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Method for detecting fingerprints of Radix Paeoniae Alba
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A fingerprint and detection method technology, applied in the field of traditional Chinese medicine detection, can solve the problems of not being able to objectively and truly reflect the quality of Radix Paeoniae Alba, and achieve the effect of ensuring clinical curative effect
Active Publication Date: 2021-05-25
NANJING HAICHANG CHINESE MEDICINE GRPCO LTD +1
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Problems solved by technology
At present, the content of Radix Paeoniae Alba is only determined for a single or a few active ingredients, which cannot objectively and truly reflect the quality of Radix Paeoniae Alba
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Embodiment 1
[0044] Example 1 Establishment and application of Radix Paeoniae Alba control fingerprint
[0047] Ethanol, phosphoric acid (analytical grade, Nanjing Weizhicheng Chemical Reagent Co., Ltd.), acetonitrile (chromatographic grade, American Tiandi Company), water (Hangzhou Wahaha Company);
[0048] 10 different batches of Radix Paeoniae Alba were purchased from Anhui Suntech Chinese Medicine Co., Ltd., batch number 170901, raw Radix Paeoniae Alba (common goods); Tongling Hetian Traditional Chinese Medicine Co., Ltd., batch number 20161024 raw Radix...
Embodiment 2
[0064] Embodiment 2 methodological investigation
[0065] 1. Precision test
[0066] Get the same part of Radix Paeoniae Alba, prepare the test solution according to the step (1) method of the above-mentioned embodiment 1, repeat the sample injection 6 times according to the chromatographic conditions of the above-mentioned embodiment 1 step (3), take paeoniflorin as the reference peak, calculate The relative retention time of each common peak of the 6 chromatographic peaks and the RSD of the relative peak area are all less than 1.3%. The National Pharmacopoeia Commission "Similarity Evaluation Software (2004A)" is used to evaluate the similarity. The similarity is 0.99, indicating that the precision of the instrument is good.
[0067] 2. Repetitive experiment
[0068] Accurately weigh 6 parts of the decoction pieces powder 0.5g of the same batch of Radix Paeoniae Alba, the step (1) method of above-mentioned embodiment 1 makes 6 parts of need testing solution in parallel, pre...
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Abstract
The invention discloses a fingerprint detection method of Radix Paeoniae Alba. The method comprises the following steps: step 1, preparation of Radix Paeoniae Alba for test solution; step 2, preparation of mixed reference solution; step 3, precise absorption of test solution respectively Inject the high-performance liquid chromatograph with the mixed reference substance solution, and record the chromatogram; step 4, export the Radix Paeoniae Alba fingerprint instrument obtained in step 3, and import it into the Chinese medicine chromatographic fingerprint similarity evaluation system, and select different batches of Radix Paeoniae Alba The chromatographic peaks that all exist in the chromatogram are taken as common peaks; the control fingerprint of Radix Paeoniae Alba is generated by the average value calculation method; the relative retention time and relative peak area of each common peak are calculated. The method for detecting the fingerprint of Radix Paeoniae Alba provided by the invention has good stability, high precision and good reproducibility, and can comprehensively and objectively characterize the quality of Radix Paeoniae Alba.
Description
technical field [0001] The invention belongs to the technical field of traditional Chinese medicine detection, and in particular relates to a fingerprint detection method of Radix Paeoniae Alba. Background technique [0002] Radix Paeoniae Alba (Paeonia lactiflora Pall.) nourishes blood and restrains yin, softens liver and relieves pain, calms liver yang. Suppressing liver and relieving pain, nourishing blood and regulating menstruation, astringing yin and stopping sweating. Used for headache, dizziness, hypochondriac pain, abdominal pain, limb spasm, blood deficiency and chlorosis, irregular menstruation, spontaneous sweating, and night sweating. Radix Paeoniae Alba contains paeoniflorin, paeonol, paeoniflorin, benzoic acid, volatile oil, fatty oil, resin, tannin, sugar, starch, mucus, protein, β-sitosterol and triterpenes. Another Sichuan product contains an acidic substance that can inhibit Staphylococcus aureus. Flowers contain astragaloside, kaempferol 3,7-diglucosid...
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