and salty taste and unique flavor, and can be eaten after opening the package and frying.
Owner:HENGMAO IND GRP

Method for preparing conjugated linoleic acid short-chain alcohol ester

The invention discloses a method for preparing conjugated linoleic acid short-chain alcohol ester. The method comprises the following steps: taking vegetable oil as a raw material; carrying out one-step saponification and isomerization under a normal-pressure nitrogen filling condition; acidifying and washing with water; centrifuging to prepare a conjugated linoleic acid crude product; freezing, refining and separating to obtain a conjugated linoleic acid refined product; mixing the conjugated linoleic acid refined product with alcohol and adding an acidic catalyst; neutralizing, filtering and carrying out rotary evaporation; filtering to obtain the conjugated linoleic acid short-chain alcohol ester. Compared with the prior art, a reaction speed is effectively controlled, the generation of trans fatty acids is extremely reduced, the quality of the product is improved, the time of reaction operation is greatly reduced and the preparation efficiency is improved; the method has a simple process and is easy to operate and needed equipment investment is small; the conjugated linoleic acid short-chain alcohol ester prepared by the method has high stability, is not easy to oxidize and has various important physiological functions of inhibiting cancers, losing weight, adjusting blood lipid, regulating blood glucose, regulating blood pressure, resisting atherosclerosis, regulating immunity and the like.
Owner:ANHUI AGRICULTURAL UNIVERSITY

Preparation method of novel estrogen receptor protein ERbetaX and application thereof

The invention discloses a preparation method of a novel estrogen receptor protein ERbetaX and an application of the ERbetaX protein, and which prepares ERbetaX protein by using molecular biological techniques; separating and purifying by adopting molecular sieve gel chromatography, ion exchange resin and silica gel chromatography; identifying and analyzing the structure through a liquid chromatography-mass spectrometry instrument, an amino acid sequence analyzer or a nuclear magnetic resonance instrument; establishing animal models of mice and rats, and carrying out toxicological experiments of ERbetaX; determining the administration dosage and the route of ERbetaX; carrying out research on the activity and pharmacokinetics of ERbetaX protein by high performance liquid chromatography (HPLC); analyzing the specificity and affinity of ligands such as estradiol (E2), Tamoxifen (TAM) and the like; studying the role and mechanism of ERbetaX in various hormone-related tumors such as breast cancer, prostate cancer, cervical cancer, ovarian cancer and colorectal cancer by biological and molecular biology experiments. The preparation method of the novel estrogen receptor protein ERbetaX hassmall toxic and side effects and low production cost, and avoids pain caused by radiotherapy and chemotherapy of patients due to surgery.
Owner:JILIN UNIV

Compound medicine composition for improving oral bioavailability of paclitaxel and application of compound medicine composition

This application is the divisional application of an inventive patent application with the application number of 201110004638.9, the application date of January 11th, 2011 and the name of compound medicine composition for improving oral bioavailability of paclitaxel and the application of the compound medicine composition. The invention discloses a compound medicine composition for improving oral bioavailability of paclitaxel and the application of the composition. The invention further discloses a medicine composition comprising the compound medicine composition and paclitaxel monomer compounds. The compound medicine composition provided by the invention can be used for improving the oral bioavailability of the paclitaxel; and when being used for preparing anti-cancer drugs, the compound medicine composition can improve the anti-cancer effect of the paclitaxel. In the compound medicine composition provided by the invention, the paclitaxel is the main anti-cancer ingredient; the monomer compounds are extracted by traditional Chinese medicine; the oral bioavailability and anti-cancer effect of the paclitaxel are improved by inhibiting the first pass effect of the paclitaxel. Experimental investigation shows that the compound medicine composition provided by the invention is prepared into oral medicines so as to improve blood concentration and anti-cancer effect of the paclitaxel after oral administration.
Owner:SUN YAT SEN UNIV

Application of ethyl acetate part of caper in preparation of antitumor drugs

The invention relates to the technical field of medicines and in particular relates to application of an ethyl acetate part of caper in preparation of antitumor drugs. The invention further provides apreparation method of the ethyl acetate part of caper. The preparation method comprises the following steps: (1) with caper powder, performing reflux extraction with an alcohol aqueous solution, filtering, and performing vacuum concentration to obtain extract; and (2) dispersing the extract with water, sequentially extracting with petroleum ether, chloroform and ethyl acetate, concentrating and drying, thereby obtaining the ethyl acetate part. Possible positions achieving an antitumor effect in the ethyl acetate part prepared in the invention are total alkaloids; the tumor control rate of theethyl acetate part on transplanted H22 tumor-bearing mice reaches 38.2%; the life of ascitic tumor mice can be obviously prolonged; HE staining results show that tumor tissue cells are sparsely arranged, large-area necrosis occurs and great cytoplasm vacuolization is caused; and meanwhile, the ethyl acetate part does not have any obvious influence on immune organs, hepatic and renal functions andblood routine examination and has potential of being developed into a novel antitumor drug.
Owner:SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES

Compound pharmaceutical composition for improving oral bioavailability of paclitaxel and application thereof

This application is a provisional application of Ser. No. 201110004638.9, entitled Compound Pharmaceutical Composition for Improving Oral Bioavailability of Paclitaxel and Application thereof, filed on Jan. 11, 2011. The invention discloses a compound pharmaceutical composition for improving oral bioavailability of paclitaxel and application thereof. The invention also discloses a pharmaceutical composition containing the compound pharmaceutical composition and a monomeric compound of paclitaxel. The compound pharmaceutical composition provided in the invention can be used for improving oral bioavailability of paclitaxel and for preparing anti-cancer drugs and can enhance the anti-cancer effect of paclitaxel. In the compound pharmaceutical composition provided in the invention, paclitaxel is used as an anti-cancer main component, and the monomeric compound extracted from a traditional Chinese medicine improves oral bioavailability and the anti-cancer effect of paclitaxel by inhibiting the first pass effect of paclitaxel. According to experiments and research, the compound pharmaceutical composition, prepared into an oral drug, can enhance plasma concentration and the antineoplastic effect of paclitaxel.
Owner:SUN YAT SEN UNIV

A soft capsule of Ganoderma lucidum whole herb essence that detoxifies and protects liver, improves anti-radiation ability and inhibits tumor

The invention discloses a ganoderma lucidum whole grass essence soft capsule for expelling toxins, protecting the liver, improving anti-radiation ability and inhibiting tumor. The capsule comprises the following components in parts by weight: 60-70 parts of ganoderma lucidum extract, 0.2-0.7 part of ginkgo leaf extract, 0.2-0.5 part of tuber onion seed extract, 6-8 parts of kudzuvine root powder,1-2 parts of acerola cherry powder, 2-3 parts of wall-broken ganoderma lucidum spore powder, 5-8 parts of ganoderma lucidum spore oil, 1-2 parts of soybean lecithin, 2-3 parts of beeswax, 2-5 parts ofsoybean oil, 1-3 parts of gelatin and 3-6 parts of glycerol. The soft capsule of the invention can significantly reduce contents of serum glutamic pyruvic transaminase, glutamic oxalacetic transaminase, triglyceride and malondialdehydle in alcohol-model mice, significantly increase the glutathione content of the liver tissue, significantly increase the white blood cell count of the irradiated mice, increase the tumor inhibition rate of H22 tumor-bearing mice to 35-76%, and is a health food with obvious effects of expelling toxins, protecting the liver, improving anti-radiation ability and inhibiting tumor.
Owner:海南仙草南芝生物科技有限公司
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