Traditional Chinese medicine composition for treating acute coronary syndrome and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating an acute coronary syndrome and a preparation method thereof and belongs to the technical field of treatment of the acutecoronary syndrome. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20 to 50 parts of honeysuckle flower, 20 to 50 parts of herba rhodiolae, 5 to 20 parts of leech, 10 to 50 parts of fructus trichosanthis, 10 to 30 parts of radix scrophulariae, 20 to 40 parts of radix angelica sinensis, 10 to 30 parts of rhizoma nardostachyos, 20 to 40 parts of radix salviae miltiorrhizae and 5 to 10 parts of liquorice root. The traditional Chinese medicine composition is mainly used for treating unstable angina pectoris of coronary artery disease, non-ST segment elevated myocardial infarction, the treatment of the coronary artery disease after blood reconstruction and assisting the treatment of ST segment elevated myocardial infarction; a pharmacodynamic research before clinical use proves that the traditional Chinese medicine composition can be used for alleviating a myocardial ischemia state of an expeirmental myocardial ischemia rat modeland has an oxidative stress resisting effect; the traditional Chinese medicine composition can be used for improving indexes of a myocardial enzyme and a myocardial injury marker, can be used for improving a vascular endothelial function and has the effects of resisting inflammation, stabilizing plaques and the like.

Description

technical field

[0001] The invention relates to the technical field of acute coronary syndrome treatment, in particular to a traditional Chinese medicine composition for treating acute coronary syndrome and a preparation method thereof. Background technique

[0002] Acute Coronary Syndrome (ACS) is a group of clinical syndromes based on the rupture or invasion of coronary atherosclerotic plaque followed by complete or incomplete occlusive thrombosis, including acute ST-segment elevation myocardial infarction. , acute non-ST segment elevation myocardial infarction and unstable angina (UA).

[0003] ACS is a common serious cardiovascular disease and a serious type of coronary heart disease. Common in the elderly, men and postmenopausal women, smoking, hypertension, diabetes, hyperlipidemia, abdominal obesity and patients with a family history of premature coronary heart disease. ACS patients often present with episodic chest pain, chest tightness and other symptoms, which ca...

Examples

preparation example Construction

[0045] The present invention provides the preparation method of the traditional Chinese medicine composition described in the above scheme, comprising the following steps:

[0046] 1) mixing Danshen with aqueous ethanol solution, performing reflux extraction, filtering, collecting the filtrate and concentrating to obtain the first thick paste, and collecting the filter residue as the first medicinal residue;

[0047] 2) honeysuckle, angelica and Gansong are mixed with water, carry out the first water extraction, collect and obtain volatile oil, extract and the second medicinal residue;

[0048] 3) The first medicinal residues described in step 1) and the second medicinal residues described in step 2) are mixed with Rhodiola rosea, melon, leech, Scrophulariaceae, licorice and water, and the second water extraction is carried out, filtered, concentrated and filtered. liquid to get paste;

[0049] 4) mixing the paste described in step 3) with the aqueous ethanol solution and lea...

Embodiment 1

[0072] Embodiment 1 A kind of traditional Chinese medicine granules for the treatment of acute coronary syndrome

[0073] 1. Pretreatment: Take 200g of honeysuckle, 200g of Rhodiola, 50g of leeches, 100g of Melon, 100g of Scrophulariaceae, 200g of Angelica, 100g of Gansong, 200g of Salvia and 50g of licorice, mix the herbs, rinse, bake Dry;

[0074] 2. Take the pretreated raw salvia miltiorrhiza, add 8 times the volume percentage of the salvia miltiorrhiza mass to 80% ethanol aqueous solution, extract by reflux extraction process, 60 ℃, extract 3 times, 1 hour each time, filter with 100-mesh filter membrane, and remove the residues For subsequent use; merge the filtrate to obtain an ethanol extract and the first medicinal residue;

[0075] 3. In step 2, the ethanol extract was concentrated under reduced pressure at 50°C (pressure 0.08Mpa) for 2h to obtain the first thick paste with a relative density of 1.10;

[0076] 4. Take the pretreated raw materials honeysuckle, angelic...

