A visual sensing array chip and its preparation method

Abstract

A visual sensor array chip, including a basement membrane, on which several sensitive substances are loaded, the sensitive substances are evenly arranged on the basement membrane, and the sensitive substances are respectively responsive materials containing metal ions, pH indicators and permanent dipole dyes . The preparation method is as follows: put the cut basement film into the spotting mold, and cover the mold cover with holes; in a protective atmosphere, sequentially dip the saturated solution of sensitive substances on the basement film to form an array, and through the micro-touch technology Make the sensitive substance adhere to the base film until it diffuses into dots of uniform size; slowly blow dry the visual sensing array chip prepared in step S2 with nitrogen gas, and store it in a protective atmosphere away from light for future use. A visual sensing array chip of the present invention has better sensitivity, accuracy and repeatability and can be widely used in the screening and prognosis monitoring of lung cancer diseases; the preparation method of a visual sensing array chip of the present invention, making Convenient, less time-consuming, greatly reducing costs.

Description

technical field [0001] The invention relates to a disease detection device, in particular to a visual sensing array chip and a preparation method thereof. Background technique [0002] Lung cancer is one of the most common malignant tumors, and its high morbidity and mortality seriously threaten human health. In view of the fact that lung cancer has no obvious symptoms in the early stage and is easily ignored by patients and doctors, most of the diagnosed patients are already in the middle and advanced stages and have a short survival time. Although traditional lung cancer diagnostic methods such as imaging detection, pathological detection, and microscopic examination have certain effects, they still have limitations such as invasiveness, high false negative / positive, and high cost. When the human body breeds lung cancer, cancer cells will produce certain marker substances, these chemical components are discharged into the blood, and then exchanged through the lungs, refle...

AI Technical Summary

Problems solved by technology

The doctoral dissertation "Research on Rapid Noninvasive Screening Method for Lung Cancer with Nano-gold-Porphyrin Composite Sensor Array Chip" discloses a 6×6 sensor array chip to realize the detection of symbolic organic volatiles in lung cancer breath and clinical breath samples Rapid identification and detection, but not all of the 36 sensitive materials have the ability to identify lung cancer breath markers and clinical samples, and the production time is long, the detection cost is high, and the detection efficiency is low

In addition, there are trace amounts of disease-related components in clinical lung cancer breath samples, and conventional detection methods cannot fully reflect the development of lung cancer.

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