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Identification of Potassium Manganese Ferricyanide and Determination of Manganese Content

A technology of potassium manganese cyanide and content, applied in the field of analysis and detection, can solve the problems of weak signal in vivo, complicated preparation of gadolinium agent, lack of targeting, etc., and achieve the effect of simple method, low detection cost and simple instrument

Active Publication Date: 2021-02-02
CHANGZHOU INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Currently, the main MRI contrast agent used in clinical practice is Gd. 3+ The complex is also the first paramagnetic contrast agent used in human magnetic resonance examination, but gadolinium has problems such as complicated preparation, lack of targeting, and weak signal in vivo, and may also cause a rare but extremely serious A new disease called nephrogenic systemic fibrosis

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  • Identification of Potassium Manganese Ferricyanide and Determination of Manganese Content

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: the qualitative identification of manganese potassium ferricyanide

[0040] ① Take a certain amount of manganese potassium ferricyanide solid to measure its 0° angle diffuse reflection signal, and there are strong absorption peaks at 377nm and 458nm.

[0041] ② Measure the 0° angle diffuse reflection signal of potassium ferricyanide solid, and an absorption peak appears at 650nm.

[0042] ③ if figure 1 As shown, compare the diffuse reflection signals of manganese potassium ferricyanide and potassium ferricyanide solid for qualitative identification of manganese potassium ferricyanide.

Embodiment 2

[0043] Embodiment 2: Quantitative Identification of Manganese Potassium Ferricyanide

[0044] ① Weigh 50.0 mg of potassium manganese ferricyanide solid powder, add 25.0 mL of 10% sodium hydroxide solution and stir for one hour, then add 3.0 ml of sulfuric acid and stir for half an hour to dissolve potassium manganese ferricyanide, add water to set Dissolve it in a 100.0mL volumetric flask and prepare a solution with a certain concentration.

[0045] ② Prepare standard solutions of potassium ferricyanide and potassium permanganate with different concentrations.

[0046] ③Take an appropriate amount of potassium manganese ferricyanide solution, scan it within the range of 250-500nm with a UV spectrophotometer, select the absorption value of the absorption peak at 302nm, and use the potassium ferricyanide standard curve method to measure ferricyanide in the potassium manganese ferricyanide solution concentration of acid radicals. Under optimized experimental conditions, the line...

Embodiment 3

[0049] Embodiment 3: Quantitative Identification of Manganese Potassium Ferricyanide

[0050] ①Weigh 50.0mg of potassium manganese ferricyanide solid powder and mix it with a certain amount of potassium ferrocyanide, add 25.0mL of 10% sodium hydroxide solution and stir for one hour, then add 3.0ml of sulfuric acid and stir for half an hour, Dissolve the solid, add water to a volumetric flask of 100.0mL, and prepare a solution with a certain concentration.

[0051] ② Add a certain amount of ferric chloride solution to the solution to form a dark blue precipitate and separate the solid and liquid to obtain a solution for removing ferrocyanide ions.

[0052] 3. same as 2. in embodiment 2.

[0053] 4. get step 2. gained solution, follow-up operation step is with 3. in example 2, and the concentration of ferricyanide ion in the sample measured by experiment is 2.2 * 10 -4 mol / L.

[0054] 5. get the 2. gained solution of step, follow-up operation step is with 4. in the example 2,...

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Abstract

The invention belongs to the technical field of analysis and detection, and discloses a method for identifying potassium manganese ferricyanide and the determination of manganese content. The identification method includes: the first step: using solid diffuse reflectance to measure the characteristic absorption peak as a qualitative identification; the second step: using spectrophotometry to measure the content of ferricyanide in manganese potassium ferricyanide; the third step: using spectrophotometry Determination of the content of manganese after manganese potassium ferricyanide is oxidized by photometry; the fourth step: according to the ratio of ferricyanide to manganese, the composition of manganese potassium ferricyanide and the valence state of manganese can be deduced as quantitative identification. This method has the characteristics of stability, rapidity, convenience and simplicity.

Description

technical field [0001] The invention belongs to the technical field of analysis and detection, in particular to the identification of a paramagnetic contrast agent manganese potassium ferricyanide and the determination of manganese content, and in particular to the application of photometry. Background technique [0002] With the widespread clinical application of magnetic resonance imaging (MRI), because of its high tissue resolution and the ability to form images with different signal contrasts, it has now become an important tool for diagnosis; and magnetic resonance contrast agents have been developed It has become a reagent for further enhancing image contrast and improving diagnostic accuracy, and has been widely used in clinic as an important supplement of magnetic resonance imaging. [0003] Currently, the main MRI contrast agent used in clinical practice is Gd. 3+ The complex is also the first paramagnetic contrast agent used in human magnetic resonance examination...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/33
CPCG01N21/33
Inventor 壮亚峰吴学文陈建欣王丽
Owner CHANGZHOU INST OF TECH