Embodiment 2

[0082] Embodiment 2 A kind of traditional Chinese medicine granules for the treatment of acute coronary syndrome

[0083] 1. Pretreatment: take honeysuckle 500g, rhodiola 500g, leech 200g, melon 500g, crocus 300g, angelica 400g, gansong 300g, salvia 400g and licorice 100g, pick out various herbs, rinse, drying;

[0084] 2. Take the pretreated raw material Salvia miltiorrhiza, add 9 times the mass of Salvia miltiorrhiza in volume percentage of 85% ethanol aqueous solution, extract by reflux extraction process, 80 ℃, extract 3 times, 2h each time, filter with 100 mesh membrane, and filter the residues For subsequent use; merge the filtrate to obtain an ethanol extract and the first medicinal residue;

[0085] 3. In step 2, the ethanol extract was concentrated under reduced pressure for 2h under the conditions of 50°C and a pressure of 0.09Mpa to obtain the first thick paste with a relative density of 1.15;

[0086] 4. Take the pretreated raw materials honeysuckle, angelica and...

technical field

[0001] The invention relates to the technical field of acute coronary syndrome treatment, in particular to a traditional Chinese medicine composition for treating acute coronary syndrome and a preparation method thereof. Background technique

[0002] Acute Coronary Syndrome (ACS) is a group of clinical syndromes based on the rupture or invasion of coronary atherosclerotic plaque followed by complete or incomplete occlusive thrombosis, including acute ST-segment elevation myocardial infarction. , acute non-ST segment elevation myocardial infarction and unstable angina (UA).

[0003] ACS is a common serious cardiovascular disease and a serious type of coronary heart disease. Common in the elderly, men and postmenopausal women, smoking, hypertension, diabetes, hyperlipidemia, abdominal obesity and patients with a family history of premature coronary heart disease. ACS patients often present with episodic chest pain, chest tightness and other symptoms, which ca...

Examples

preparation example Construction

[0045] The present invention provides the preparation method of the traditional Chinese medicine composition described in the above scheme, comprising the following steps:

[0046] 1) mixing Danshen with aqueous ethanol solution, performing reflux extraction, filtering, collecting the filtrate and concentrating to obtain the first thick paste, and collecting the filter residue as the first medicinal residue;

[0047] 2) honeysuckle, angelica and Gansong are mixed with water, carry out the first water extraction, collect and obtain volatile oil, extract and the second medicinal residue;

[0048] 3) The first medicinal residues described in step 1) and the second medicinal residues described in step 2) are mixed with Rhodiola rosea, melon, leech, Scrophulariaceae, licorice and water, and the second water extraction is carried out, filtered, concentrated and filtered. liquid to get paste;

[0049] 4) mixing the paste described in step 3) with the aqueous ethanol solution and lea...

Embodiment 1

[0072] Embodiment 1 A kind of traditional Chinese medicine granules for the treatment of acute coronary syndrome

[0073] 1. Pretreatment: Take 200g of honeysuckle, 200g of Rhodiola, 50g of leeches, 100g of Melon, 100g of Scrophulariaceae, 200g of Angelica, 100g of Gansong, 200g of Salvia and 50g of licorice, mix the herbs, rinse, bake Dry;

[0074] 2. Take the pretreated raw salvia miltiorrhiza, add 8 times the volume percentage of the salvia miltiorrhiza mass to 80% ethanol aqueous solution, extract by reflux extraction process, 60 ℃, extract 3 times, 1 hour each time, filter with 100-mesh filter membrane, and remove the residues For subsequent use; merge the filtrate to obtain an ethanol extract and the first medicinal residue;

[0075] 3. In step 2, the ethanol extract was concentrated under reduced pressure at 50°C (pressure 0.08Mpa) for 2h to obtain the first thick paste with a relative density of 1.10;

[0076] 4. Take the pretreated raw materials honeysuckle, angelic...

Embodiment 2

[0082] Embodiment 2 A kind of traditional Chinese medicine granules for the treatment of acute coronary syndrome

[0083] 1. Pretreatment: take honeysuckle 500g, rhodiola 500g, leech 200g, melon 500g, crocus 300g, angelica 400g, gansong 300g, salvia 400g and licorice 100g, pick out various herbs, rinse, drying;

[0084] 2. Take the pretreated raw material Salvia miltiorrhiza, add 9 times the mass of Salvia miltiorrhiza in volume percentage of 85% ethanol aqueous solution, extract by reflux extraction process, 80 ℃, extract 3 times, 2h each time, filter with 100 mesh membrane, and filter the residues For subsequent use; merge the filtrate to obtain an ethanol extract and the first medicinal residue;

[0085] 3. In step 2, the ethanol extract was concentrated under reduced pressure for 2h under the conditions of 50°C and a pressure of 0.09Mpa to obtain the first thick paste with a relative density of 1.15;

[0086] 4. Take the pretreated raw materials honeysuckle, angelica and...

Images