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Microneedle array assembly, drug delivery device and method for administering liquid across a broad area at low pressure

A microneedle array and delivery device technology, applied in drug delivery, drug devices, microneedles, etc.

Active Publication Date: 2019-03-15
SORRENTO THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are disturbing factors associated with the flow through the microneedle array such that the flow may be associated with too few microneedles of the microneedle array

Method used

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  • Microneedle array assembly, drug delivery device and method for administering liquid across a broad area at low pressure
  • Microneedle array assembly, drug delivery device and method for administering liquid across a broad area at low pressure
  • Microneedle array assembly, drug delivery device and method for administering liquid across a broad area at low pressure

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Embodiment Construction

[0014] Exemplary embodiments are described below and illustrated in the drawings, wherein like reference numerals refer to like parts throughout the several views. The described embodiments provide examples and should not be construed as limiting the scope of the invention. Other embodiments, as well as modifications and improvements of the described embodiments will occur to those skilled in the art, and all such other embodiments, modifications and improvements are within the scope of the invention.

[0015] In the following, a very brief and general initial discussion of the drug delivery device 10 of the first embodiment is followed by a more detailed discussion, for example of some of the individual subcomponents of the device 10 . A discussion directed primarily to the structural features of the apparatus 10 is followed by a discussion more specifically related to the methods herein.

[0016] refer to figure 1 , device 10 is shown in a partially activated configuration...

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Abstract

A uniformity control membrane can be securely engaged against an upstream side of a microneedle array and configured so that resistance to flow through the uniformity control membrane is substantiallygreater than the resistance to flow through the microneedle array. These differences in flow resistance can facilitate uniform administration of a liquid formulation into the patient's skin across abroad area and at a relatively low pressure, such as by way of capillary action. The administration of the liquid formulation into the patient's skin across the broad area can result from the liquid formulation being administered by way of at least a majority of the microneedles of the microneedle array.

Description

technical field [0001] The present invention generally relates to devices for delivering liquid formulations into the skin of a patient. In particular, this document relates to devices having microneedle arrays for transdermal delivery of liquid formulations. Background technique [0002] A number of devices utilizing microneedle arrays have been previously developed for the transdermal delivery of fluid drugs and other pharmaceutical compounds. For example, microneedles have the advantage of causing less pain to the patient than larger conventional needles. Furthermore, the traditional way of delivering fluid drugs subcutaneously (and often intramuscularly) via traditional needles delivers large volumes of fluid drug simultaneously, often producing peaks in drug bioavailability. For drugs with certain metabolic profiles, this is not a significant issue. However, many drugs benefit from steady-state concentrations in the patient's blood; a well-known example of such a dru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61K9/00
CPCA61M37/0015A61M2037/0023A61M2037/0061A61M2037/0038A61M2037/0007
Inventor A·T·贝克R·F·罗斯E·D·加斯比L·哈根
Owner SORRENTO THERAPEUTICS INC