Application of rat tail collagen in field of cosmetics

A technology for rat tail collagen and cosmetics, which is applied to cosmetics, cosmetic preparations, cosmetic preparations and other directions, can solve problems such as affecting the quality of cosmetics, and achieve the effects of controllable source quality, simple extraction and separation process, and inhibition of melanin synthesis.

Inactive Publication Date: 2019-03-08
GUANGDONG ZHONGERJIAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Therefore, an application of rat tail collagen in the field of cosmetics has been developed, which is used to solve the problem in the prior art that cosmetics containing collagen usually need to add toners, flavoring agents, stabilizers and preservatives, which seriously affect the quality of cosmetics. The technical defect has become a problem to be solved urgently by those skilled in the art

Method used

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  • Application of rat tail collagen in field of cosmetics
  • Application of rat tail collagen in field of cosmetics
  • Application of rat tail collagen in field of cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] This example is a specific example of extracting rat tail collagen from rats.

[0027] The extraction method of rat tail collagen comprises the following steps:

[0028] (1) SPF grade rats were taken, and after euthanasia, the tails were cut off immediately, placed on ice, peeled off the skin, flattened, bones and muscles removed, and placed in 0.01 to 0.2 mol / L Tris~HCl buffered saline solution, the extracted tail collagen is white filamentous.

[0029] (2) The above-mentioned filaments are pretreated at 0-10° C. for 4-36 hours, stirred to remove impurities, filtered to dry water, and added with 0.05-2 mol / L acetic acid solution. Add pepsin at a ratio of 1; 1000 to 1; 50000, add in three times, and finish adding in 12 to 36 hours. During this period, stir continuously until all the tail tendons are enzymatically hydrolyzed and present as latex. Enzymolysis lasts for 36-144 hours.

[0030] (3) Centrifuge the latex-like solution at 0-10°C for 10-40 minutes to remove...

Embodiment 2

[0036] This example is a specific example of extracting rat tail collagen from mice.

[0037] The extraction method of rat tail collagen comprises the following steps:

[0038] (1) Take SPF mice, and after euthanasia, immediately cut off the tail, put it on ice, peel off the skin, flatten it, remove the bone and muscle, and place it in a 0.01-0.2mol / L Tris~HCl buffered saline solution, the extracted tail collagen is white filamentous.

[0039] (2) The above-mentioned filaments are pretreated at 0-10° C. for 4-36 hours, stirred to remove impurities, filtered to dry water, and added with 0.05-2 mol / L acetic acid solution. Add pepsin at a ratio of 1; 1000 to 1; 50000, add in three times, and finish adding in 12 to 36 hours. During this period, stir continuously until all the tail tendons are enzymatically hydrolyzed and present as latex. Enzymolysis lasts for 36-144 hours.

[0040](3) Centrifuge the latex-like solution at 0-10°C for 10-40 minutes to remove solidified matter ...

Embodiment 3

[0046] This example is a specific example of using the rat tail collagen stock solution prepared in Example 1 to prepare a facial mask.

[0047] Table 1: Mask Prescription

[0048]

[0049] The preparation method is as follows:

[0050] (1) Add an appropriate amount of water to dissolve the rat tail collagen in phase A until completely dissolved, and set aside.

[0051] (2) Dissolve sodium hyaluronate, coenzyme Q10, serum albumin, and 1,3-butanediol in phase B in an appropriate amount of water, heat to dissolve completely, and wait for cooling before use.

[0052] (3) Add the product in step (1) dropwise to the solution of (2) under ice bath conditions, and stir for half an hour to make it fully combined.

[0053] (4) Add castor oil and glycerin in phase C to an appropriate amount of water to dissolve.

[0054] (5) Keep the ice bath at a low temperature, drop the solution of (3) into (4), and stir rapidly to disperse.

[0055] (6) Add all the remaining amount of water i...

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Abstract

The invention belongs to the field of cosmetics research and development, and particularly relates to application of rat tail collagen in the field of cosmetics. Compared with conventional collagen onthe market, in addition to the characteristics of general collagen, the rat tail collagen has the advantages of stable triple helix structure, high collagen activity and low immunogenicity; the source quality is controllable, the biosafety is high, and the reduction of biological activity by radiation sterilization is not needed; through experimental determination, the rat tail collagen preparedaccording to the technical scheme has the performance of whitening, melanin synthesis inhibition, anti-oxidation, anti-allergy, hormone skin repair and acne removal. The application of the rat tail collagen in the field of cosmetics overcomes the technical defect that the quality of the cosmetics is seriously affected due to addition of toners, flavoring agents, stabilizers and preservatives intocollagen-containing cosmetics in the prior art.

Description

[0001] This application is required to be submitted to the Chinese Patent Office on March 16, 2018. The application number is 201810218080.6. The title of the invention is "A Application of Collagen in the Field of Cosmetics". The applicant is "Guangdong Zhongerjian Biotechnology Co., Ltd.". priority, the entire contents of which are incorporated in this application by reference. technical field [0002] The invention belongs to the field of cosmetic research and development, and in particular relates to the application of rat tail collagen in the field of cosmetics. Background technique [0003] With the rapid development of the economy, modern people, especially modern women, have higher and higher pursuit of beauty. Among them, due to the wide range of sources of collagen and the absence of chemically synthesized reagents, collagen has developed rapidly in the field of beauty and cosmetic applications. It is a new raw material for high-quality cosmetics and an ideal fille...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/65A61Q19/02A61Q19/00A61P17/10
CPCA61K8/65A61K2800/10A61Q19/005A61Q19/008A61Q19/02A61P17/10A61Q19/00A61Q19/08A61Q19/007
Inventor 唐小江卢肖宇胡伟肖凌琥任海涛路露
Owner GUANGDONG ZHONGERJIAN BIOTECH CO LTD
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