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A sulfonated polyetheretherketone-based bone repair composite material

A technology of sulfonated polyether ether ketone and composite materials, which is applied in organic chemistry, chemical instruments and methods, carrier binding/immobilizing peptides, etc., can solve the problems of single physiological function of the body and the inability to achieve the unity of multiple properties, and achieve Good biocompatibility, promotion of bone marrow mesenchymal stem cell adhesion, and high production efficiency

Active Publication Date: 2022-07-01
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These two modification methods provide a certain promotion for the application of polyetheretherketone (PEEK) in the field of tissue engineering scaffolds, but the simple surface chemical modification and coating modification have a single physiological effect on the body and cannot achieve multiple Unified performance

Method used

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  • A sulfonated polyetheretherketone-based bone repair composite material
  • A sulfonated polyetheretherketone-based bone repair composite material
  • A sulfonated polyetheretherketone-based bone repair composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] (1) Polish one side of a cylindrical polyetheretherketone (PEEK) with a diameter of 10mm and a thickness of 1mm to mirror smoothness, ultrasonically clean it with acetone, absolute ethanol and deionized water for 3 times for 15 minutes each time, and then at room temperature Dry for 24 hours to obtain a spare polyetheretherketone (PEEK); in a ventilated table, the polyetheretherketone (PEEK) was subjected to 18.4mol / L concentrated sulfuric acid rotary sulfonation for 40s, and then washed with ultrapure water to remove residual concentrated sulfuric acid and water. Thermal treatment to remove sulfur (hydrothermal conditions: 120°C, 4h), in N 2 The sulfonated polyether ether ketone (S-PEEK) was obtained after drying in airflow for 24 h.

[0050] (2) Weigh 33.62g EDTANa 2 (Ethylenediaminetetraacetic acid disodium salt), dissolve in 2000ml ultrapure water, stir to make 0.05M / L EDTANa 2 solution, add NaOH solid particles while stirring, after the solution is clarified, sto...

Embodiment 2

[0073] Same as Example 1, the difference is that the preparation process of step (1) sulfonated polyether ether ketone is omitted.

[0074] The results show that there is no 3D network structure on the surface of the material. Although the surface structure is polished by sandpaper, the surface is still rough and there are many scratches on the surface. It is generally believed that the 3D network structure is beneficial to the adhesion of cells due to its increased surface roughness and enhanced hydrophilicity. Sulfonated polyetheretherketone materials of nanoproteins.

Embodiment 3

[0076] Same as Example 1, the difference is that the hydrothermal treatment step in the preparation process of step (1) sulfonated polyether ether ketone is omitted.

[0077] The results showed that most of the SD rat bone marrow mesenchymal stem cells died without the ability of attachment, proliferation and differentiation.

[0078] The purpose of the hydrothermal treatment step is two: first: remove the residual concentrated sulfuric acid (because the presence of residual concentrated sulfuric acid is not conducive to cell attachment, proliferation and differentiation); second: the hydrothermal treatment can stabilize the sulfonated polyether ether The 3D network structure on the surface of the ketone can reduce the unfavorable effects on cell attachment, proliferation and differentiation caused by the instability of the 3D network structure in the later experiments.

[0079] If there is no hydrothermal treatment step, the residual sulfuric acid of the sulfonated polyethere...

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Abstract

The invention belongs to the medical field of biological tissue engineering, and more particularly relates to a sulfonated polyetheretherketone-based bone repair composite material. The sulfonated polyether ether ketone-based bone repair composite material uses the sulfonated polyether ether ketone as a carrier, and the surface is loaded with nano-proteins. The preparation method includes: washing, hydrothermalizing and drying polyether ether ketone after acid solution sulfonation treatment to obtain sulfonated polyether ether ketone; adding nano protein solution dropwise to the surface of sulfonated polyether ether ketone, then freeze-drying and freeze-drying and disinfection to obtain a sulfonated polyetheretherketone-based bone repair composite material. The product of the present invention has good biocompatibility. It has been verified by experiments that it can promote the adhesion, proliferation and differentiation of SD rat bone marrow mesenchymal stem cells. At the same time, it also has excellent properties such as anti-oxidative stress and antibacterial. The invention has the advantages of simple synthesis and preparation, simple process, high preparation efficiency, and can be mass-produced.

Description

technical field [0001] The invention belongs to the medical field of biological tissue engineering, and more particularly relates to a sulfonated polyetheretherketone-based bone repair composite material. Background technique [0002] Polyetheretherketone (PEEK) is a semi-crystalline polymer with a crystallinity typically between 30%. Polyetheretherketone (PEEK) has excellent properties such as non-toxicity, high melting temperature (Tm=340°C), high glass transition temperature (Tg=143°C), chemical resistance, and wear resistance. Polyetheretherketone (PEEK) was first introduced into the medical field in the early 1990s. It has many excellent properties. The elastic modulus of polyetheretherketone (PEEK) is between 3-4GPa, which is close to that of cortical bone (~ 18GPa), can have a good docking with human bone, so it can be used as human hard tissue implant material. Polyetheretherketone (PEEK) is well-formed and can be processed by conventional techniques including inje...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/00A61L27/18A61L27/34A61L27/54A61L27/56C07K17/08C07K1/34
CPCA61L27/18A61L27/34A61L27/54A61L27/56C07K17/08C07K1/34A61L2430/02A61L2300/252A61L2300/40C08L61/16C08L89/00
Inventor 李达闵永刚刘胜东刘屹东
Owner GUANGDONG UNIV OF TECH
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