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Application of morin and its derivatives in the preparation of anti-Zika virus drugs

A technology of Zika virus and morin, applied in antiviral agents, resistance to vector-borne diseases, pharmaceutical formulations, etc., to achieve the effect of inhibiting plaque effect and improving economic value

Active Publication Date: 2021-06-22
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Morin is a flavonoid compound extracted from the bark of Moraceae plants such as yellow mulberry and Morus orange tree and many Chinese herbal medicines. It has anti-oxidation, antibacterial, anti-atherosclerosis, anti-inflammatory immunity, Anti-tumor and other effects, but it has not been reported in anti-Zika virus drugs

Method used

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  • Application of morin and its derivatives in the preparation of anti-Zika virus drugs
  • Application of morin and its derivatives in the preparation of anti-Zika virus drugs
  • Application of morin and its derivatives in the preparation of anti-Zika virus drugs

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Embodiment Construction

[0033] Examples are further listed below to describe the present invention in detail. It should also be understood that the following examples are only used to further illustrate the present invention, and should not be construed as limiting the protection scope of the present invention. Some non-essential improvements and adjustments made by those skilled in the art according to the principles set forth in the present invention all belong to the present invention scope of protection. The specific process parameters and the like in the following examples are only examples of the appropriate range, that is, those skilled in the art can make a selection within the appropriate range through the description herein, and are not limited to the specific data exemplified below.

[0034] The cells used in the present invention are African green monkey kidney cells (Vero cells), which are cultured in DMEM medium containing 10% fetal bovine serum, 100U / L penicillin and streptomycin;

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Abstract

The invention discloses the application of morin and its derivatives in the preparation of anti-Zika virus medicines. It has been verified that morin has obvious anti-Zika virus activity, and can significantly inhibit the plaque effect, mRNA and protein expression levels and the activity of NS2B‑NS3 protease produced by Zika virus infection. 100% inhibition effect is achieved. Morin is less toxic to cells, and has no toxicity to Vero cells in the concentration range of 0-200 μM. IC of morin against Zika virus 50 It was 3.077±0.83 μM, and the safety index was greater than 66. The invention develops new uses of morin, improves the economic value of morin, and also provides a theoretical and practical basis for the application of morin in the preparation of anti-Zika virus drugs.

Description

technical field [0001] The present invention relates to the application of morin and its derivatives, in particular to the application of morin and its derivatives in the preparation of anti-Zika virus drugs. Background technique [0002] Zika virus is a mosquito-borne virus first discovered in monkeys in Uganda in 1947 and confirmed in humans in 1952. It has attracted widespread attention worldwide due to the outbreak in Brazil in 2015. As of March 2017, it has Host-transmitted Zika virus infection has been confirmed in at least 84 countries and territories. The group most affected by Zika virus is pregnant women, whose infection can cause abnormal brain development in the fetus, known as microcephaly. In addition, Zika virus infection can also cause neurological disorders, including Guillain-Barré syndrome, meningoencephalitis and myelitis, and may even cause testicular damage and eventually male sterility. Zika virus is mainly transmitted to humans through the Asian tig...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P31/14
CPCA61K31/352A61P31/14Y02A50/30
Inventor 邹敏柳红妙李琳李晓娟柯昌文杨海涛刘叔文
Owner SOUTHERN MEDICAL UNIVERSITY
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