A kind of preparation method of novel Alaska cod multifunctional peptide modified by taurine

A taurine and multi-functional technology, applied in the biological field, can solve problems such as environmental pollution and waste of resources, and achieve the effects of reducing production costs, facilitating body absorption, and convenient operation
CN109354600BActive Publication Date: 2021-08-10ZHEJIANG OCEAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG OCEAN UNIV
Publication Date
2021-08-10

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Abstract

The present invention provides a novel taurine-modified Alaska cod multifunctional peptide, which comprises: a natural polypeptide with an amino acid sequence of SEQ ID NO.1, and a substituent bound to the polypeptide and introduced for modification, The substituent is taurine; the preparation method of the polypeptide includes preparation of protective peptide fragments, microwave condensation reaction, and deamination protection reaction, wherein the steps of preparing the protective peptide fragments are: dissolving the natural polypeptide in sodium carbonate solution, adding amino-containing The acetone solution of the terminal protection group and the promoter is stirred and reacted, extracted and precipitated; the above-mentioned promoter includes anthranilic acid and isonicotinamide. The novel polypeptide provided by the invention has high activity, good stability, no helical structure, good fluidity and high swelling rate, and has biological activities such as anti-oxidation, scavenging free radicals, and promoting brain development; the reaction conversion rate and yield during preparation are high, The synthesis time is short, the yield of by-products is low, the product is easy to purify, and the production cost is low.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, and in particular relates to a preparation method of a novel multifunctional peptide of Alaska cod modified with taurine. Background technique

[0002] Cod, also known as cod, is one of the main edible fish. Cod is native to the cold waters of the North Atlantic from northern Europe to Canada and the eastern United States. At present, the main producing countries of cod are Canada, Iceland, Norway and Russia, and the main producing countries of Japan are Hokkaido. China is produced in the Yellow Sea and the northern part of the East China Sea. The main fishing grounds are in the northern part of the Yellow Sea, the east-southeast of Gaojiao in Shandong, the southern part of Haiyang Island and the southeast sea area. Cod is one of the fish with the largest annual catch in the world and has important economic value. Cod is an important economic fish for the production of surimi products, and its in...

Claims

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