Plugging device and preparation method thereof

A technology of occluder and occlusion disk, which is applied in medical science, surgery, etc., can solve the problems of thrombus shedding, easy formation of thrombus, thromboembolism, etc., and achieve the effect of promoting endothelialization and avoiding thrombus formation

Active Publication Date: 2019-03-15
LIFETECH SCIENTIFIC (SHENZHEN) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the use of the occluder, when the heart defect occluder comes into contact with blood, thrombus is easily formed on the surface of the occluder, and the formed thrombus may fall off the device, causing problems such as thromboembolism

Method used

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  • Plugging device and preparation method thereof
  • Plugging device and preparation method thereof
  • Plugging device and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0064] The preparation method of the occluder of an embodiment, comprises the steps:

[0065] Step 110: Providing a support net.

[0066] The support net can be formed by weaving braided wires or by pipe cutting or injection molding.

[0067] It should be noted that after the support net is formed, the following step 120 can be performed after the support net is further shaped. Further, if the occluder also includes a flow-blocking film, the flow-blocking film may also be fixed in the support net before performing the following step 120 .

[0068] Step 120: forming an anti-thrombotic film on the support net by leaching and / or spraying, wherein the anti-thrombotic film includes an endothelialization-promoting film; the endothelialization-promoting film contains a degradable polymer and is dispersed in the degradable polymer The endothelialization-promoting substance; or the endothelialization-promoting membrane contains the endothelialization-promoting substance, and the anti...

Embodiment 1

[0081] A support net formed by weaving nickel-titanium alloy wire is provided, and the support net is shaped to form a structure including two occlusion discs and a waist with large ends and a small middle.

[0082] Dissolve racemic polylactic acid in ethyl acetate to prepare saturated racemic polylactic acid solution; dissolve phosphatidylcholine in ethanol to prepare saturated phosphatidylcholine solution; racemic polylactic acid The solution and the phosphatidylcholine solution are mixed at a volume ratio of 9:1 to obtain a mixed solution. Wherein, the weight average molecular weight of the racemic polylactic acid is 30w.

[0083] Completely immerse the shaped supporting net in the above mixed solution, collect it after 10 seconds, and form an antithrombotic film on the surface of the supporting net after the solvent volatilizes to obtain an occluder. Wherein, the antithrombotic membrane is a continuous membrane, and the antithrombotic membrane covers the entire surface of...

Embodiment 2

[0086] Provide a support net formed by weaving polydioxanone braided wire, and shape the support net to form a structure with two large ends and a small middle, including two occluded discs and a waist, respectively. A polydioxanone-blocking film was sutured on one waist.

[0087] Dissolve racemic polylactic acid in ethyl acetate to prepare a racemic polylactic acid solution with a concentration of 10 mg / mL; dissolve phosphatidylcholine in ethanol to prepare a phosphatidylcholine with a concentration of 20 mg / mL solution; the racemic polylactic acid solution and the phosphatidylcholine solution are mixed at a volume ratio of 9:1 to obtain a mixed solution. Among them, the weight average molecular weight of the racemic polylactic acid is 1000.

[0088] Completely immerse a plugging disc of the above-mentioned support net in the above-mentioned mixed solution, take it out after 10 seconds, blow off the solvent retained on the support net with cold wind, and form an antithrombot...

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Abstract

The invention relates to a plugging device and a preparation method thereof. The plugging device comprises a supporting net. The surface of the supporting net is coated with an anti-thrombus membrane,and the anti-thrombus membrane comprises an endothelialization promoting membrane. The endothelialization prompting membrane comprises a degradable polymer and endothelialization promoting matter dispersed in the degradable polymer. Or the endothelialization prompting membrane comprises the endothelialization promoting matter. The anti-thrombus membrane further comprises a controlled release membrane covering the endothelialization promoting membrane. The controlled release membrane comprises the degradable polymer. By means of the plugging device, thrombosis can be reduced or avoided.

Description

technical field [0001] The invention relates to the field of interventional medical devices, in particular to an occluder and a preparation method thereof. Background technique [0002] Percutaneous interventional technology is a disease treatment method that has developed very rapidly in recent years, and the applicable fields of this technology are becoming more and more extensive. Among them, catheter interventional therapy can deliver various devices and drugs to the heart, arteriovenous blood vessels and other parts of the human body. Wherein, the device may be an occluder, a blood vessel plug, a blood vessel filter, and the like. [0003] Among them, the occluder can be used for minimally invasive treatment of congenital heart diseases such as atrial septal defect, ventricular septal defect, patent ductus arteriosus and patent foramen ovale. However, during the use of the occluder, when the heart defect occluder comes into contact with blood, thrombus is easily forme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/00
CPCA61B17/0057A61B2017/00831A61B2017/00004A61B2017/00654A61B2017/00606A61B2017/00601A61B2017/00597
Inventor 褚华磊
Owner LIFETECH SCIENTIFIC (SHENZHEN) CO LTD
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