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Universal polypeptide vaccine and application thereof in preparing drugs for treating/preventing pancreatic cancers

A peptide vaccine and a universal technology, applied in the field of universal peptide vaccines, can solve the problems of lack of preventive measures for pancreatic cancer and achieve the effect of reducing medical costs

Active Publication Date: 2019-04-02
HANGZHOU NEOANTIGEN THERAPEUTICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there are no effective preventive measures against pancreatic cancer

Method used

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  • Universal polypeptide vaccine and application thereof in preparing drugs for treating/preventing pancreatic cancers
  • Universal polypeptide vaccine and application thereof in preparing drugs for treating/preventing pancreatic cancers
  • Universal polypeptide vaccine and application thereof in preparing drugs for treating/preventing pancreatic cancers

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Embodiment 1

[0068] A universal peptide vaccine targeting the following six mutations: KRAS-G12R; KRAS-G12V; CDKN2A-H83Y; KRAS-Q61H; TP53-R248W; CDKN2A-P94L. The polypeptide sequences for the 6 mutations are specifically as described in Table 1.

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PUM

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Abstract

The present invention discloses a universal polypeptide vaccine. The universal polypeptide vaccine comprises at least one of the following 6 mutations: KRAS-G12R, KRAS-G12V, CDKN2A-H83Y, KRAS-Q61H, TP53-R248W and CDKN2A-P94L. Specifically, the universal polypeptide vaccine comprises at least one of the 6 mutations. The universal polypeptide vaccine can be used for preparing drugs for treating / preventing cancers (pancreatic cancers). The universal polypeptide vaccine has relatively good immunotherapeutic effects on the pancreatic cancers.

Description

technical field [0001] The invention relates to a universal polypeptide vaccine suitable for the treatment and prevention of pancreatic cancer. Background technique [0002] Pancreatic cancer (PAAD) is a highly malignant tumor of the digestive tract that is difficult to diagnose and treat. Its morbidity and mortality have increased significantly in recent years, and it is one of the malignant tumors with the worst prognosis. According to the latest statistics from the National Cancer Society in 2017, there were 53,670 new cases of pancreatic cancer in the United States, and 43,090 deaths. Compared with other malignant tumors, pancreatic cancer is the type of cancer with the closest new cases and death cases, which indirectly indicates the refractory nature of pancreatic cancer. On the other hand, the statistical report clearly pointed out that with the general improvement of tumor diagnosis and treatment in recent years, the survival rate of most malignant tumors has shown...

Claims

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Application Information

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IPC IPC(8): A61K39/00A61P35/00
CPCA61P35/00A61K39/0011Y02A50/30
Inventor 莫凡周秀卿林志伟陈荣昌马治明刘慧敏陈枢青
Owner HANGZHOU NEOANTIGEN THERAPEUTICS CO LTD
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