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Application of JQ1 or derivative of JQ1 in preparation of analgesic drugs

A technology of derivatives and drugs, applied in the field of medicine, can solve problems such as applications that have not been reported

Inactive Publication Date: 2019-04-05
NANHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no report about the application of BRD4 inhibitor JQ1 in analgesia

Method used

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  • Application of JQ1 or derivative of JQ1 in preparation of analgesic drugs
  • Application of JQ1 or derivative of JQ1 in preparation of analgesic drugs
  • Application of JQ1 or derivative of JQ1 in preparation of analgesic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] This example investigates the effect of BRD4 inhibitor JQ1 on formalin-induced inflammatory pain in mice.

[0026] The specific test is as follows:

[0027] Animal grouping and treatment: 50 male ICR mice, 8 weeks old, were divided into 3 groups according to the random number table method: vehicle control group (Control, n=7), formalin-induced inflammatory pain group (FM, n =10), different doses of JQ1 treatment groups (FM+12.5 mg / kg JQ1, n=10; FM+25 mg / kg JQ1, n=10; FM+50 mg / kg JQ1, n=10). Vehicle control group (Control): mice were intraperitoneally injected with vehicle DMSO (0.15 mL), and 1 hour later, 25 μL NS was injected into the right foot; FM group: mice were injected with vehicle DMSO (0.15 mL) 1 hour later, and then injected with 25 μL of 1% formalin solution; 1 hour after the intraperitoneal injection of JQ1 in the FM + different doses of JQ1 group, 25 μL of 1% formalin solution was injected into the sole of the right foot.

[0028] Pain behavior score: Aft...

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Abstract

The invention relates to the technical field of medicines, in particular to application of JQ1 or a derivative of the JQ1 in preparation of analgesic drugs. A test result shows that the BRD4 (bromodomain-containing protein 4) inhibitor JQ1 can effectively relieve acute inflammatory pain induced by formalin, and the expression lies in that the duration time of the pain response of mice is obviouslyshortened after JQ1 pretreatment. Experiments prove that the bromodomain-containing protein 4 inhibitor JQ1 has an obvious analgesic effect and can be used for preparation of the analgesic drugs.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of JQ1 or its derivatives in the preparation of analgesic drugs. Background technique [0002] As the fifth vital sign of human beings, pain is also one of the common clinical symptoms, which seriously affects people's quality of life and directly increases the burden on families and society. Inflammatory pain is a common type of pain, and the inflammatory response is involved in the generation and maintenance of pain. Inflammatory response is a warning signal and a defense response for the body to protect itself. The persistence of inflammatory response can lead to long-term chronic pain, seriously reduce the quality of life of patients and even cause huge economic and social problems. At present, the anti-inflammatory and analgesic drugs are mainly non-steroidal anti-inflammatory drugs, which exert anti-inflammatory and analgesic effects by inhibiting cyclooxy...

Claims

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Application Information

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IPC IPC(8): A61K31/551A61P29/00
CPCA61K31/551A61P29/00
Inventor 万炜徐杨曹文宇何洁周鑫钟小林陈熙刘政海曾佳玉王贞牛磊罗丹罗诗诗
Owner NANHUA UNIV
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