Method for preparing spherical baricitinib crystal

A crystallization and spherical technology, applied in the direction of organic chemistry, organic chemistry, etc., can solve the problem of high viscosity of baricotine and achieve good fluidity
CN109384792AInactive Publication Date: 2019-02-26WEIHAI GUANBIAO INFORMATION TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WEIHAI GUANBIAO INFORMATION TECH
Publication Date
2019-02-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for preparing a spherical baricitinib crystal. The method for preparing the spherical baricitinib crystal comprises the following steps: adding baricitinib into water, heating to 40-50 DEG C, dissolving, and filtering; keeping the filtrate at a temperature range of 5-15 DEG C, adding 95% ethanol which is 0.2-0.3 time of the volume of filtrate obtained at the firststep while stirring, culturing a crystal for 1-2.5 hours at a constant temperature, and stirring; continuously stirring, cooling to subzero 5 to 0 DEG C, continuously culturing the crystal for 1.5-2hours at the constant temperature, and stirring; carrying out suction filtration, washing filtrate cakes, and drying at 50-60 DEG C. By adopting the technical scheme of the invention, the spherical baricitinib crystal is obtained, and the spherical baricitinib crystal has very good flowability and is free of adhesion in the pressing process.
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Description

technical field

[0001] The invention relates to a preparation method of spherical baricotide crystals, which belongs to the technical field of raw material medicine preparation. Background technique

[0002] Rheumatoid arthritis is a chronic, inflammatory synovitis-based systemic disease of unknown etiology. It is characterized by polyarticular, symmetrical, and aggressive arthritis of the small joints of the hands and feet, often accompanied by involvement of extra-articular organs and positive serum rheumatoid factor, which can lead to joint deformities and loss of function. According to statistics from relevant departments, the disability rate of rheumatoid arthritis in my country is as high as 70%.

[0003] According to reports, the incidence of rheumatoid arthritis in our country is 0.3%-0.4%. If these rheumatoid arthritis patients are not treated effectively, the final impact will be lifelong disability, seriously affecting the patient's life and quality of life. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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