Method for judging measuring result of platelet aggregation rate and calibration method of platelet aggregator

Abstract

The invention provides a method for judging the measuring result of the platelet aggregation rate. The method comprises the following steps: a normal whole blood sample is selected, the anaemic platelet plasma transmittance PPP0 and the blood-rich platelet plasma transmittance PRP0 are measured, and the transmittance difference P0 of the whole blood sample is calculated, wherein P0=PPP0-PRP0; a measured whole blood sample is selected, the anaemic platelet plasma transmittance PPP and the blood-rich platelet plasma transmittance PRP are measured, and the transmittance difference P of the measured sample is calculated, wherein P=PPP-PRP; the platelet separation degree index DI of the measured sample is calculated, wherein DI=P / P0=(PPP-PRP) / (PPP0-PRP0); the platelet aggregation rate of blood-rich platelet plasma is measured through a platelet aggregator; and whether the measured platelet aggregation rate is reliable or not is judged according to the platelet separation degree index DI ofthe measured sample. According to the method for judging the measuring result of the platelet aggregation rate, by referring to the platelet separation degree index of the measured sample, the measuring result of the platelet aggregation rate of the measured sample is judged reliably.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for judging a platelet aggregation rate measurement result and a calibration method suitable for a platelet aggregation meter. Background technique [0002] Optical turbidimetry is a more practical and easy-to-promote clinical method for detecting platelet aggregation. This method is simple to operate, inexpensive, and well correlated with clinical events. It is the gold standard for detecting platelet aggregation. [0003] Platelet-rich plasma (PRP) is a suspension of platelets in plasma. The platelets are evenly dispersed, and the turbidity is proportional to the number of platelets contained in the plasma. When the platelet aggregation inducer is added, the inducer and platelet The above receptors bind, the platelets are activated, and the platelets deform to further release endogenous substances, resulting in aggregation and increased light transmittance. The higher...

AI Technical Summary

Problems solved by technology

[0005] The platelet aggregation rate measured by the existing method is stable when the platelet concentration in the blood sample reaches a certain level, but if the platelet concentration is less than a certain value, the aggregation rate will also decrease, making the instrument report The aggregation rate is unreliable and cannot accurately reflect the platelet aggregation function. At present, before performing the platelet aggregation function test, hospitals generally use a hematology analyzer to count the platelets first, so as to measure the platelet concentration. If the measured value is higher than a certain When the value is higher, the platelet aggregation rate result obtained from the measurement is a reliable value, otherwise, it will report a doubtful result

This method is cumbersome to operate, and requires the use of extra blood analyzers and other instruments, and it is impossible to obtain the results at one time when measuring the platelet aggregation rate.

Images